GHS Classification Result （Revision of the past classification result）

Chemical Name：p-Dichlorobenzene
CAS：106-46-7

Result：
ID: 140
Classifier: Ministry of Economy, Trade and Industry （METI）
Year Classified: FY2007
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives - - - - - -
2 Flammable gases （including chemically unstable gases） - - - - - -
3 Aerosols - - - - - -
4 Oxidizing gases - - - - - -
5 Gases under pressure - - - - - -
6 Flammable liquids - - - - - -
7 Flammable solids - - - - - -
8 Self-reactive substances and mixtures - - - - - -
9 Pyrophoric liquids - - - - - -
10 Pyrophoric solids - - - - - -
11 Self-heating substances and mixtures - - - - - -
12 Substances and mixtures which, in contact with water, emit flammable gases - - - - - -
13 Oxidizing liquids - - - - - -
14 Oxidizing solids - - - - - -
15 Organic peroxides - - - - - -
16 Corrosive to metals - - - - - -

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） - - - - - -
1 Acute toxicity （Dermal） - - - - - -
1 Acute toxicity （Inhalation: Gases） - - - - - -
1 Acute toxicity （Inhalation: Vapours） - - - - - -
1 Acute toxicity （Inhalation: Dusts and mists） - - - - - -
2 Skin corrosion/irritation - - - - - -
3 Serious eye damage/eye irritation - - - - - -
4 Respiratory sensitization - - - - - -
4 Skin sensitization - - - - - -
5 Germ cell mutagenicity Not classified - - - - A negative result exists in a heritable mutagenicity test. Four cases among six cases are negative for in vivo micronucleus test shown in EU RAR No.48 (2004). Two of them are the results in micronucleus test performed by NTP in 13-weeks test for two year carcinogenicityity test dose level setting and in the micronucleus test of Morita (1997) carried out as the 6th collaborative research by CSGMT/JEMS.MMS, and they are all reliable. One result among two cases of in vivo micronucleus test positivity results which are the classification basis of "Category 2" in the three-ministry GHS classification was negative in the supplementary examination by another researcher. The other is a combined test with Comet Test using rat kidneys treated with folic acid injection other than the test substance, and it cannot be said to be proper. Therefore, the public comments which claimed that the positive test results were lacking reliability can be said to be proper. Considering all the above results, "Category 2" will be corrected to "Not classified".
6 Carcinogenicity - - - - - -
7 Reproductive toxicity - - - - - -
8 Specific target organ toxicity - Single exposure - - - - - -
9 Specific target organ toxicity - Repeated exposure - - - - - -
10 Aspiration hazard - - - - - -

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） - - - - - -
11 Hazardous to the aquatic environment （Long-term） - - - - - -


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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