GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：2-(2,4,5-Trichlorophenoxy)propionic acid; silvex
CAS：93-65-2
Result：
| ID: | 104-2 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2007 |
| Reference Manual: |
GHS Classification Manual （10 Feb, 2006） Technical Guidance Document on the GHS Classification （6 Dec, 2005） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Solid |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Solid |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Solid |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Solid |
| 7 | Flammable solids | Classification not possible | - | - | - | - | No data available. |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid |
| 10 | Pyrophoric solids | Classification not possible | - | - | - | - | No data available. |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | No data available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid |
| 14 | Oxidizing solids | Classification not possible | - | - | - | - | Classification not possible due to lack of data. |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no bivalent -O-O- structure |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 4 |
|
Warning | H302: Harmful if swallowed |
P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ... |
Based on its rat oral LD50 of 650 mg/kg (HSDB, 2005), sivex (CAS: 93-72-1) was classified into Category 4. |
| 1 | Acute toxicity （Dermal） | Category 3 |
|
Danger | H311: Toxic in contact with skin |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P280: Wear protective gloves/protective clothing/eye protection/face protection. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P322: Specific treatment （see ... on this label）. P361: Remove/Take off immediately all contaminated clothing. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on its LD50 of > 0.32E+04 mg/kg reported in a rabbit dermal test (RTECS, accessed in November 2007), classification of silvex (CAS: 93-72-1) falls under Category 4 or the "Not classified" category. More refined classification is not possible. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Since the substance is a solid, it was classified into the "Not applicable" category. |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | Silvex (CAS: 93-72-1): No data available. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Not classified | - | - | - | - | Silvex (CAS: 93-72-1): No data available. |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | Silvex (CAS: 93-72-1) is reported to be irritating to the skin (HSDB, 2005). However, since no detailed information is provided, classification is not possible. |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | Silvex (CAS: 93-72-1) is reported to be irritating to the eyes (HSDB, 2005). However, since no detailed information is provided, classification is not possible. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | MCPP (CAS: 93-65-2): No data available. |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | MCPP (CAS: 93-65-2): An open epicutaneous test using guinea pigs, gave negative results (IUCLID, 2000). However, since no other test results are available, classification is not possible. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | Silvex (CAS: 93-72-1): No data available. |
| 6 | Carcinogenicity | Category 2 |
|
Warning | H351: Suspected of causing cancer |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Since chlorophenoxy herbicides are rated as "2B" by IARC S7 (1987), the substance was classified into Category 2. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | In the study on silvex (CAS: 93-72-1), cleft palates were observed in the offspring of mice treated orally at 379 mg/kg/day during gestation (IRIS, 1988). The effect of the treatment on dams is unclear. Based on this information, the substance was classified into Category 2. |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - | - | Silvex (CAS: 93-72-1): No data available. |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | In a study in which dogs were fed with a diet containing silvex (CAS: 93-72-1) for 2 years, histological changes were observed in the liver in subject groups that received the doses which is equivalent to Category 1 doses (IRIS, 1988). Thus, the substance was classified into Category 1 (liver). |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | Silvex (CAS: 93-72-1): No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | No data available. |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | No data available. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |