GHS Classification Result （Revision of the past classification result）
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Di-n-butyl phthalate
CAS：84-74-2
Result：
| ID: | 182 |
| Classifier: | Ministry of Economy, Trade and Industry （METI） |
| Year Classified: | FY2007 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | - | - | - | - | - | - |
| 2 | Flammable gases （including chemically unstable gases） | - | - | - | - | - | - |
| 3 | Aerosols | - | - | - | - | - | - |
| 4 | Oxidizing gases | - | - | - | - | - | - |
| 5 | Gases under pressure | - | - | - | - | - | - |
| 6 | Flammable liquids | - | - | - | - | - | - |
| 7 | Flammable solids | - | - | - | - | - | - |
| 8 | Self-reactive substances and mixtures | - | - | - | - | - | - |
| 9 | Pyrophoric liquids | - | - | - | - | - | - |
| 10 | Pyrophoric solids | - | - | - | - | - | - |
| 11 | Self-heating substances and mixtures | - | - | - | - | - | - |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | - | - | - | - | - | - |
| 13 | Oxidizing liquids | - | - | - | - | - | - |
| 14 | Oxidizing solids | - | - | - | - | - | - |
| 15 | Organic peroxides | - | - | - | - | - | - |
| 16 | Corrosive to metals | - | - | - | - | - | - |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Not classified | - | - | - | - | The primary literature in which the human information currently referred in the three-ministry GHS classification is indicated was scrutinized. Although corneal damages and kidney effects are found in the accidental ingestion case of human (23 years-old male drank 10g by mistake) it is judged to be a mild condition from a clinical view hematology and urinalysis a medical treatment situation and the like. Therefore this symptom could not be judged to be significant toxic effect and application of this human case to the classification was judged to be unsuitable. Therefore rat LD50 value of 6300 mg/kg (EU-RAR (vol.29 2004)) was adopted to correct from "Category 5" to "Not classified". |
| 1 | Acute toxicity （Dermal） | - | - | - | - | - | - |
| 1 | Acute toxicity （Inhalation: Gases） | - | - | - | - | - | - |
| 1 | Acute toxicity （Inhalation: Vapours） | - | - | - | - | - | - |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | - | - | - | - | - | - |
| 2 | Skin corrosion/irritation | Not classified | - | - | - | - | Addendum of European Union-RAR (2004) were absent from the investigation subject of substance data. Although a description of skin irritation has been shown in CERI/NITE Hazard Assessment Report No.11 (2004) and EU-RAR No.29 (2003), it was modified to "Not classified" because of descriptions of the result of no irritation in the test based on OECD TG404 and no irritation as a conclusion in the addendum European Union-RAR (2004) (addendum to the Environmental section) of EU-RAR No.29 (2003). |
| 3 | Serious eye damage/eye irritation | Not classified | - | - | - | - | The addendum of uropean Union-RAR (2004) was absent from the investigation subject of substance data. Although CERI/NITE Hazard Assessment Report No.11 (2004) and EU-RAR No.29 (2003) have a statement that eye irritation was observed and was recovered in 48 or 72 hours, in the addenda of EU-RAR No.29 (2003), EU-RAR (2004) (addendum to the Environmental section), the result of "not irritating" was indicated in the study based on OECD TG405, and the addenda, EU-RAR (2004), concluded the result as "not irritating". Therefore, it was corrected to "Not classified". |
| 4 | Respiratory sensitization | - | - | - | - | - | - |
| 4 | Skin sensitization | - | - | - | - | - | - |
| 5 | Germ cell mutagenicity | - | - | - | - | - | - |
| 6 | Carcinogenicity | - | - | - | - | - | - |
| 7 | Reproductive toxicity | - | - | - | - | - | - |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (kidney), Category 3 (respiratory tract irritation) |
|
Danger Warning |
H370: Causes damage to organs (kidney) H335: May cause respiratory irritation (respiratory tract irritation) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. |
The classification of Category 1 (kidney) is judged to be appropriate from human cases. Moreover, a nervous system is the condition at the exposure concentration exceeding the guidance value of Category 2, and is unsuitable for classification. Therefore, Category 1 (nervous system) was not covered. |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (upper respiratory), Category 2 (liver) |
|
Danger Warning |
H372: Cause damage to organs through prolonged or repeated exposure (upper respiratory) H373: May cause damage to organs through prolonged or repeated exposure (liver) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
According to GHS United Nations documents, the negative effects on the reproductive functions of adult males and females are included in reproductive toxicity, and this substance is classified as Category 2 on the basis that a decrease in sperm production capacity was observed. It is appropriate to delete the testis from the target organs, because the fact that with repeated exposure there are negative effects on male reproductive functions, already included under reproductive toxicity, would end up being covered twice, and it does not match the GHS definition. Moreover, in inhalation exposure test using rats, not only dosage dependent mucilage cell hyperplasia in the nasal cavity but also dosage dependent squamous metaplasia in the larynx are observed. Considering all of the above, it is proper to classify it as "Category 1 (upper respiratory organs)", since it can be judged that it has adverse effects on upper respiratory organs and these effects are recognized within the guidance value ranges of Category 1. From the above, the result of GHS classification is changed to "Category 1 (upper respiratory organs) and Category 2 (liver)." |
| 10 | Aspiration hazard | - | - | - | - | - | - |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | - | - | - | - | - | - |
| 11 | Hazardous to the aquatic environment （Long-term） | - | - | - | - | - | - |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |