GHS Classification Result

Chemical Name：N-methylformamide
CAS：123-39-7

Result：
ID: 18
Classifier: Ministry of Economy, Trade and Industry （METI）
Year Classified: FY2007
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives - - - - - -
2 Flammable gases （including chemically unstable gases） - - - - - -
3 Aerosols - - - - - -
4 Oxidizing gases - - - - - -
5 Gases under pressure - - - - - -
6 Flammable liquids - - - - - -
7 Flammable solids - - - - - -
8 Self-reactive substances and mixtures - - - - - -
9 Pyrophoric liquids - - - - - -
10 Pyrophoric solids - - - - - -
11 Self-heating substances and mixtures - - - - - -
12 Substances and mixtures which, in contact with water, emit flammable gases - - - - - -
13 Oxidizing liquids - - - - - -
14 Oxidizing solids - - - - - -
15 Organic peroxides - - - - - -
16 Corrosive to metals - - - - - -

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 5 - Warning H303: May be harmful if swallowed P312: Call a POISON CENTER or doctor/physician if you feel unwell. Based on 4,000 mg/kg of LD50 value of a rat (HSDB (2002)), it is classified into Category 5.
1 Acute toxicity （Dermal） Category 4 Warning H312: Harmful in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Based on LD50 value 2,000 mg/kg of rabbit indicated in GESTIS (Access on Feb.2008) of Priority 3, it is classified into Category 4. In addition, EU Annex I is Xn; R21 and is equivalent to the GHS Category 3-4.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Since it was a liquid by the definition of GHS, it was classified into "Not applicable".
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Saturated vapor pressure level at 20degCis 223 ppm. It is written in GESTIS (Access on Feb.2008) of Priority 3 that there was no mortality and no clinical symptom in case that rats were exposed in the saturated steam at 20degC for 7 hours (4-hour equivalent 0.71 mg/L). Since the vapor standard value of Category 2 is 2.0 mg/L, classification is not possible.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Saturated vapor pressure level at 20degCis 223 ppm. It is written in GESTIS (Access on Feb.2008) of Priority 3 that there was no mortality and no clinical symptom in case those rats were exposed to 4.02 mg/L for 4 hours. The mist and dust standard value of Category 4 is 5 mg/L, and classification is not possible.
2 Skin corrosion/irritation Classification not possible - - - - Although there is a description in GESTIS (Access on FEB.2008) of Priority 3, "Although this is a judgement of the experimental results with 1 animal, the possibility of skin irritation can probably be ignored, "classification is not possible, because concrete data are unknown.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		Based on the statement of the "eye irritation" of ICSC (2001) and HSDB (2002), and the statement of HSDB (2002) of "the onset of conjunctivitis is indicated and the effect is mild in animals studies," it is classified into Category 2B. In addition, GESTIS (Access on Feb.2008) of Priority 3 indicates as "Since the test result to eyes of rabbits varies, it is necessary to take into consideration the reversible damage at the time of contacting human's eyes directly".
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Classification not possible - - - - Although it has been described in GESTIS of Priority (Access on Feb.2008) that "the potential to cause sensitization was not indicated although the dehydration action and the action inhibiting the protection function of skin had to be predicted in long time contact like Dimethylformamide," it is classified into "Classification not possible" because of no data of concrete epidemiologic survey, case report, and animal experiment.
5 Germ cell mutagenicity Classification not possible - - - - According to NTP (Access on Feb.2008), it is negative in the in vitro mutagenicity test (reverse mutation test employing bacterial cells), the data of the in vivo examination is not indicated. On the other hand, GESTIS of Priority 3 (Access on Feb.2008) describes "The potential mutagen could not be identified in the reverse mutation test of narrow species and the in vivo heritable mutagenic test (dominant lethal test) employing a productive cell." Since the data of in vivo studies is not indicated in the information source of Priority 1 and 2, and details on the dominant lethal tests in GESTIS (Access on Feb.2008) are unknown, classification is not possible.
6 Carcinogenicity Classification not possible - - - - Since there is no evaluation by international reputations institutions and there is also no data, classification is not possible.
7 Reproductive toxicity Category 1B Danger H360: May damage fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		There is a description as follows in HSDB (2002), "With dermal administration to female rats of 7-14 day prgnancy 87% of fetuses died and deformation (hydronephrosis, hydrocephalus) was caused to all live fetuses and similar results were obtained via the oral route. In the case of dermal route applied to pregnant rabbits during the formation period of fetal organs a low level of teratogenicity was observed." When content of the primary document of HSDB was closely reviewed, the effect found in pregnant rats within the range of dose concentrations was that causing the body weight reduction (7-9%). Effects on rabbits are not known because their body weight was not measured. Since fetal death and teratogenicity were found with rats after all at the concentration level where almost no maternal toxicity exsisted, it was classified into Category 1B. EU Annex 1, however, corresponds to Cat.2, R61, corresponding to GHS Category 1B.
8 Specific target organ toxicity - Single exposure Category 1 (liver, systemic symptom) Danger H370: Causes damage to organs (liver, systemic symptom) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Although ICSC (2001) of Priority 2 has a description of "cough", it dose not mention any irritation other than eye irritation in the paragraph of short term exposure. Moreover, to GESTIS of Priority 3 (Access on Feb.2008) has a description that "there is oral administration data solely as a cancer drug, and nausea, vomiting, and an impaired liver function were seen by the concentration beyond 15 mg/kg which is not so high" on humans. Although human data is based on the information source of Priority 2,3, since it can be predicted that there is abundance of clinical cases as clinical drugs, it is defined as Category 1 (liver, systemic symptoms, respiratory system).
9 Specific target organ toxicity - Repeated exposure Category 1 (liver, systemic symptom, respiratory system) Danger H372: Cause damage to organs through prolonged or repeated exposure (liver, systemic symptom, respiratory system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Short term exposure has effects on liver (ICSC (2001)). As for human, HSDB (2002) shows that "the patients who were administered the substance as an oral cancer drug experienced nausea, vomiting and poor appetite, and those who were administered a total of 80 mg/kg or more were found to have damage in the liver in the liver function test" and there is the description in the Priority 3 of GESTIS that "although most human exposure information is based on the oral administration as cancer drugs, a short-term exposure to much smaller concentrations causes remarkable disorder in respiratory function." Since the check of the primary literature of GESTIS is difficult, the specific period is unknown. Although human data is based on the information source of Priority 2,3, since it can be predicted that there is abundance of clinical cases as clinical drugs, it is defined as Category 1 (liver, systemic symptoms, respiratory system).
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） - - - - - -
11 Hazardous to the aquatic environment （Long-term） - - - - - -


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations

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