GHS Classification Result

Chemical Name:Acenaphthene
CAS:83-32-9

Result:
ID: 1-015
Classifier: Ministry of Economy, Trade and Industry (METI), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid
5 Gases under pressure Not applicable - - - - Solid
6 Flammable liquids Not applicable - - - - Solid
7 Flammable solids Classification not possible - - - - Classification not possible due to lack of data
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid
10 Pyrophoric solids Not classified - - - - Even if it contacts the normal temperature air, it does not ignite spontaneously (ignition temperature >450degC (ICSC,2006)).
11 Self-heating substances and mixtures Classification not possible - - - - The test method applicable for substances becoming liquid or gas at 140degC of test temperature has not been established.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.
13 Oxidizing liquids Not applicable - - - - Solid
14 Oxidizing solids Not applicable - - - - It is an organic compound not containing oxygen, fluorine or chlorine.
15 Organic peroxides Not applicable - - - - The organic compound not including peroxy group in molecule.
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - In the single-dose oral administration test (OECD TG 401, GLP) which employed a rat, since the fatal case was not found in the examination up to dose of 2,000 mg/kg and it was estimated to be LD50 value >2,000 mg/kg (Health, Labor and Welfare Ministry reports (Access on September 2008)), it was classified into "Not classified". In addition, although it is data in 1969, there is a report of LD50 value 10,000 mg/kg (4th volume (2005) of MOE risk assessment).
1 Acute toxicity (Dermal) Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - Classification not possible due to lack of data
2 Skin corrosion/irritation Classification not possible - - - - Although "irritation" to skin and membrane has been described (Patty (5th, 2001)), the details are unknown because of a qualitative expression, data of Hazardous Materials (NFPA), and being unable to tracing the primary literature. Moreover, there have been descriptions of "not irritating" in the skin irritation test employing rabbits (IUCLID (2000)) and "irritating" in the test with unknown animal kinds (IUCLID (2000)). Therefore, classification is not possible because of no concrete data of the degree of irritation in List1.
3 Serious eye damage/eye irritation Classification not possible - - - - Although there is a description of "not irritating" (IUCLID (2000)) in the eye irritation test employing rabbits, there is no data which denies hazard clearly in the information source of List1. As mentioned above, classification is not possible due to insufficient data.
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Classification not possible - - - - Classification is not possible since there is no data.
5 Germ cell mutagenicity Classification not possible - - - - Although there is a description of "negative" (IUCLID (2000)) in Aneuploidie Test (aneuploidy study) employing a Chinese hamster in vivo, the primary document can not be available and classification is not possible due to unknown details. There are reports of "positive" in the chromosome aberration test employing the Chinese hamster as an in vitro examination (Health, Labor and Welfare Ministry reports (Access on September 2008)) and "negative" in reverse mutation test (the Health, Labor and Welfare Ministry reports (Access on September 2008), NTP DB (Access on September 2008)).
6 Carcinogenicity Not classified - - - - Since it was estimated the group 3 (IARC 92 (2008)) by IARC, it was classified into "Not classified". In addition, IARC Monographs Vol.92 is in preparation.
7 Reproductive toxicity Classification not possible - - - - Classification is not possible because there is no data. Moreover, there is another descriptionas follows, "As a result of the 90 day forced oral administration of 0, 175, 350 and 700mg/kg to mice, significant reduction in the weight of female ovaria was observed and decline in the functions of ovaria and uterus was indicated."(MOE Risk Assessment Vol.4 (2005) but it will not be used for the classification because this description is not found in the cited literature IRIS.
8 Specific target organ toxicity - Single exposure Not classified - - - - From description of "The toxic phenomena is not seen in the test up to at dose of 2,000 mg/kg" (Health, Labor and Welfare Ministry reports (Access on September 2008)) in the acute oral toxicity test employing rats (OECD TG 401, GLP), it was classified into "Not classified ".
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In a 28-day repeated dose toxicity study in rats, "changes indicative of increased liver weight, hypertrophy of hepatocytes and effects on the liver's lipid metabolism" (Ministry of Health, Labor and Welfare Report (Access on September 2008)) were observed in male and female rats within the range of guidance values for Category 2, but since the data is insufficient classification is not possible.
10 Aspiration hazard Classification not possible - - - - Classification is not possible because there is no data. In addition, although the substance is hydrocarbon, the kinematic viscosity is unknown. Moreover, there is no description about chemical pneumonia in ICSC.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 72 hours ErC50=0.52mg/L of the algae (Pseudokirchneriella subcapitata) (EHC 202 (1998)).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Since acute toxicity was Category 1 and there were no rapid degradability (not readily degradable, the decomposition by BOD: 0% (standard test method (4 weeks)) (Existing Chemical Safety Inspections Data (1991))), it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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