GHS Classification Result （Revision of the past classification result）

Chemical Name：Poly(oxyethylene) nonylphenyl ether
CAS：9016-45-9

Result：
ID: 494
Classifier: Ministry of Economy, Trade and Industry （METI）
Year Classified: FY2007
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives - - - - - -
2 Flammable gases （including chemically unstable gases） - - - - - -
3 Aerosols - - - - - -
4 Oxidizing gases - - - - - -
5 Gases under pressure - - - - - -
6 Flammable liquids - - - - - -
7 Flammable solids - - - - - -
8 Self-reactive substances and mixtures - - - - - -
9 Pyrophoric liquids - - - - - -
10 Pyrophoric solids - - - - - -
11 Self-heating substances and mixtures - - - - - -
12 Substances and mixtures which, in contact with water, emit flammable gases - - - - - -
13 Oxidizing liquids - - - - - -
14 Oxidizing solids - - - - - -
15 Organic peroxides - - - - - -
16 Corrosive to metals - - - - - -

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） - - - - - -
1 Acute toxicity （Dermal） - - - - - -
1 Acute toxicity （Inhalation: Gases） - - - - - -
1 Acute toxicity （Inhalation: Vapours） - - - - - -
1 Acute toxicity （Inhalation: Dusts and mists） - - - - - -
2 Skin corrosion/irritation - - - - - -
3 Serious eye damage/eye irritation - - - - - -
4 Respiratory sensitization - - - - - -
4 Skin sensitization - - - - - -
5 Germ cell mutagenicity - - - - - -
6 Carcinogenicity - - - - - -
7 Reproductive toxicity - - - - - -
8 Specific target organ toxicity - Single exposure - - - - - -
9 Specific target organ toxicity - Repeated exposure Category 2 (cardiovascular system) Warning H373: May cause damage to organs through prolonged or repeated exposure (cardiovascular system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		According to the Initial Risk Assessment No.96 (2005), "an increase in relative liver weight in female rats and, in the histopathological examination, fatty change in hepatic cell in male and female rats" were observed at 250 mg/kg/day or more in 90-day oral study in rats. However, 250 mg/kg/day is not within the limits of the guidance value of "Category 2." Therefore, liver is not included in the specific target organ for repeated exposure. Moreover, according to the paper by Smyth and Calandra (1969), focal necrosis of heart muscle was observed not only in the dogs but in the guinea pig as well. In the NPE20 oral administration study using dogs, focal myocardial necrosis is observed in the group receiving 0.20g/kg/day (34-day administration) and the group receiving 0.04g/kg/day (90-day administration), and both doses are within the guidance value ranges of "Category 2" after conversion during the dosing period. In the public comments, it is pointed out that GHS classification should be considered by dividing the substance into E.O. add. mols, but there is no limit to E.O. add. mols determined for this substance, "poly (oxypropylene) = nonylphenyl ether" and classification for the most hazardous substance must be adopted. Therefore, since focal myocardial necrosis is observed within the guidance value ranges equivalent to "Category 2" in the NPE20 oral administration study using dogs, it is considered proper to be defined as "Category 2 (cardiovascular system)", if based on GHS classification.
10 Aspiration hazard - - - - - -

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） - - - - - -
11 Hazardous to the aquatic environment （Long-term） - - - - - -


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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