GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Toluene-2,4-diammonium sulfate
CAS：65321-67-7
Result：
| ID: | 82 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2007 |
| Reference Manual: |
GHS Classification Manual （10 Feb, 2006） Technical Guidance Document on the GHS Classification （6 Dec, 2005） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Solid |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Solid |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Solid |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Solid |
| 7 | Flammable solids | Classification not possible | - | - | - | - | No data available. |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid |
| 10 | Pyrophoric solids | Classification not possible | - | - | - | - | No data available. |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | No data available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid |
| 14 | Oxidizing solids | Classification not possible | - | - | - | - | It is an organic compound containing oxygen (but not fluorine or chlorine), which is chemically bonded to sulfur. Since no test results based on standardized testing methods are available, classification is not possible. |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no bivalent -O-O- structure |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 3 |
|
Danger | H301: Toxic if swallowed |
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ... |
Although there are no test results available on this substance, rat oral LD50 values for toluene-2,4-diammonium (CAS No. 95-80-7) are 73 mg/kg, 300 mg/kg (Hazard Data Book for Chemical Substance 2000-8 (CERI, 2001)), 230 mg/kg, and 270 mg/kg (DFGOT vol. 6 (1994)). Processing these documented values using a mathematical formula, we computed a representative LD50 of 135 mg/kg, which falls under Category 3. Thus, thus substance was also classified into Category 3. |
| 1 | Acute toxicity （Dermal） | Category 3 |
|
Danger | H311: Toxic in contact with skin |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P280: Wear protective gloves/protective clothing/eye protection/face protection. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P322: Specific treatment （see ... on this label）. P361: Remove/Take off immediately all contaminated clothing. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ... |
Although there are no test results available on this substance, rat dermal LD50 for toluene-2,4-diammonium (CAS No. 95-80-7) is 1,200 mg/kg (Hazard Data Book for Chemical Substance 2000-8 (CERI, 2001)) and rabbit dermal LD50 for toluene-2,4-diammonium is 650 mg/kg (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) vol. 3 (2004)). The lower LD50 value of two (650 mg/kg) falls under Category 3. Thus, this substance was also classified into Category 3. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Solid |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available. |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | No data available. As relevant background information, dermal application of toluene-2,4-diammonium (CAS No. 95-80-7) onto rabbits (24-hour application) resulted in mild irritation (Hazard Data Book for Chemical Substance 2000-8 (CERI, 2001)). Although 4-hour-application test results are not available, toluene-2,4-diammonium is considered to be a mild irritant and has been classified into Category 3. |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | No data available. As relevant background information, application of toluene-2,4-diammonium (CAS No. 95-80-7) into rabbit eyes caused moderate eye irritation and mild conjunctivitis (Hazard Data Book for Chemical Substance 2000-8 (CERI, 2001), DFGOT vol. 6 (1994)). Thus, toluene-2,4-diammonium is considered to be a moderate irritant and has been classified into Category 2A. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
| 4 | Skin sensitization | Category 1 |
|
Warning | H317: May cause an allergic skin reaction |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ... |
No test results are available for this substance. However, skin sensitization test in which toluene-2,4-diammonium (CAS No. 95-80-7) was applied to guinea pigs found it to be a "weak sensitizer" or that it "caused sensitization" (Hazard Data Book for Chemical Substance 2000-8 (CERI, 2001), DFGOT vol. 6 (1994)). Thus, toluene-2,4-diammonium is considered to be a skin sensitizer and has been classified into Category 1. Based on this information, this substance was also classified into Category 1. |
| 5 | Germ cell mutagenicity | Category 2 |
|
Warning | H341: Suspected of causing genetic defects |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
There are no test results available for this substance. However, with regard to toluene-2,4-diammonium (CAS No. 95-80-7), a dominant lethal assay, in vivo micronucleus test using somatic cell, and chromosomal aberration test gave negative results (EHC 74 (1987)) while in vivo mutation test using transgenic mice gave positive results (Mutat Re., 608, 88-96, 2006). Based on this information, this substance was classified into Category 2. |
| 6 | Carcinogenicity | Category 2 |
|
Warning | H351: Suspected of causing cancer |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Although this substance is rated as "Cat. 2" by the EU (2007), no studies supporting the rating could be identified. Since toluene-2,4-diammonium (CAS No. 95-80-7) is rated as "R" by the NTP (2005) and "Group 2B" by the IARC (1987), this substance was classified into Category 2. |
| 7 | Reproductive toxicity | Category 2 |
|
Warning | H361: Suspected of damaging fertility or the unborn child |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
There are no test results available for this substance. With regard to toluene-2,4-diammonium (CAS No. 95-80-7), there are no reports on general toxicity in parental animals, but effects on the fertility of male animals and development of fetuses were noted (EHC 74 (1987)). Based on this information, this substance was classified into Category 2. |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (liver, central nervous system, blood system), Category 3 (respiratory tract irritation) |
|
Danger Warning |
H370: Causes damage to organs (liver, central nervous system, blood system) H335: May cause respiratory irritation (respiratory tract irritation) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. |
There are no test results available for this substance. However, in human and animal experiments, application of toluene-2,4-diammonium (CAS No. 95-80-7) was associated with effects on the liver, central nervous system, and blood system, and respiratory tract irritation. These effects seen in animal experiments occurred at doses that fall under Category 1 (Hazard Data Book for Chemical Substance 2000-8 (CERI, 2001)). Based on these results on toluene-2,4-diammonium, this substance was also classified into Category 1 for the liver, central nervous system, and blood system, and Category 3 for respiratory irritation. |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (liver, kidney), Category 2 (blood system, spleen, testis) |
|
Danger Warning |
H372: Cause damage to organs through prolonged or repeated exposure (liver, kidney) H373: May cause damage to organs through prolonged or repeated exposure (blood system, spleen, testis) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
There are no test results available for this substance. However, in animal experiments, application of toluene-2,4-diammonium (CAS No. 95-80-7) affected the liver and kidney (at doses that fall under Category 1), as well as the blood system, spleen, testes (at doses that fall under Category 2) (Hazard Data Book for Chemical Substance 2000-8 (CERI, 2001)). Based on these results on toluene-2,4-diammonium, this substance was also classified into Category 1 (liver and kidney) and Category 2 (blood system, spleen, and testis). |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | No data available. |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | No data available. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |