Chemical Name:1-Nitropyrene
CAS:5522-43-0
ID: | 61 |
Classifier: | Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE) |
Year Classified: | FY2007 |
Reference Manual: |
GHS Classification Manual (10 Feb, 2006) Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
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1 | Explosives | Not classified | - | - | - | - | It contains chemical groups (nitro group) associated with explosive properties and its oxygen balance is calculated to be -223. Based on this information, the substance was classified into the "Not classified" category. |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | - | Solid (GHS definition) |
3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (GHS definition) |
5 | Gases under pressure | Not applicable | - | - | - | - | Solid (GHS definition) |
6 | Flammable liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
7 | Flammable solids | Classification not possible | - | - | - | - | No data available. |
8 | Self-reactive substances and mixtures | Classification not possible | - | - | - | - | It contains chemical groups (nitro group) associated with explosive properties. Since no test results are available, classification is not possible. |
9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
10 | Pyrophoric solids | Classification not possible | - | - | - | - | No data available. |
11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | No data available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
14 | Oxidizing solids | Classification not possible | - | - | - | - | It is an organic compound containing oxygen (but not fluorine or chlorine), which is chemically bonded to nitrogen. Since no test results based on standardized testing methods are available, classification is not possible. |
15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no bivalent -O-O- structure |
16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available. |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
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1 | Acute toxicity (Oral) | Not classified | - | - | - | - | Since its rat LD50 is > 5000 mg/kg in oral administration test (EHC 229 (2003)), the substance was classified into the "Not classified" category. |
1 | Acute toxicity (Dermal) | Classification not possible | - | - | - | - | No data available. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | - | Since the substance is a solid (GHS definition), it was classified into the "Not applicable" category. |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible | - | - | - | - | No data available. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible | - | - | - | - | No data available. |
2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | No data available. |
3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | No data available. |
4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
4 | Skin sensitization | Classification not possible | - | - | - | - | No data available. |
5 | Germ cell mutagenicity | Category 2 | Warning | H341: Suspected of causing genetic defects |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
This substance was tested in a number of animal tests and their results follow: sister chromatid exchange was seen in rats and DNA damage was noted in mice (IARC vol. 46 (1989), EHC 229 (2003)); though observations were limited, DNA adducts and micronuclei were found in rat lung cells (EHC 229 (2003)); and furthermore, a series of in vitro mutagenicity tests yielded positive results (IARC vol. 46 (1989), EHC 229 (2003)). Based on these results, the substance was classified into Category 2. | |
6 | Carcinogenicity | Category 2 | Warning | H351: Suspected of causing cancer |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
It is rated as "Group 2B" by the IARC (IARC vol. 46 (1989)) and "R" by the NTP (NTP 2005). Based on these ratings, the substance was classified into Category 2. | |
7 | Reproductive toxicity | Classification not possible | - | - | - | - | No data available. |
8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - | - | In an oral administration test using rats, there is a report that no toxic effects of the substance, including histopathological alterations, on organs were observed at a dose of 5000 mg/kg (EHC 229 (2003)). Since no other test results are available, the substance was classified into the "Classification not possible" category. |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (respiratory system) | Danger | H372: Cause damage to organs through prolonged or repeated exposure (respiratory system) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
In an inhalation exposure test using rats, squamous metaplasia of the epiglottis was noted at doses that fall under Category 1 (EHC 229 (2003)). Thus, the substance was classified into Category 1 (respiratory system). | |
10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available. |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Not classified | - | - | - | - | Since the substance is not toxic to algae, crustaceans, and fish at concentrations near its water solubility of 0.0118 mg/L (SRC, 2005), it was classified into the "Not classified" category. |
11 | Hazardous to the aquatic environment (Long-term) | Category 4 | - | - | H413: May cause long lasting harmful effects to aquatic life |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
It is poorly water-soluble and it is reported to be not acutely toxic at concentrations up to its water solubility (0.0118 mg/L). In addition, it is not rapidly degradable (BIOWIN 2007), logPow = 5.06 (SRC 2005), and NOEC is < 1 mg/L. Based on this information, the substance was classified into Category 4 for chronic toxicity. |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website (in Japanese Only) |
Model SDS by MHLW |
MHLW Website (in Japanese Only) |