GHS Classification Result

Chemical Name：1-bromopropane
CAS：106-94-5

Result：
ID: 2
Classifier: Ministry of Economy, Trade and Industry （METI）
Year Classified: FY2007
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives - - - - - -
2 Flammable gases （including chemically unstable gases） - - - - - -
3 Aerosols - - - - - -
4 Oxidizing gases - - - - - -
5 Gases under pressure - - - - - -
6 Flammable liquids - - - - - -
7 Flammable solids - - - - - -
8 Self-reactive substances and mixtures - - - - - -
9 Pyrophoric liquids - - - - - -
10 Pyrophoric solids - - - - - -
11 Self-heating substances and mixtures - - - - - -
12 Substances and mixtures which, in contact with water, emit flammable gases - - - - - -
13 Oxidizing liquids - - - - - -
14 Oxidizing solids - - - - - -
15 Organic peroxides - - - - - -
16 Corrosive to metals - - - - - -

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Classification not possible - - - - Due to insufficient data, classification is not possible. LD50 value >2,000 mg/kg (the existence of fatal case is unknown) (ACGIH (2005)) of a rat and LDLo value >4,000 mg/kg of a rat (GESTIS (Access on Feb.2008)) are indicated. Therefore, although it was not classified into Category 4, suitability of Category 5 cannot be judged.
1 Acute toxicity （Dermal） Classification not possible - - - - Due to insufficient data, classification is not possible. Even if rats are administered at a dose of up to 2,000 mg/kg, there is no example of death (ACGIH (2005)). Therefore, although it was not classified into Category 4, suitability of Category 5 cannot be judged.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Since it was a liquid by the definition of GHS, it was classified into "Not applicable".
1 Acute toxicity （Inhalation: Vapours） Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Saturated vapor pressure level at 20degCis 132,000 ppm, and it was classified into Category 4 based on the LC50 value with 7,000 ppm (ACGIH (2005)) in 4-hour exposure of rats.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Classification not possible due to lack of data
2 Skin corrosion/irritation Not classified - - - - It is classified into "Not classified" based on no effect of half-blockade application for 24 hours to rats (ACGIH (2005)). However, EU Annex I is Xi; R36/ 37/ 38, and it is equivalent to the GHS Category 2.
3 Serious eye damage/eye irritation Category 2 Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		It has a description of irritation to an eye (ICSC (2004)). Although the level is unknown, since it is considered to own irritation, it is classified into Category 2. In addition, EU Annex I is Xi; R36/37/38, and is equivalent to the GHS Category 2.
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Not classified - - - - It can be classified into "Not classified" based on a conclusion of no basis of skin sensitization without signs of sensitizing potential as a result of applying a 25% Paraffin oil solution for 10 days and applying again 12 days later to guinea pig (ACGIH (2005)). In addition, the primary literatures of ACGIH (2005) are Elf Atochem (1995b), Study Number 12094 TSG;1995c. Document ID Title OAR-2002-0064:Documents available in public dockets A-2001-07, OAR-2002-0064, and and A-91-42.U.S.Environmental Protection Agency, Washington, DC (1995), but these were not available and could not be checked.
5 Germ cell mutagenicity Not classified - - - - Based on being negative in the in vivo peripheral blood micronucleus test of the inhalation course employing a mouse and being negative in the Ames test employing bacteria (NTP (2003)), it is classified into "Not classified".
6 Carcinogenicity Classification not possible - - - - Since there is no evaluation by an international rating institutions and data carcinogenicity in the range of the sources of information of Priority 1 and 2 is not indicated, classification is not possible.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Decline of reproductive functions was observed among male rats in the group administered more than 250ppm in the 2 generation reproductive toxicity study via inhalation administration using rats (ACGIH (2005)). It describes that when female animals were not administered for 4 days after baby delivery and administered from the 5th day till the 21st day except for child animals, dose dependency was observed in the prolongation of estrous cycles in F0 and F1and fertility rates and the number of embryos showed a trend to decrease. Since there is no description about maternal toxicity in this study, it is classified in Category 2. Incidentally, EU Annex 1 is Cat.2; R60 and Cat/3; R63, corresponding to GHS Category 1B and Category 2 respectively.
8 Specific target organ toxicity - Single exposure Category 3 （Respiratory tract irritation, Narcotic effects） Warning H335: May cause respiratory irritation (respiratory tract irritation, narcotic effects)
H336: May cause drowsiness or dizziness (respiratory tract irritation, narcotic effects) 		P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		For animals, since there is a description of "although piloerectionan, hypoactivity, ataxia, and dacryorrhea were discovered in the rat to which the 1 hour inhalation exposure was applied, there is no other significant pathologic effects."(ACGIH (2005)), and there is a description that, "cough, sore throat, deep sleep" as acute symptoms by inhalation exposure, "Respiratory tract is irritated. A central nervous system is affected and loss consciousness may occur." in the clause of short-term exposure (ICSC (2004)), it is classified into Category 3 (Respiratory tract irritation, Narcotic effects). In addition, EU Annex I is R36/37/38 and R67, and is equivalent to Respiratory tract irritation and Narcotic effects.
9 Specific target organ toxicity - Repeated exposure Category 1 (central nervous system) Danger H372: Cause damage to organs through prolonged or repeated exposure (central nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		For humans, it has been described that "19 years-old man who exposes to the degreasing solvent containing 95.5% 1-bromopropane in work had the symptoms of the legs and right hand numbness, and swallowing and urination difficulty, etc., two months after, and it was concluded to be due to the obstacle of the central nervous system."(ACGIH (2005)). For this case, NTP (2003) has evaluated as "The weight of the evidence is light as a human exposure case since it is only an individual case report." However, it is judged that the point indicated in ACGIH (2005), even if it is only one example, cannot be neglected and is classified into Category 1 (central nervous systems). In addition, although there is description about animals such as "abnormalities in nervous systemcentral nervous system, urinary system, blood system and lymphoid tissue in the 28-day inhalation study using rats and vacuolation of the central portion of lobule in the liver in the inhalation study of 5 days/week for 13 weeks using rats" (ACGIH (2005), the effects on laboratory animals exceed the guidance value ranges of "Category 2" after conversion. EU Annex I is Xn; R48/20, and there is a concern about specific target organ toxicity following repeated exposure by inhalation.
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） - - - - - -
11 Hazardous to the aquatic environment （Long-term） - - - - - -


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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