GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：R-2,3-Epoxy-1-propanol
CAS：57044-25-4
Result：
| ID: | 79 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2007 |
| Reference Manual: |
GHS Classification Manual （10 Feb, 2006） Technical Guidance Document on the GHS Classification （6 Dec, 2005） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Category 4 | - | Warning | H227: Combustible liquid |
P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ... |
1) Since its flash point reported by ICSC is 72degC (closed cup), the substance was classified into Category 4 (RS isomers). 2) UN 2351, Class 3 (RS isomers). |
| 7 | Flammable solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Classification not possible | - | - | - | - | It contains chemical groups (epoxy group) associated with self-reactive properties. Since no test results are available, classification is not possible. (The EU's Risk Phrase for this substance is R2: risk of explosion by shock, friction, fire or other sources of ignition.) |
| 9 | Pyrophoric liquids | Not classified | - | - | - | - | Since its autoignition point is 415degC (ICSC), the substance does not ignite at room temperature. |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | No data available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no bivalent -O-O- structure |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Classification not possible due to lack of data. (The EU's Risk Phrase for this substance is R34: causes burns.) |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 4 |
|
Warning | H302: Harmful if swallowed |
P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ... |
Although there are no test results available for its R isomers, rat oral LD50 for 2,3-epoxy-1-propanol (CAS No. 556-52-5) is 420 mg/kg (Hazard Data Book for Chemical Substance (CERI, 2002)). Therefore, the substance was classified into Category 4. |
| 1 | Acute toxicity （Dermal） | Category 4 |
|
Warning | H312: Harmful in contact with skin |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P280: Wear protective gloves/protective clothing/eye protection/face protection. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P322: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ... |
Although there are no test results available for its R isomers, rabbit dermal LD50 for 2,3-epoxy-1-propanol (CAS No. 556-52-5) is 1980 mg/kg (Hazard Data Book for Chemical Substance (CERI, 2002), Patty 5th (2001)). Therefore, the substance was classified into Category 4. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Category 3 |
|
Danger | H331: Toxic if inhaled |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P311: Call a POISON CENTER or doctor/physician. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
Although there are no test results available for its R isomers, rat inhalation exposure (4 hours) LC50 for 2,3-epoxy-1-propanol (CAS No. 556-52-5) is 580 mg/kg (Hazard Data Book for Chemical Substance (CERI, 2002), Patty 5th (2001)). Therefore, the substance was classified into Category 3. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available. |
| 2 | Skin corrosion/irritation | Category 2 |
|
Warning | H315: Causes skin irritation |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P362: Take off contaminated clothing and wash before reuse. |
Although there are no test results available for its R isomers, severe irritation was noted in a test in which 2,3-epoxy-1-propanol (CAS No. 556-52-5) was applied onto rabbit skin (Hazard Data Book for Chemical Substance (CERI, 2002), Patty 5th (2001)). Therefore, the substance was classified into Category 2. |
| 3 | Serious eye damage/eye irritation | Category 2A |
|
Warning | H319: Causes serious eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. |
Although there are no test results available for its R isomers, severe irritation was noted in a test in which 2,3-epoxy-1-propanol (CAS No. 556-52-5) was applied into rabbit eyes (Hazard Data Book for Chemical Substance (CERI, 2002), Patty 5th (2001)). Therefore, the substance was classified into Category 2A. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available. |
| 5 | Germ cell mutagenicity | Category 2 |
|
Warning | H341: Suspected of causing genetic defects |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Since chromosomal aberrations and sister chromatid exchanges were seen in a test using mouse bone marrow (RTECS, accessed in November 2007), the substance was classified into Category 2. As additional background information, in vitro reverse mutation tests also gave positive results (RTECS, accessed in November 2007). |
| 6 | Carcinogenicity | Category 1B |
|
Danger | H350: May cause cancer |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
2,3-epoxy-1-propanol (CAS No. 556-52-5) is rated as "Group 2A" by the IARC and "2A" by Japan Society for Occupational Health (IARC 77 (2000), Recommendations of Occupational Exposure Limits (2004)). Based on these ratings, the substance was classified into Category 1B. |
| 7 | Reproductive toxicity | Category 2 |
|
Warning | H361: Suspected of damaging fertility or the unborn child |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Although there are no test results available for this substance, oral administration of 2,3-epoxy-1-propanol (CAS No. 556-52-5) to rats resulted in decreased number of sperm, atrophy of the testes, and reproductive disturbance in male rats (Hazard Data Book for Chemical Substance (CERI, 2002), DFGOT vol. 20 (2003)). The effect of the administration on parental animals was not clear. Based on these results, this substance was classified into Category 2. |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (central nervous system), Category 3 (respiratory tract irritation) |
|
Danger Warning |
H370: Causes damage to organs (central nervous system) H335: May cause respiratory irritation (respiratory tract irritation) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. |
Although there are no test results available for this substance, 2,3-epoxy-1-propanol (CAS No. 556-52-5) was associated with tremors and effects on the central nervous system in oral administration tests using rats. In addition, inhalation exposure to 2,3-epoxy-1-propanol resulted in irritation to the respiratory system (Hazard Data Book for Chemical Substance (CERI, 2002)). Since these effects were seen at doses that fall under Category 1 guidance values, this substance was classified into Category 1 for the central nervous system and Category 3 for respiratory tract irritation. |
| 9 | Specific target organ toxicity - Repeated exposure | Category 2 (central nervous system, kidney, spleen, liver, digestive system) |
|
Warning | H373: May cause damage to organs through prolonged or repeated exposure (central nervous system, kidney, spleen, liver, digestive system) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Although there are no test results available for this substance, in animal tests, 2,3-epoxy-1-propanol (CAS No. 556-52-5) was associated with demyelination of the brain, degeneration and necrosis of the tubular epithelium in the kidney, fibrosis of the spleen, clotting and necrosis of the liver, and hyperplasia of epithelium in the forestomach mucosa (Hazard Data Book for Chemical Substance (CERI, 2002)). These effects were noted at doses that fall under Category 2 guidance values. Thus, this substance was classified into Category 2 (central nervous system, kidney, spleen, liver, and digestive system). |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | No data available. |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | No data available. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |