Chemical Name:Powder cake (2) [composition: nitroglycerin/nitrocellulose/isopropyl alcohol = 60/23/17]
CAS:
ID: | 07-D14-2 |
Classifier: | Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE) |
Year Classified: | FY2007 |
Reference Manual: |
GHS Classification Manual (10 Feb, 2006) Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Explosives | Division 1.1 | Danger | H201: Explosive; mass explosion hazard |
P370+P380: In case of fire: Evacuate area. P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking. P230: Keep wetted with ... P240: Ground/bond container and receiving equipment. P250: Do not subject to grinding/shock/.../friction. P280: Wear protective gloves/protective clothing/eye protection/face protection. P372: Explosion risk in case of fire. P374: Fight fire with normal precautions from a reasonable distance. P401: Store ... P501: Dispose of contents/container to ... |
It is rated as UN0433 and Division 1.1. | |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | - | Solid |
3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable | - | - | - | - | Solid |
5 | Gases under pressure | Not applicable | - | - | - | - | Solid |
6 | Flammable liquids | Not applicable | - | - | - | - | Solid |
7 | Flammable solids | Classification not possible | - | - | - | - | No data available. |
8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | Since the substance is classified as an explosive, classification as a self-reactive substance is not applicable. |
9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid |
10 | Pyrophoric solids | Classification not possible | - | - | - | - | No data available. |
11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | No data available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metalloids. |
13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid |
14 | Oxidizing solids | Classification not possible | - | - | - | - | No data available. |
15 | Organic peroxides | Not applicable | - | - | - | - | Containing no bivalent -O-O- structure in the molecule |
16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available. |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 3 | Danger | H301: Toxic if swallowed |
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment (see ... on this label). P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ... |
The LD50 for rats given to nitroglycerin is 100 mg/kg (Japanese Government's classification) and that for rats given to isopropyl alcohol is 3437 mg/kg (Japanese Government's classification). Based on these values, the LD50 for this compound was computed to be 127.3 mg/kg and was classified into Category 3. | |
1 | Acute toxicity (Dermal) | Classification not possible | - | - | - | - | Since no test results on nitroglycerin are available, classification is not possible (Japanese Government's classification). Nitrocellulose is classified into the "Not classified" category based on its LD50 of > 29200 (Japanese Government's classification). And LD50 of isopropyl alcohol is 4050 mg/kg. Giving a priority to the classification of nitroglycerin over that of other two components, this compound was classified into the "Classification not possible" category. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | - | Solid |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible | - | - | - | - | Since both nitroglycerin and nitrocellulose are classified into the "Classification not possible" category, this compound was classified into the "Classification not possible" category. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible | - | - | - | - | Since all components are classified into the "Classification not possible" category, this compound was classified into the "Classification not possible" category. |
2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | Since both nitroglycerin and nitrocellulose are classified into the "Classification not possible" category, this compound was classified into the "Classification not possible" category. |
3 | Serious eye damage/eye irritation | Category 2A-2B | Warning | H319: Causes serious eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. |
Because nitroglycerin and isopropyl alcohol are classified into Category 2A-2B, this compound was also classified into Category 2A-2B assuming the same cutoff values. | |
4 | Respiratory sensitization | Classification not possible | - | - | - | - | Since all components are classified into the "Classification not possible" category, this compound was classified into the "Classification not possible" category. |
4 | Skin sensitization | Category 1 | Warning | H317: May cause an allergic skin reaction |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment (see ... on this label). P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ... |
Since nitroglycerin is classified into Category 1, this compound was classified into Category 1 assuming the same cutoff values. | |
5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | Since nitrocellulose is classified into the "Classification not possible" category, this compound was also classified into the "Classification not possible" category. |
