Chemical Name：Alkanes, C10-13, chloro(shortchain chlorinated paraffins)
CAS：85535-84-8

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Not classified	-	-	-	-	In the oral administration test employing a rat, from the fact that there was no mortality at dose of 10,000 mg/kg (carbon number C10-13/chlorination rate (41- 50%, 51-60% or 61-70%)) and at dose of 13,600 mg/kg (carbon number C12/chlorination rate 60%) (EU-RAR (1999)), it was classified into "Not classified". In addition, EU-RAR (1999) indicates that the symptom and its extent are irrelevant to the chlorination rate.
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	It was classified into "Not classified" from LD50 value >13,500 mg/kg (number of carbon: C12 / rate of chlorination: 59%) (EU-RAR (1999)) of the dermal administration test employing a rabbit.
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Since it was a liquid by the definition of GHS, it was classified into "Not applicable".
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	Classification not possible due to lack of data
1	Acute toxicity （Inhalation: Dusts and mists）	Not classified	-	-	-	-	Since there was no mortality with dose 3.3 mg/L/1hr (4hr equivalent: 0.83 mg/L) (carbon number C12/ chloridization rate 59%), and there was no mortality with dose 48 mg/L/1hr (carbon number C10-C13/ chloridization rate 50%)in the inhalation administration test employing rats (EU-RAR (1999)), it was classified into "Not classified". Since saturation vapor pressure concentration was computed to be 0.000037-0.00014 mg/L from saturation vapor pressure 0.00014-0.00052 Pa (25degC) (rate of carbon number C12/chlorination, 59%) (Risk Assessment Documents vol. 5 (2005)), it was classified according to the coarse particulate and mist standard.
2	Skin corrosion/irritation	Not classified	-	-	-	-	There is an information that erythema and slight edema could be seen in rabbits but such symptoms disappeared (carbon number C10-13/chloridization rate 70%) within 7 days (EU-RAR (1999)). Since the score value in this datum for erythema of 2 out of 3 animals was 1 (maximum 4) and the score value for edema of 2 out of 3 animals was 1 (maximum 4 untill 24 hours after application), they do not correspond to GHS Category 3. There is an information about humans beside them that although slight erythema and dry skin were observed, the effect (carbon number C10-12/ chloridization rate 5-% 63%) was corresponding to that of the control group or there was no symptom (carbon number C12/chloridization rate 59%), and there is an information about rabbits that there is no irritation (carbon number C10-13/chloridization rate 59%) (EU-RAR (1999)). It was classified into "Not classified" based on the above-mentioned.
3	Serious eye damage/eye irritation	Category 2B	-	Warning	H320: Causes eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling.	Since EU-RAR (1999) has summarized that it is a mild irritation from the data of slight redness (59% of carbon number C12-/chlorination rate) and redness and conjunctiva dropsy being produced and continuing for 24 hours (carbon number: C10-13/chlorination rate: 63%, including an additive or stabilizer), and mild hyperaemia/ redness of conjunctiva (carbon number: C10-13/chlorination rate: 40%, 52%, including an additive or stabilizer) in rabbits, etc., it was classified into Category 2B.
4	Respiratory sensitization	Classification not possible	-	-	-	-	Classification is not possible since there is no data.
4	Skin sensitization	Not classified	-	-	-	-	A conclusion in humans cannot be drawn from information of no allergic reaction in the human skin application (carbon number C12/ chlorination rate 59%) and of no positive reaction in cut refrigerant production workers (unknown carbon number and chlorination rate) (EU-RAR (1999)). On the other hand, from the data such as no skin reactions (rate of carbon number C10-13/chlorination, 50%, including stabilizer) and no sensitization (rate of carbon number C10-13/chlorination, 56%, including stabilizer) in guinea pig, EU-RAR (1999) summarized that "there is no possibility of sensitization" and it was defined as "Not classified".
5	Germ cell mutagenicity	Not classified	-	-	-	-	Since it was negative in the rat dominant lethal test (carbon number: C10-12/chlorination rate: 58%) in vivo and the bone marrow rats bone marrow cell chromosome aberration test (carbon number: C10-12/chlorination rate: 58%) (EU-RAR (1999)), it was classified into "Not classified". In addition, it was negative (carbon number: C12/chlorination rate: 57%, 60%, carbon number: C10-13, chlorination rate: 50%) in the reverse mutation test employing bacterial cells in vitro and it was negative (carbon number: C10-13/chlorination rate: 56%) in the gene mutation test using Chinese hamster culture cells (EU-RAR (1999)).
6	Carcinogenicity	Category 2		Warning	H351: Suspected of causing cancer	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	Since it is classified into group 2B according to IARC 48 (1990) and is classified into Carc.Cat.3; R40 according to EU-Annex I, it is classified into Category 2. In addition, "Chlorinated Paraffins (C12, 60% Chlorine)" (CAS number 108171-26-2) is classified as R (NTP RoC 11th (2005)) in NTP, though it does not correspond to the CAS number (85535-84-8) of this substance. And also "Chlorinated Paraffins" is classified as 2B by Japan Academic Society for Industrial Hygiene (the Society's Advice (2007)). Both classifications are equivalent to GHS Category 2.
7	Reproductive toxicity	Not classified	-	-	-	-	According to EU-RAR (1999), while weight reduction of ovaria can be observed with the dose amount of 3,000mg/kg/day in the 14 day repeated oral administration study with rats (carbon number C10-12/chloridization rate 58%), no effect has been observed on male and female genital organs with the dose amount of 5,000mg/kg/day in the 13 week oral administration study (carbon number C12/chloridization rate 60%). Moreover, in the developmental toxicity study (carbon number C10-13/chloridization rate 58%) via oral administration using 25 pregnant rats in one group published in EU-RAR (1999) increase in the number of lost embryos after implantation and reduction in the number of live fetuses per mother animal have been observed at the level of 2,000mg/kg/day where death (8 out of 25 animals), weakening, salivation and reduced activities of pregnant rats can be observed. The recognized reproductive toxicity is considered to be the secondary effect of maternal toxicity and no effect on the development has been observed with the dose amount of 500mg/kg/day. Therefore, it was classified into "Not classified".
8	Specific target organ toxicity - Single exposure	Category 3 （Narcotic effects）		Warning	H336: May cause drowsiness or dizziness (narcotic effects)	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P405: Store locked up. P501: Dispose of contents/container to ...	Since hypoactivity and locomotor ataxia were seen in theoral administration test employing rats (carbon number: C12-/chlorination rate: 60%) (EU-RAR (1999)), it was classified into Category 3 (Narcotic effects).
9	Specific target organ toxicity - Repeated exposure	Not classified	-	-	-	-	According to EU-RAR (1999), in a 90-day oral administration study in rats, weight increases in the liver and kidney and mild nephritis (carbon number C10-12/chlorination ratio 58%) in males were observed at 100 mg/kg. However, it was reported in EU-RAR that "the increase in liver weight reflects peroxisome proliferation, to which humans are not highly susceptible, so this is not relevant for human health," "it is uncertain if the effects on the kidney are toxicologically significant," and "the dosage at which other effects manifest themselves in rats is greater than 100 mg/kg." Description of EU-RAR was adopted based on the expert judgment in the Review Meeting (GHS Classification Investigating Committee on substance designated by the Chemical Substance Control Enhancement Law), and it was defined as "Not classified".
10	Aspiration hazard	Classification not possible	-	-	-	-	Classification not possible due to lack of data