GHS Classification Result

Chemical Name：Nitroguanidine
CAS：556-88-7

Result：
ID: 07-D22
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2007
Reference Manual: GHS Classification Manual （10 Feb, 2006）
Technical Guidance Document on the GHS Classification （6 Dec, 2005）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Division 1.1 Danger H201: Explosive; mass explosion hazard P370+P380: In case of fire: Evacuate area.
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P230: Keep wetted with ...
P240: Ground/bond container and receiving equipment.
P250: Do not subject to grinding/shock/.../friction.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P372: Explosion risk in case of fire.
P374: Fight fire with normal precautions from a reasonable distance.
P401: Store ...
P501: Dispose of contents/container to ... 		Since the substance, which is dry or wetted with less than 20% water by mass, is defined as UN0282 and Division 1.1, it was classified into Division 1.1. (If the substance is wetted with not less than 20% water by mass, it is defined as UN1336 and a desensitized explosive. Based on this information it was classified into the "Not classified" category.)
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - Since the substance is classified as an explosive, classification as a self-reactive substance is not applicable.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Since its autoignition point is reported to be 257degC (5 seconds) (The Society of Synthetic Organic Chemistry, Japan Dictionary of Organic Compounds, Kodansha Ltd. (1985) p.669-670), we determined that the substance does not ignite spontaneously in contact with air at room temperature and classified it into the "Not classified" category.
11 Self-heating substances and mixtures Classification not possible - - - - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb,Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - No data available.
15 Organic peroxides Not applicable - - - - Containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Based on the rat LD50 of 10200 mg/kg (RTECS (accessed in August 2007)), the substance was classified into the "Not classified" category.
1 Acute toxicity （Dermal） Not classified - - - - The documented lethal dose for rabbits of > 2000 mg/kg (RTECS (accessed in August 2007)) indicates that no mortality would result by a dose as high as the upper limit of the Category 4 guidance range. Thus, the substance was classified into the "Not classified" category.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - No data available.
3 Serious eye damage/eye irritation Category 2A-2B Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		A 24-hour exposure of the substance to the eyes of rabbits resulted in strong irritation (RTECS (accessed in August 2007)). However, since degrees of irritation by 4-hour exposure have not been reported, the substance was classified into Category 2A-2B.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Not classified - - - - In vitro tests using cultured bacteria or mammalian cells gave negative results and in vivo assays using mouse or rat germ cells also yielded negative results (HSDB (2003)). Based on these negative results, the substance was classified into the "Not classified" category.
6 Carcinogenicity Not classified - - - - Since the substance is rated as Class D; not classifiable as a human carcinogen, by the EPA (IRIS (1993)), it was classified into the "Not classified" category.
7 Reproductive toxicity Not classified - - - - In a rat teratogenicity test, no evidence of developmental toxicity or teratogenic effects were noted at doses that did not show signs of maternal toxicity (IRIS (1993)). In a rabbit teratogenicity test, a slight increase in incidence of resorptions was noted in all dose groups, but no teratogenic effects were noticed (IRIS (1993)). On the basis of these findings, there is weak to equivocal evidence for potential developmental toxicity (IRIS (1993)). In addition, in a two-generation reproduction study using rats, no signs of toxic effects on fertility or development of the offspring were noted (HSDB (2003)). Based on these negative results, the substance was classified into the "Not classified" category.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Not classified - - - - In 90-day oral administration tests using rats or mice that were fed a diet containing this substance, the NOAEL was reported to be 316 mg/kg/day for both animal species (IRIS (1993)). Because this value is above the upper limit of the Category 2 guidance values, the substance was classified into the "Not classified" category.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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