Chemical Name：(1,3-Dioxo-4,5,6,7-tetrahydroisoindolin-2-yl)methyl 2,2-dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropane-1-carboxylate
CAS：7696-12-0

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Not classified	-	-	-	-	Although LD50 value 4,600 mg/kg of the oral administration test employing a rat (EHC 98 (1990)), which corresponded to the U.N. GHS acute toxicity Category 5, it fell under unadopted category in Japan and was classified into "Not classified".
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	Since LD50 value of the dermal administration test employing rats was >5,000 mg/kg (EHC 98 (1990)) , it was classified into "Not classified".
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	Classification not possible due to lack of data
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	This substance is a solid whose saturated vapor pressure level (30degC)is 1.26*10^-5 mg/L. Since LC50 value of 3-hour inhalation exposure test employing rats is >2.74 mg/L (HSDB (2001)), the dust standard is applied. Since 4-hour equivalent LC50 value is >2.06 mg/L, classification cannot be specified, and classification is not possible.
2	Skin corrosion/irritation	Classification not possible	-	-	-	-	Classification is not possible since the exposures time is unknown despite a description of "no irritation" in the results of either case of two skin irritation tests with rabbits (EHC 98 (1990)).
3	Serious eye damage/eye irritation	Category 2B	-	Warning	H320: Causes eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling.	There are descriptions of "slight" and "It is a transient condition and recovered after 48 hours," respectively, about the two determinations of the eye irritation test employing rabbits. (EHC 98 (1990)). As mentioned above, it was classified into Category 2B.
4	Respiratory sensitization	Classification not possible	-	-	-	-	Classification is not possible since there is no data.
4	Skin sensitization	Classification not possible	-	-	-	-	For humans, it has been described that "there is no sensitizing properties" in the half-sealing patch test employing a 1% solution in 200 healthy persons (EHC 98 (1990)). For animals, although it has been described that "racemic mixture and 1R, cis/Tran isomer were not acknowledged to be the sensitization substances in guinea pig" (EHC 98(J), (1990)), the details, such as dosage, have not been described. As mentioned above, classification is not possible due to insufficient data.
5	Germ cell mutagenicity	Not classified	-	-	-	-	From the description of the body cell in vivo mutagenicity test (chromosome aberration test employing a the mouse bone marrow cell) being "negative" (EHC 98 (1990)), it was classified into "Not classified".
6	Carcinogenicity	Classification not possible	-	-	-	-	Since no evaluation by major international evaluation agencies is made, classification is not possible. In addition, two cases of the 104-week chronic / carcinogenicityity tests employing rats described that "the cancer incidence of the cell between testis indicated the high numerical value as compared with the control group." However, the tumor of the cell between testis occurs spontaneously in elderly rats, and the incidence may change a lot within the control. There is no proof that this tumor is malignant, and tumor generating of this type is not proved in the mouse. Therefore, it will not be thought that it is possibly generated in relation to the human exposure, even if this oncogenicity is a fact" (EHC 98 (1990)).
7	Reproductive toxicity	Classification not possible	-	-	-	-	In a reproductive toxicity study in rats it is reported that "there were no effects on the offspring at doses at which increases in liver and kidney weights and decreased weight gain and feed intake were observed in the parent animals. However, effects on the oestrous cycle and inhibition of ovulation were observed at the highest dose of 1,000 mg/kg, but there were no changes in the pregnancy rate" (EHC 98 (1990)). Since this primary document is non-public data and some details are unclear, classification is not possible.
8	Specific target organ toxicity - Single exposure	Category 2 (central nervous system)		Warning	H371: May cause damage to organs (central nervous system)	P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P405: Store locked up. P501: Dispose of contents/container to ...	EHC 98 (1990) has a description that "signs of the toxicity include excessive excitement, tremor (trembling), ataxia, and a functional fall." When one of citation (Degradation, metabolism and toxicity of synthetic pyrethroids. (1976)) is checked, we found a description that "as which irritability, ataxia, and urinary incontinence were regarded" in the single inhalation exposure test which employed the rat and the mouse. This impact was seen within the limits of the guidance value of Category 2. As mentioned above, it was classified into Category 2 (central nervous systems).
9	Specific target organ toxicity - Repeated exposure	Classification not possible	-	-	-	-	In EHC 98 (1990) it was reported that "weight reduction of the pituitary gland and thyroid/parathyroid gland and reduction of lien weight in males" were observed in a 104-week feeding study in mice. Moreover, in a 6-month feeding study in rats, it was reported that "increased serum calcium levels and reduced hepatic lipid content in males and a slight increase in urinary protein and increases in relative weight of kidneys and liver weights in males and females" within the range of guidance values for Category 2 were observed. For liver symptoms, it is pointed out that "it is an adaptive change related to the addition of corn oil to the feed" (EHC 98 (1990)). Also, for other organs no effects apart from weight loss have not been observed and no serious symptoms are thought to occur. From the above, none of these organs can be considered as target organs, but the possibility cannot be completely ruled out that exposure to this substance will affect human health, so classification is not possible.
10	Aspiration hazard	Classification not possible	-	-	-	-	Classification not possible due to lack of data

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from 96 hours LC50=0.0037mg/L of the fish (Rainbow Trout) (AQUIRE (2008)).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Since acute toxicity was Category 1 and there were no rapid degradability (not readily degradable, the decomposition by BOD: 2%(Existing Chemical Safety Inspections Data (2005))), it was classified into Category 1.