6 | Carcinogenicity | Classification not possible | - | - | - | - | Since both nitroglycerin and nitrocellulose are classified into the "Classification not possible" category, this compound was classified into the "Classification not possible" category. |
7 | Reproductive toxicity | Category 2 | Warning | H361: Suspected of damaging fertility or the unborn child |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Because nitroglycerin and isopropyl alcohol are classified into Category 2, this compound was also classified into Category 2 assuming the same cutoff values. | |
8 | Specific target organ toxicity - Single exposure | Category 1 (cardiovascular system, blood, central nervous system, kidney, systemic toxicity), Category 3 (respiratory tract irritation) |
Danger Warning |
H370: Causes damage to organs (cardiovascular system, blood, central nervous system, kidney, systemic toxicity) H335: May cause respiratory irritation (respiratory tract irritation) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment (see ... on this label). P405: Store locked up. P501: Dispose of contents/container to ... P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. |
Nitroglycerin is classified into Category 1 for its toxicity to the cardiovascular system and blood, and isopropyl alcohol is classified into Category 1 for its central nervous system, kidney, and systemic toxicity. Thus, assumining the same cutoff values, this compound was classified into Category 1 (cardiovascular system, blood, central nervous system, kidney, and systemic toxicity). Since both compounds, nitrocellulose and isopropyl alcohol, are classified into Category 3 for its respiratory irritation. Thus, assuming the same cutoff values, this compound was classified into Category 3 (respiratory tract irritation). | |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (cardiovascular system), Category 2 (liver, spleen) |
Danger Warning |
H372: Cause damage to organs through prolonged or repeated exposure (cardiovascular system) H373: May cause damage to organs through prolonged or repeated exposure (liver, spleen) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Since nitroglycerin is classified into Category 1 for its toxicity to the cardiovascular system, the substance was classified into Category 1 (cardiovascular system) assuming the same cutoff point. Isopropyl alcohol is classified into Category 2 for its toxicity to the blood vessel, liver, and spleen, this compound was classified into Category 2 (liver and spleen) (the blood vessel is included in Category 1 and excluded from Category 2). | |
10 | Aspiration hazard | Classification not possible | - | - | - | - | The toxic effect of Isopropyl alcohol (Category 2) is suspected to contribute to the toxicity of this compound. However, since kinematic viscosity of this compound is unknown, it was classified into the "Classification not possible" category. |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 2 | - | - | H401: Toxic to aquatic life |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
Regarding nitroglycerin (CAS: 55-63-0), its 96-hour LC50 for fish (bluegills) is 1.38 mg/L (Hazard Data Book for Chemical Substance (CERI), 2002) and it is classified into Category 2. Regarding nitrocellulose (CAS: 9004-70-0), its 96-hour EC50 for algae (Selenastrum) is 579000 microg/L (AQUIRE, 2003) and it is classified into the "Not classified" category. Regarding isopropyl alcohol (CAS: 67-63-0), its 96-hour LC50 for fish (himedaka) is > 100 mg/L (Test for the Ecological Effect of Chemical Substances (Ministry of the Environment), 1997) and it is classified into the "Not classified" category. Since this compound is composed of 60% nitroglycerin, 23% nitrocellulose, and 17% isopropyl alcohol, it was classified into Category 2. |
11 | Hazardous to the aquatic environment (Long-term) | Category 2 | - | H411: Toxic to aquatic life with long lasting effects |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Regarding nitroglycerin (CAS: 55-63-0), its classification for acute toxicity is Category 2 and its potential for bioaccumulation is presumably low (log Kow = 1.62 (PHYSPROP Database, 2005) and it is estimated not to be rapidly degradable (BIOWIN). Based on this information nitroglycerin is classified into Category 2. Regarding nitrocellulose (CAS: 9004-70-0), it is water soluble (water solubility: 1.00*10^6 mg/L (PHYSPROP Database, 2005)) and its acute toxicity is low. Thus, nitrocellulose is classified into the "Not classified" category. Regarding isopropyl alcohol (CAS: 67-63-0), it is water soluble (water solubility: 1.00*10^6 mg/L (PHYSPROP Database, 2005)) and its acute toxicity is low. Thus, isopropyl alcohol is classified into the "Not classified" category. Since this compound is composed of 60% nitroglycerin, 23% nitrocellulose, and 17% isopropyl alcohol, it was classified into Category 2. |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference Manual |
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