GHS Classification Result

Chemical Name：2-Chloro-4-nitroaniline
CAS：121-87-9

Result：
ID: 1-111
Classifier: Ministry of Economy, Trade and Industry （METI）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - Although the nitro group is included in chemical structure and the calculation value of oxygen balance is -116, there is no data of onset of exothermic decomposition and decomposition energy. Since it was classified into Class 6.1 and PG III in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.2237(ICSC,2000)), it was classified into Not classified.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid
5 Gases under pressure Not applicable - - - - Solid
6 Flammable liquids Not applicable - - - - Solid
7 Flammable solids Not classified - - - - Since it was classified into Class 6.1 and PG III in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.2237(ICSC,2000)), it was classified into Not classified.
8 Self-reactive substances and mixtures Not classified - - - - Since it was classified into Class 6.1 (not 4.1) and PG III in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.2237(ICSC, 2000)), it was classified into Not classified.
9 Pyrophoric liquids Not applicable - - - - Solid
10 Pyrophoric solids Not classified - - - - Even if it contacts the normal temperature air, it does not ignite spontaneously (ignition temperature 522degC (IUCLID,2000)).
11 Self-heating substances and mixtures Classification not possible - - - - The test method applicable for substances becoming liquid or gas at 140degC of test temperature has not been established.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.
13 Oxidizing liquids Not applicable - - - - Solid
14 Oxidizing solids Not classified - - - - Since it was classified into Class 6.1 and PG III in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.2237(ICSC,2000)), it was classified into Not classified.
15 Organic peroxides Not applicable - - - - The organic compound not including peroxy group in molecule.
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Although LD50 value of the oral administration test employing a rat is described to be 6,430, 6,800-10,000 mg/kg (IUCLID (2000)), 6,430 mg/kg which is a low value and is data adopted also in HSDB (2008) was adopted, and it was classified into "Not classified". In addition, in EU classification, it is Xn; R22 (EU-Annex I).
1 Acute toxicity （Dermal） Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Classification not possible due to lack of data
2 Skin corrosion/irritation Classification not possible - - - - There is a description that irritation is "slightly" shown in the 24 hour patch test with rabbits (IUCLID (2000)). Although it should be classified into "Not classified", because it was a study in many hours, classification is not possible, because it is a datum from the information source of List 2, comformance to OECD TG and GLP are unknown and there is no other data.
3 Serious eye damage/eye irritation Classification not possible - - - - Although there is a description of "not irritating" (IUCLID (2000), HSDB (2007)) in the test employing rabbits, classification is not possible due to lack of the data.
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Not classified - - - - It was classified into "Not classified" since there is a description of "not sensitizing" (IUCLID (2000)) in the Buehler test with guinea pig (OECD TG 406, GLP), and it is also adopted in HSDB (2007).
5 Germ cell mutagenicity Not classified - - - - Since there was a description of negative (IUCLID (2000)) in the body cell in vivo mutagenicity test (micronucleus test employing the erythrocyte of the hamster (OECD TG 474, GLP)), it was classified into "Not classified". In addition, although there is a negative result in the HGPRT test (OECD TG 476, GLP) employing the Chinese hamster culture cells also in the in vitro, Positive finding has been obtained in the reverse mutation test (OECD TG 471, GLP) using a Salmonella typhimurium and bacillus coli (IUCLID (2000)).
6 Carcinogenicity Classification not possible - - - - Since no evaluation by major international evaluation agencies is made and there is no data, classification is not possible.
7 Reproductive toxicity Classification not possible - - - - Classification not possible due to lack of data
8 Specific target organ toxicity - Single exposure Classification not possible - - - - Although there is a description of "only methaemoglobinaemia was seen" in the oral administration employing rats (IUCLID (2000)), since the dose is unknown, classification is not possible.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In the oral administration test to male rats, there is the description that methemoglobinemia and degeneration and functional regression in kidney, liver and testis were observed (IUCLID (2000)). Although these effects were seen outside the limits of the guidance value of Category 2, since the toxicity within the limits of the guidance value is unknown and no test data using other routes of exposure is available, classification is not possible.
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 48 hours EC50=1.7mg/L of the crustacea (Daphnia magna) (AQUIRE (2008)).
11 Hazardous to the aquatic environment （Long-term） Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Since acute toxicity was Category 2 and there were no rapid degradability (the decomposition by BOD: -4%(standard test method (4 weeks)) Existing Chemical Safety Inspections Data (2008))), it was classified into Category 2.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information