GHS Classification Result

Chemical Name：Mirex
CAS：2385-85-5

Result：
ID: 54
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2007
Reference Manual: GHS Classification Manual （10 Feb, 2006）
Technical Guidance Document on the GHS Classification （6 Dec, 2005）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available.
11 Self-heating substances and mixtures Classification not possible - - - - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - The substance contains chlorine (but not oxygen or fluorine), which is chemically bonded only to carbon or hydrogen.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on the report that female rat LD50 = 600 mg/kg (corn oil) (IARC 20, 1979), the substance was classified into Category 4.
1 Acute toxicity （Dermal） Category 4 Warning H312: Harmful in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Based on the report that LD50 for both female and male rats is 2000 mg/kg (EHC 44, 1984), the substance was classified into Category 4.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		Based on the report that it is a moderate skin irritant (HSDB, 2007), the substance was classified into Category 2.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Not classified - - - - Based on the report that a dominant lethal assay in mice gave negative results (IARC 20 (1979)), the substance was classified into the "Not classified" category.
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It is rated as "Group 2B" by the IARC (1987), "2B" by Japan Society for Occupational Health (2007), and "R" by the U.S. NTP (2005), the substance was classified into Category 2.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		IARC 20 (1979) documented the following: in female mice fed with a diet containing this substance before and after the mating period, litter sizes decreased; in female rats fed with a diet containing this substance before and after the mating period, survival rates of the offspring decreased and cataracts were noted at high frequencies in the offspring; and in female rats fed with a diet containing this substance on days 6-15 of gestation, decreased pregnancy rates, fetal survival rates, fetal body weights, and abnormalities of the organs of the fetuses were noted at doses that did not induce toxic symptoms in parental animals. In these reports, neither doses that induced effects in parental animals nor the kinds of effects noted in parental animals can be identified. Thus, we classified the substance into Category 2.
8 Specific target organ toxicity - Single exposure Category 1 (liver, eye, nervous system) Danger H370: Causes damage to organs (liver, eye, nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		The following animal test results have been documented: in mice that received oral administration, vacuolation of hepatocytes were noted; in rats that received oral administration, hepatic glycogen depletion and periportal liposis were detected; cataracts were produced in newborn rats that received oral administration; and in rats that received oral administration, lethargy, weakness, hyper excitability, and tremors were observed (ATSDR, 1995). Evaluating these reports, we determined that the liver, eyes, and nervous system are the target organs for this substance, and all effects on test animals were seen at doses that fall under the range of Category 1 guidance values. Thus, the substance was classified into Category 1 (liver, eyes, and nervous system).
9 Specific target organ toxicity - Repeated exposure Category 1 (liver, nervous system) Danger H372: Cause damage to organs through prolonged or repeated exposure (liver, nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		The following animal test results have been documented: in a two-year mixed diet administration test using rats, fatty metamorphosis in the liver, cytomegaly, angiectasis, and hepatocellular necrosis were noted (NTP TR 313, 1990). Rats that were treated with this substance exhibited hypoactivity, irritability, and tremors (ATSDR, 1995). Evaluating these reports, we determined that the liver and nervous system are the target organs for this substance, and all effects on test animals were seen at doses that fall under the range of Category 1 guidance values. Thus, the substance was classified into Category 1 (liver and nervous system).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Since its 96-hour LC50 for fish (rainbow trout) is 0.023 mg/L (ECOTOX, 2007), the substance was classified into Category 1 for acute toxicity.
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Its classification for acute toxicity is Category 1, it is not rapidly degradable (BIOWIN 2007), and logPow = 6.89 (SRC 2005). Based on this information, the substance was classified into Category 1 for chronic toxicity.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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