GHS Classification Result (Revision of the past classification result)

Chemical Name:2-Propenenitrile, 2-methyl-
CAS:126-98-7

Result:
ID: 205
Classifier: Ministry of Economy, Trade and Industry (METI)
Year Classified: FY2007
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives - - - - - -
2 Flammable gases (including chemically unstable gases) - - - - - -
3 Aerosols - - - - - -
4 Oxidizing gases - - - - - -
5 Gases under pressure - - - - - -
6 Flammable liquids - - - - - -
7 Flammable solids - - - - - -
8 Self-reactive substances and mixtures - - - - - -
9 Pyrophoric liquids - - - - - -
10 Pyrophoric solids - - - - - -
11 Self-heating substances and mixtures - - - - - -
12 Substances and mixtures which, in contact with water, emit flammable gases - - - - - -
13 Oxidizing liquids - - - - - -
14 Oxidizing solids - - - - - -
15 Organic peroxides - - - - - -
16 Corrosive to metals - - - - - -

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) - - - - - -
1 Acute toxicity (Dermal) - - - - - -
1 Acute toxicity (Inhalation: Gases) - - - - - -
1 Acute toxicity (Inhalation: Vapours) - - - - - -
1 Acute toxicity (Inhalation: Dusts and mists) - - - - - -
2 Skin corrosion/irritation - - - - - -
3 Serious eye damage/eye irritation - - - - - -
4 Respiratory sensitization - - - - - -
4 Skin sensitization - - - - - -
5 Germ cell mutagenicity - - - - - -
6 Carcinogenicity - - - - - -
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Thorough review of original documents was made regarding significant decrease of the number of sperms in males of F 1 generation and delay of estrous cycles in females that became the base of 3-Ministry GHS Classification in the second generation growth study, and effects of reproductive toxicities identified have all been of low level as the result. Therefore, it will be more appropriate to classify it in "Category 2" than classifing in "Category 1"on the assumption that there are effects on humans.
8 Specific target organ toxicity - Single exposure - - - - - -
9 Specific target organ toxicity - Repeated exposure Category 1 (central nervous system), Category 2 (blood system, nasal cavity [olfactory epithelia], liver) Danger
Warning
H372: Cause damage to organs through prolonged or repeated exposure (central nervous system)
H373: May cause damage to organs through prolonged or repeated exposure (blood system, nasal cavity [olfactory epithelia], liver)
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
In the public comments it is pointed out that the observed neurotoxicity is acute toxicity rather than chronic toxicity. However, in a 90-day oral toxicity test in dogs in the work of Pozzani et al (1968), tonic convulsions, pulsus celer, polypnea and hind limb acratia were not observed immediately after exposure at doses within the range of guidance values for Category 1 (13.5 ppm group), but were observed from the 39th day of exposure. Therefore, it can be said that the symptoms in the central nervous system in this study are caused by repeated exposure. Moreover, in the public comments it is pointed out that there are no effects which apply to classification standards for toxicity, except for neurotoxicity.
10 Aspiration hazard - - - - - -

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) - - - - - -
11 Hazardous to the aquatic environment (Long-term) - - - - - -


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model SDS by MHLW

MHLW Website (in Japanese Only)


To GHS Information