GHS Classification Result （Revision of the past classification result）

Chemical Name：Divanadium pentaoxide
CAS：1314-62-1

Result：
ID: 26
Classifier: Ministry of Economy, Trade and Industry （METI）
Year Classified: FY2007
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives - - - - - -
2 Flammable gases （including chemically unstable gases） - - - - - -
3 Aerosols - - - - - -
4 Oxidizing gases - - - - - -
5 Gases under pressure - - - - - -
6 Flammable liquids - - - - - -
7 Flammable solids - - - - - -
8 Self-reactive substances and mixtures - - - - - -
9 Pyrophoric liquids - - - - - -
10 Pyrophoric solids - - - - - -
11 Self-heating substances and mixtures - - - - - -
12 Substances and mixtures which, in contact with water, emit flammable gases - - - - - -
13 Oxidizing liquids - - - - - -
14 Oxidizing solids - - - - - -
15 Organic peroxides - - - - - -
16 Corrosive to metals - - - - - -

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） - - - - - -
1 Acute toxicity （Dermal） - - - - - -
1 Acute toxicity （Inhalation: Gases） - - - - - -
1 Acute toxicity （Inhalation: Vapours） - - - - - -
1 Acute toxicity （Inhalation: Dusts and mists） - - - - - -
2 Skin corrosion/irritation - - - - - -
3 Serious eye damage/eye irritation - - - - - -
4 Respiratory sensitization - - - - - -
4 Skin sensitization - - - - - -
5 Germ cell mutagenicity - - - - - -
6 Carcinogenicity - - - - - -
7 Reproductive toxicity Classification not possible - - - - CICAD 29 (2001) that is the evidential document for 3-Minisrty GHS Classification was thoroughly reviewed and it is considered inappropriate to cite from the experiment relating to reproductive capabilities, because this experiment, among the experiments used as evidence, was executed with Sodium metavanadate, not with Vanadium (V)oxide as the public comment pointed out. In addition, with regard to the experiment that used Vanadium (V)oxide and whose effect on fetuses was identified it is considered inappropriate to make judgements based on the result of this experiment, because absence of the datum per each litter makes data analysis inappropriate and causes problems to the reliability in making decisions, as mentioned in CICAD. Therefore, GHS Classification needs to be changed from "Category 2" to "Classification not possible."
8 Specific target organ toxicity - Single exposure Category 1 (respiratory system, liver, kidney) Danger H370: Causes damage to organs (respiratory system, liver, kidney) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Although public comments indicated that it cannot go back to the original report of the quotation reference of a three-ministry GHS classification, going back to original report is possible. When each document was checked, we found a description on respiratory systems that bronchitis and bronchopneumonia lesions are acknowledged within the limits of guidance value of "Category 1" in the single inhalation exposure test employing rabbits written in the literature of Sjoberg and others (1950), therefore, the GHS classification is appropriate to be "Category 1." Moreover, referring to Duthon (1911), the primary literature of the description of "anemia and increasing leukocytes", the description on the blood system is about patients with repeated exposure, who are likely to have been exposed to vanadium compounds other than Vanadium (V) oxide. Therefore, this literature is not adopted and the blood system is excluded from the specific target organs. As for the effects on liver and kidney, according to CICAD, hepatocellular necrosis and opacity expansion of kidney tubulars are observed in the rat study where LD50 value is within the guidance value ranges of "Category 1". Therefore, "Category 1 (liver, kidney)" is considered to be proper. Based on the above, "Category 1 (respiratory organs, blood system, liver, kidney)" is corrected to "Category 1 (respiratory system, liver, kidney)
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory system), Category 2 (liver) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (respiratory system)
H373: May cause damage to organs through prolonged or repeated exposure (liver) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Although in the public comments it is pointed out that they could not revert back to the original report cited in the Tri-Ministry GHS classification's references, reverting back to the original report is possible. Moreover, although they pointed out in the public comments that from the weight of evidence it is appropriate to adopt CICAD, according to GHS United Nations documents, even when data is not cited in documents highly regarded by experts, it is possible to use it for GHS classifications. As for the respiratory system, in ACGIH the TLV-TWA is set while taking respiratory effects into consideration, and in CICAD Respiratory tract irritation is given as a toxicological endpoint. Moreover, according to the data of Roshchin (1952) in ACGIH, nasal discharges including bleeding and focal lung edema are observed within the guidance value ranges of "Category 1" in the inhalation exposure test using rats. Therefore, it is considered proper to be classified as "Category 1 (respiratory system)". Referring to Sjoberg (1955), the primary literature of human data, which is also a rationale for three-ministry GHS classification, about effects on blood system and nervous system, it is concluded that "no general toxicity which should be noted is observed" though decreasing tendency in hemoglobin and significant fatigue symptoms are found in several patients. Therefore, it is not appropriate to regard blood system and nervous system as specific target organs for repeated exposure based on this literature. Referring to Handbook of the Toxicology of Metals. 2nd ed. (1986)for effects on the liver, fatty degeneration accompanied by focal hepatocellular necrosis is observed within the guidance value ranges of " Category 2" in the inhalation exposure test using rats. Therefore, "Category 2 (liver)" is considered poper in GHS classification. In addition, although the public comments have indicated that Vanadium are widely present in the nature and it is also taken from foods, it is not necessary to take the exposure into account in GHS classification, if based on UN documents on GHS. Based on the above, "Category 1 (respiratory organs, blood system, nervous system, liver)" was corrected to "Category 1 (respiratory system) and "Category 2 (liver)".
10 Aspiration hazard - - - - - -

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） - - - - - -
11 Hazardous to the aquatic environment （Long-term） - - - - - -


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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