GHS Classification Result

Chemical Name:p-(Trichloromethyl)chlorobenzene; p-chlorobenzotrichloride
CAS:5216-25-1

Result:
ID: 60
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2007
Reference Manual: GHS Classification Manual (10 Feb, 2006)
Technical Guidance Document on the GHS Classification (6 Dec, 2005)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Classification not possible - - - - No data available.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Classification not possible - - - - No data available.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance contains chlorine (but not fluorine or oxygen), which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Its rat LD50 values obtained through oral administration are reported to be 652, 581, 685, and 1350 mg/kg (DFGOT vol. 10 (1998)). These values were statistically processed to obtain the representative LD50 of 581 mg/kg. Based on this value, the substance was classified into Category 4.
1 Acute toxicity (Dermal) Category 4 Warning H312: Harmful in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
Since its rabbit LD50 = 1900 mg/kg (DFGOT vol. 10, 1998), the substance was classified into Category 4.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Since the substance is a liquid (GHS definition), it was classified into the "Not applicable" category.
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - Its rat LD50 is reported to be 0.125 mg/L (DFGOT vol. 10, 1998). However, since exposure time is not provided, classification is not possible.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P362: Take off contaminated clothing and wash before reuse.
In rabbits that were treated dermally with the substance for 24 hours, whitening of the skin and moderate to severe edema were observed. During the following 8 days the skin dried out and discoloration developed (DFGOT vol. 10 (1998)). Thus, the substance was classified into Category 2.
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
In rabbits that were treated dermally with the substance for 24 hours, conjunctival edema was present in 4 of the 6 animals 8 days later (DFGOT vol. 10 (1998)). From these results, the substance was classified into Category 2A.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - This substance is reported to be sensitizing in animal tests (DFGOT vol. 10 (1998)). However, since the test methods, animal species used, and number of animals were not clarified, the substance was classified into the "Classification not possible" category due to insufficient data available.
5 Germ cell mutagenicity Classification not possible - - - - Positive results are reported in Ames tests and in vitro chromosomal aberration tests (DFGOT vol. 10 (1998)). However, since no appropriate in vivo test results are available, classification is not possible.
6 Carcinogenicity Classification not possible - - - - It is rated as "2" by the EU (EU 2007). In animal experiments, it is reported that female mice that received dermal or oral administration of the substance developed tumors in the skin, forestomach, and lungs (DFGOT vol. 10 (1998)). However, since there are no other test results available, the substance was classified into the "Classification not possible" category due to insufficient data available.
7 Reproductive toxicity Classification not possible - - - - In reproductive and developmental toxicity tests using rats that received the substance via oral administration or inhalation exposure, seminal duct atrophy and increase in cervical ribs in the offspring were found (DFGOT vol. 10 (1998)). However, the relevance of these findings to reproductive and developmental toxicity is not clear. Thus, the substance was classified into the "Classification not possible" category due to insufficient data available available.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - In oral administration or inhalation exposure tests using rats, posture disorder, protrusion of the eyes, dilated pupils, and changes in the lungs and liver were noted at doses around LD50 (DFGOT vol. 10 (1998)). However, since no explanations on doses used and presence/absence of mortality were provided, the substance was classified into the "Classification not possible" category due to insufficient test results available.
9 Specific target organ toxicity - Repeated exposure Category 1 (central nervous system, testis, liver, respiratory system) Danger H372: Cause damage to organs through prolonged or repeated exposure (central nervous system, testis, liver, respiratory system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
In oral administration or inhalation exposure tests using rats, central nervous effects, testicular atrophy, changes in the liver, and changes in the respiratory system were noted at doses that fall under Category 1 (DFGOT vol. 10 (1998)). Based on these results, the substance was classified into Category 1 (central nervous system, testis, liver, and respiratory system).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
Since its 96-hour LC50 is 26.5 mg/L for fish (Branchydanio rerio) (IUCLID, 2000), the substance was classified into Category 3 for acute toxicity.
11 Hazardous to the aquatic environment (Long-term) Category 3 - - H412: Harmful to aquatic life with long lasting effects P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
Its classification for acute toxicity is Category 3, it is not rapidly degradable (BIOWIN, 2007), and logPow = 4.54 (SRC, 2005). Based on this information, the substance was classified into Category 3 for chronic toxicity.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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