GHS Classification Result

Chemical Name：p-Nitrosodimethylaniline
CAS：138-89-6

Result：
ID: 07-D29
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2007
Reference Manual: GHS Classification Manual （10 Feb, 2006）
Technical Guidance Document on the GHS Classification （6 Dec, 2005）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - Although it contains chemical groups (nitroso group) associated with explosive properties, based on the calculated oxygen balance (-213.08 < -200), the substance was classified into the "Not classified" category.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Type G - - - - Although it contains chemical groups (nitroso group) associated with explosive properties, it is rated as UN1369, Division 4.2 II, which indicates that the substance is non-hazardous in terms of self-reactivity. Based on this information, the substance was defined as Type G.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Since the substance is classified into Category 1 as a self-heating substance, it was classified into the "Not classified" category.
11 Self-heating substances and mixtures Category 1 Danger H251: Self-heating; may catch fire P235+P410: Keep cool. Protect from sunlight.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P407: Maintain air gap between stacks/pallets.
P413: Store bulk masses greater than ... kg/... lbs at temperatures not exceeding ... degC/... degF.
P420: Store away from other materials. 		The substance is rated as the UNRTDG's Division 4.2, packing group II (UN 1369). Based on this rating, it was classified into Category 1.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb,Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not classified - - - - It contains oxygen bonded to nitrogen. However, it is rated as UN1369, Division 4.2 II and is a non-hazardous substance in terms of oxidizing properties. Thus, it was classified into the "Not classified" category.
15 Organic peroxides Not applicable - - - - Containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Classification not possible - - - - Classification not possible due to lack of data.
1 Acute toxicity （Dermal） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		In light of reports that contact can irritate the skin and eyes (HSFS (2002)) and that it is highly irritating to skin (HSDB (2003)), the substance was classified into Category 2.
3 Serious eye damage/eye irritation Classification not possible - - - - Regarding this substance, it is reported that contact can irritate the skin and eyes (HSFS (2002)). However, since no other information is available, the substance was classified into the "Classification not possible" category.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - It is reported that p-nitrosodimethylaniline may cause a skin allergy (HSFS (2002)) and that the substance causes skin sensitization in guinea pigs (HSDB (2003)). However, no supportive evidence was provided regarding the HSFS report, and no detailed test methods were provided regarding the HSDB report. Furthermore, the HSDB report added that the animal initially became sensitive to the compound, but 1-2 weeks later the guinea pig became insensitive to it. This statement raises the question of whether or not the substance is really sensitizing and thus we classified it into the "Classification not possible" category.
5 Germ cell mutagenicity Classification not possible - - - - All reverse mutation tests using bacteria have yielded positive results (NTPDB (accessed in July 2007), RTECS (accessed in July 2007), HSDB (2003)). However, since no other information is available, classification is not possible.
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Rat oral administration tests (RTECS (accessed in July 2007)) and rat or mouse oral administration tests via drinking water (HSDB (2003)) found the substance carcinogenic. In addition, the substance was found carcinogenic in other animal tests (HSFS (2002)). Considering that the test substance is a nitroso compound, it was classified into Category 2 with the expert judgement.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - It is reported that high exposure may affect the nervous system causing weakness, tremors, drowsiness, fatigue, nervousness and confusion (HSFS (2002)). However, since no other information is available, the substance was classified into the "Classification not possible" category.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Classification not possible due to lack of data.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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