GHS Classification Result

Chemical Name：2-(4-Chloro-2-methylphenoxy)propionic acid ; MCPP
CAS：93-72-1

Result：
ID: 104-1
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2007
Reference Manual: GHS Classification Manual （10 Feb, 2006）
Technical Guidance Document on the GHS Classification （6 Dec, 2005）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid
5 Gases under pressure Not applicable - - - - Solid
6 Flammable liquids Not applicable - - - - Solid
7 Flammable solids Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid
10 Pyrophoric solids Classification not possible - - - - No data available.
11 Self-heating substances and mixtures Classification not possible - - - - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid
14 Oxidizing solids Classification not possible - - - - Classification not possible due to lack of data.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on its rat oral LD50 of 1060 mg/kg (HSDB, 2003), MCPP (CAS: 93-65-2) was classified into Category 4.
1 Acute toxicity （Dermal） Classification not possible - - - - Based on its rabbit dermal LD50 of 900 mg/kg (HSDB, 2003), MCPP (CAS: 93-65-2) was classified into Category 3.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Since the substance is a solid, it was classified into the "Not applicable" category.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - MCPP (CAS: 93-65-2): No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Based on its rat LC50 of > 12.5 mg/L in a 4-hour-exposure test (IUCLID, 2000), MCPP (CAS: 93-65-2) was classified into the "Not classified" category.
2 Skin corrosion/irritation Classification not possible - - - - MCPP (CAS: 93-65-2) is reported to cause skin irritation (IUCLID, 2000). However, since no detailed information is available, classification is not possible.
3 Serious eye damage/eye irritation Classification not possible - - - - MCPP (CAS: 93-65-2) is reported to cause eye irritation (IUCLID, 2000). However, since no detailed information is available, classification is not possible.
4 Respiratory sensitization Classification not possible - - - - Silvex (CAS: 93-72-1): No data available.
4 Skin sensitization Classification not possible - - - - Silvex (CAS: 93-72-1): No data available.
5 Germ cell mutagenicity Classification not possible - - - - MCPP (CAS: 93-65-2): No data available.
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since chlorophenoxy herbicides are rated as "2B" by IARC S7 (1987), the substance was classified into Category 2.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In a developmental toxicity test in which rats were treated with MCPP (CAS: 93-65-2), increased intra-uterine deaths, decreased crown-to-rump lengths, and incomplete or absent ossification of the sternebrae were noted at doses that did not show adverse effects on dams (IRIS, 1990). However, because the administration route used in the test was not provided, classification is not possible.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - MCPP (CAS: 93-65-2): No data available.
9 Specific target organ toxicity - Repeated exposure Category 1 (liver) Danger H372: Cause damage to organs through prolonged or repeated exposure (liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In a study in which rats were fed with a diet containing MCPP (CAS: 93-65-2) for 90 days, increased absolute and relative kidney weights were noted in rat groups that received 9 mg/kg/day or higher doses (IRIS, 1990). However, since no serious histological changes were observed, based on this study alone, classification is not possible.
10 Aspiration hazard Classification not possible - - - - MCPP (CAS: 93-65-2): No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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