GHS Classification Result

Chemical Name：pyrogallol
CAS：87-66-1

Result：
ID: 11
Classifier: Ministry of Economy, Trade and Industry （METI）
Year Classified: FY2007
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives - - - - - -
2 Flammable gases （including chemically unstable gases） - - - - - -
3 Aerosols - - - - - -
4 Oxidizing gases - - - - - -
5 Gases under pressure - - - - - -
6 Flammable liquids - - - - - -
7 Flammable solids - - - - - -
8 Self-reactive substances and mixtures - - - - - -
9 Pyrophoric liquids - - - - - -
10 Pyrophoric solids - - - - - -
11 Self-heating substances and mixtures - - - - - -
12 Substances and mixtures which, in contact with water, emit flammable gases - - - - - -
13 Oxidizing liquids - - - - - -
14 Oxidizing solids - - - - - -
15 Organic peroxides - - - - - -
16 Corrosive to metals - - - - - -

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		As LD50 value of a rat, there is an example (female: 800 mg/kg and male: 1,270 mg/kg) in HSDB (2003), and there is a 790 mg/kg example in RTECS (1997). By comparison of former female 800 mg/kg and latter 790 mg/kg, it is classified into Category 4 based on the lower value of 790 mg/kg. In addition, EU Annex I is R22 and is equivalent to the GHS Category 3 to 4.
1 Acute toxicity （Dermal） Category 5 - Warning H313: May be harmful in contact with skin P312: Call a POISON CENTER or doctor/physician if you feel unwell. Although HSDB (2003) has described the rat LD50 value is >2,100 mg/kg, since one rat of 12 rats has deceased at amount of application of 2,100 mg/kg, it is classified into Category 5. In addition, EU Annex I is R21 and is equivalent to the GHS Category 3-4.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Since it was a solid by the definition of GHS, it was classified into "Not applicable".
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Classification is not possible because there is no data. In addition, EU Annex I is Xn; R20/21/22, and is equivalent to the GHS Category 3-4.
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. It was classified in the Category 3. because ICSC (2006) states, "mild irritation. "Incidentally, HSDB describes that 24 hour applications of the industrial product and the natural substance to guinea pig caused erythema in 4/6 and 3/6 animals respectively but they disappeared in 72 hours. Moreover, the "severe irritation" described in RTECS is the result of such a long time application as 24 hour application to rabbits.
3 Serious eye damage/eye irritation Category 2 Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		There are descriptions of "moderate irritation" in RTECS (1997), of "slight reaction, score 7-10 (maximum value: 100" in HSDB (2003), and of "irritation" in ICSC (2006), in the test employing rabbits. Although it was considered Category 2A or Category 2B from these descriptions, since it is inadequate as a basis of fine classification, it is classified into Category 2.
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Classification not possible - - - - Although it has been described that "sensitizing potential may be developed by the repeated contact to skin" in ICSC (2006) and HSDB (2003), it was classified into "Classification not possible" because of no data of concrete epidemiologic survey, case report, and animal experiment.
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Although there is positive finding in vivo mutagenicity test (micronucleus test employing the mouse bone marrow cell) which employed the somatic cell in the original literature (Mutation Research, 90, 91 (1981)) which HSDB (2003) has quoted, since there is no positive finding of in vivo genotoxicity testgenotoxicity test using a germ cell, it is classified into Category 2. In addition, HSDB (2003) has positive results , in some of which reliability is not evaluated yet, in two or more in vitro mutagenicity tests (the chromosome aberration of human lymphocytes, the gene mutations of mouse lymphoma cells, and Ames), it is defined as Category 2 in ICSC (2006) where genetic disorder is suspected. Moreover, EU Annex I is Muta.Cat.3; R68 and is equivalent to the GHS Category 2. Isomer, 1,3,5-trihydroxybenzene is positive in in vitro chromosome aberration test using CHL/IU cells and negative in Ames tests.
6 Carcinogenicity Classification not possible - - - - Classification not possible due to lack of data
7 Reproductive toxicity Classification not possible - - - - When the primary document(Picciano and others, Journal of the American College of Toxicology, 1983) describing "Effects on the post implantation death rate and resorption and fetal toxicity in the oral administration study with rats"in RTECS(1997) was reviewed, there were descriptions as follows, "At the dose level where toxicity causing nothing else other than suppression of body weight increase among parent animals reduction of the number of children and deformation of organ and skelton were not found, even though body weight reduction was observed among children," and the document conclued as follows, "There is no teratogenicity."Since increase of resorption is found, however, at the dose level of 300mg/kg as described in RTECS, the study contents are hard to be considered to expressly deny the reproductive toxicity of this substance. Moreover, since increase of this resorption was also found when Propylene glycol alone was administered, the study results cannot deny the effect of Propylene glycol. Since there is no information other than this report in Priority 1 and 2, it was classified into "Classification not possible".
8 Specific target organ toxicity - Single exposure Category 2 (digestive system, kidney, liver, blood system, central nervous system, circulatory system), Category 3 (respiratory tract irritation) Warning H371: May cause damage to organs (digestive system, kidney, liver, blood system, central nervous system, circulatory system)
H335: May cause respiratory irritation (respiratory tract irritation) 		P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		As for humans, HSDB (2003) of Priority2 indicated that it may cause gastrointestinal irritation, kidney and liver damage, hemolytic, convulsions and circulatory collapse, and ICSC (2006) has a description that "There is Respiratory tract irritation", therefore, it is classified into Category 2 (an digestive system, the kidney, liver, blood systems, a central nervous system, a circulatory system) and Category 3 (Respiratory tract irritation).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In Priority 2 in HSDB (2003), there are reports of symptoms of edema and hyperemia in the kidney, lungs and liver, as well as abnormalities of the heart, bone marrow and lien in animals, but when we checked the original articles' details, they all turned out to have been published between 1877 and 1908, so it was judged that the reports lacked credibility. Since there was no other data in Priority 1 and 2, it was classified into "Classification not possible" because of insufficient data.
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） - - - - - -
11 Hazardous to the aquatic environment （Long-term） - - - - - -


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations

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