GHS Classification Result

Chemical Name：2-methyl-m-phenylene diamine
CAS：823-40-5

Result：
ID: 13
Classifier: Ministry of Economy, Trade and Industry （METI）
Year Classified: FY2007
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives - - - - - -
2 Flammable gases （including chemically unstable gases） - - - - - -
3 Aerosols - - - - - -
4 Oxidizing gases - - - - - -
5 Gases under pressure - - - - - -
6 Flammable liquids - - - - - -
7 Flammable solids - - - - - -
8 Self-reactive substances and mixtures - - - - - -
9 Pyrophoric liquids - - - - - -
10 Pyrophoric solids - - - - - -
11 Self-heating substances and mixtures - - - - - -
12 Substances and mixtures which, in contact with water, emit flammable gases - - - - - -
13 Oxidizing liquids - - - - - -
14 Oxidizing solids - - - - - -
15 Organic peroxides - - - - - -
16 Corrosive to metals - - - - - -

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Classification not possible - - - - Classification is not possible because there is no data. In addition, 2,5-TDA, and 2,4-TDA are equivalent to Category 3. [NOTE] See the classification results of 2,4-TDA (2,4-toluene diamine, ID167, CAS: 95-80-7), 2,5-TDA (paratoluylenediamime, ID1324, CAS: 95-70-5)), TDA (Toluylenediamine, ID1309, CAS: 25376-45-8) which is a collective term for TDA constitutional isomer. For this harmful effect for the health, the classification result of these isomers is indicated as needed.
1 Acute toxicity （Dermal） Classification not possible - - - - Classification is not possible because there is no data. In addition, 2,5-TDA cannot be classified, and 2,4-TDA is Category 3.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Since it was a solid by the definition of GHS, it was classified into "Not applicable".
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Classification not possible due to lack of data
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		Although there is no skin irritation test data of this substance, it has been described that this substance has a "skin irritation" in ICSC (2001) or that "Diaminotoluene irritates skin" in EHC 74 (1987). It may be classified as Category 2 or Category 3 since it is likely to have an irritation despite its unknown degree. It is classified into Category 2 from a viewpoint of safety. In addition, 2,5-TDA and 2,4-TDA can be classified as Category 3.
3 Serious eye damage/eye irritation Category 2 Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Although there is no data of the eye irritation test of this substance, it has been described that the substance is "eye-irritative" in ICSC (2001), or that "Diaminotoluene irritates eyes" in EHC 74 (1987). Although the level is unknown, since it is considered to own irritation, it is classified into Category 2. In addition, 2,5-TDA is Category 2A-2B and 2,4-TDA are Category 2A.
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Classification not possible - - - - It can be classified as R43 in EU-Annex I which is the source of information of Priority2, and it has been described in ICSC (2001) which is the source of information of Priority2 in the same way that skin may be sensitized by the repeated or long-term contact." However, it was classified into "Classification not possible" because of no data of concrete epidemiologic survey, case report, and animal experiment. In addition, 2,5-TDA, 2,4-TDA, and TDA are Category 1.
5 Germ cell mutagenicity Not classified - - - - Although there are very weak positive findings (Carcinogenesis, 12, 2233-2237, 1991) in rat bone marrow micronucleus tests as a result of investigation not only on the information source of Priority 1, 2, it was defined as "Not classified" from the weight of the evidence based on two negative findings in the mutation assays employing transgenic mice (Environ Health Perspect, 104 (Suppl 3), 683-686, 1996; Mutat Res, 608,88-96, 2006) and the negative results in rat liver UDS tests (Carcinogenesis,12, 2233-2237,1991). Moreover, although 2,4-TDA is defined as "Not classified" as a result of the previous classification, a positive result has been obtained in the above mutation assays employing transgenic mice, and it is classified into Category 2.
6 Carcinogenicity Not classified - - - - There is no existing classification. On the other hand, EHC 74 (1987) cited the 103-week oral administration test employing rats and mice by NCI (1980). EHC is saying that "NCI (1980) concluded that 2,6-TDA does not show carcinogenicityity to F344 rat of male and female, and B6C3F1 mouse of male and female" based on various statistical evaluations, and the reliability of the data of NCI can be evaluated. Therefore, the conclusion of NCI was adopted and it was carries out "Not classified". In addition, in a three-ministry GHS classification, 2,5-TDA is "Not classified", 2,4-TDA and TDA are in Category 2.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since embryonic death has been identified at the dose level where decrease in the body weight of mother animals is identified in the oral administration study using rabbits in the description of EHC 74 (1987), it is classified in Category 2. In addition, since increase of imperfect spinal segments development in fetuses at the dose level where the body weight reduction of mother animals is not identified is identified in the oral administration study using rats published in EHC 74 (1987), which corresponds to a skeletal variant, GHS is considered to correspond to Category 2. Moreover, strenebrae deficiencies and imperfect closure of skulls have been observed at the dose level where the body weight reduction in mother animals is observed. 2.5-TDA, 2.4-TDA and TDA are all Category 2.
8 Specific target organ toxicity - Single exposure Category 2 (blood system), Category 3 (respiratory tract irritation, narcotic effects) Warning H371: May cause damage to organs (blood system)
H336: May cause drowsiness or dizziness (respiratory tract irritation, narcotic effects)
H335: May cause respiratory irritation (respiratory tract irritation, narcotic effects) 		P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		About humans, ICSC (J) (2001) which is the information source of Priority2, have descriptions of "cough, dizziness, headache, shortness of breath, confusion, spasm, nausea, and deliquium animi" as acute symptoms by inhalation exposures, and that "airway is stimulated. Blood may be affected and a methemoglobin may be generated" as effects of short durations exposures. Therefore, it was considered to have Respiratory tract irritation and Narcotic effects, and its target organ was the blood systems. As mentioned above, the category was taken as Category 2 (blood system) and Category 3 (Respiratory tract irritation, Narcotic effects).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Classification is not possible because there is no data. In addition, 2,5-TDA cannot be classified, and 2,4-TDA is classified as Category 1 (liver, kidney), Category 2 (blood system, lien, testis). TDA is classified as Category 1 (liver).
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） - - - - - -
11 Hazardous to the aquatic environment （Long-term） - - - - - -


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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