GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：2-Amino-4,6-dinitrophenol
CAS：96-91-3
Result：
| ID: | 07-D39 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2007 |
| Reference Manual: |
GHS Classification Manual （10 Feb, 2006） Technical Guidance Document on the GHS Classification （6 Dec, 2005） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Classification not possible | - | - | - | - | The pure form of this substance is known to explode very violently (Bretherick). The substance prepared as synthetic raw materials or analytical reagents have apparently not been evaluated for its explosive properties, and thus, it was classified into the "Classification not possible" category. (The substance wetted with 20% water by mass is defined as Division 4.1, packing group I (UN 3376) by the UNRTDG and categorized into desensitized explosives.) |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Solid (GHS definition) |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 7 | Flammable solids | Category 1 |
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Danger | H228: Flammable solids |
P370+P378: In case of fire: Use ... for extinction. P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P280: Wear protective gloves/protective clothing/eye protection/face protection. |
Based on the report that the substance, in contact with an open flame in a glass tube or beaker, ignites rapidly and burns relatively quickly (HSDB (2003)), it was classified into Category 1. |
| 8 | Self-reactive substances and mixtures | Classification not possible | - | - | - | - | The report that the substance may explode when shocked or heated; it is a powerful explosive when dry (HSDB (2003)) indicates that the substance is a self-reactive substance. However, categorization of the substance is not clear in accordance with GHS definition and thus, it was classified into the "Classification not possible" category. |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 10 | Pyrophoric solids | Classification not possible | - | - | - | - | Its melting point is 168degC (Gangolli vol. 1 (1st. 1992) and flash point is 210degC (Merck (14th, 2006)). Since no additional information is available, the substance was classified into the "Classification not possible" category. |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | No data available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb,Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 14 | Oxidizing solids | Classification not possible | - | - | - | - | No data available. |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Containing no bivalent -O-O- structure in the molecule |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Classification not possible | - | - | - | - | No data available. Notes: According to GHS classification of dinitrophenol by the Japanese Government, oral doses of 3 to 46 mg/kg (ATSDR, 1995) or 1 to 3 g (which are equivalent to 17 to 50 mg/kg assuming the body weight of 60 kg) are considered to be lethal in humans (HSDB, 2003). Based on these reports, the substance was classified into Category 2. |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available. Notes: According to GHS classification of dinitrophenol by the Japanese Government, the substance is classified into the "Classification not possible" category due to lack of test results. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available. Notes: According to GHS classification of dinitrophenol by the Japanese Government, no test results are available. It is reported that inhalation of DNP dusts is highly poisonous (HSDB (2003), and humans breathing in air containing 40 mg DNP /m3 for long periods of time have died (ATSDR (1995)). |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | No data available. |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | No data available. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | According to NTP DB (2007) and other sources, an Ames test yielded positive results. However, since no other information on mutagenicity of the substance is available, classification is not possible. |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | No data available. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | No data available. |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - | - | No data available. Notes: According to GHS classification of dinitrophenol, which is similar in chemical structure to this substance, by the Japanese Government, dinitrophenol is classified into Category 1 for its systemic toxicity in humans (increased oxygen consumption due to the elevation of the metabolic rate at cellular level, increased respiratory rate and pulsation, and elevation of body temperature) and its toxic effects on the nervous system, blood system (a decrease of certain types of white blood cells), and eyes (cataracts) as reported in Priority 1 documents (ATSDR (1995)) (similar reports are found also in PATTY (5th, 2001), HSDB (2003), and HSFS (2003)). In addition, dinitrophenol is also classified into Category 2 for its toxic effects on the kidney and liver and Category 3 for respiratory tract irritation since these effects and irritation in humans are reported in Priority 2 documents (HSDB (2003), HSFS (2003)). |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | No data available. Notes: According to GHS classification of dinitrophenol, which is similar in chemical structure to this substance, by the Japanese Government, dinitrophenol is classified into Category 1 for its systemic toxicity in humans (increased oxygen consumption due to the elevation of the metabolic rate at cellular level, increased respiratory rate and pulse, and elevation of body temperature) and its toxic effects on the nervous system, blood system (a decrease of certain types of white blood cells), and eyes (cataracts) as reported in Priority 1 documents (ATSDR (1995)). In addition, dinitrophenol is classified into Category 1 for its toxic effects on the kidney (by four isomers of 2,3-; 2,5-; 3,4-; and 3,5-dinitrophenol) and liver in humans (PATTY (5th, 2001)). |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 3 | - | - | H402: Harmful to aquatic life |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
Based on its 96-hour LC50 of 46.2 mg/L for fish (rainbow trout) (AQUIRE, 2007), the substance was classified into Category 3. |
| 11 | Hazardous to the aquatic environment （Long-term） | Category 3 | - | - | H412: Harmful to aquatic life with long lasting effects |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
Its classification for acute toxicity is Category 3, its potential for bioconcentration is estimated to be low (a bioconcentration factor value in rainbow trout was 42 (HSDB, 2007)), and it is estimated not to be rapidly degradable (BIOWIN). Based on this information, the substance was classified into Category 3. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |