GHS Classification Result

Chemical Name：Peroxyacetic acid
CAS：79-21-0

Result：
ID: 1381
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - UNRTDG Class: 5.2
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Flash point: >60degC and <=90degC
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - Classified in organic peroxidies
9 Pyrophoric liquids Not classified - - - - UNRTDG Class: 5.2
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Not classified - - - - UNRTDG Class: 5.2
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not classified - - - - UNRTDG Class: 5.2
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Type F (43% or less in mass and with stabilizer) Warning H242: Heating may cause a fire P411+P235: Store at temperatures not exceeding ... degC/... degF. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P220: Keep/Store away from clothing/.../combustible materials.
P234: Keep only in original container.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P410: Protect from sunlight.
P420: Store away from other materials.
P501: Dispose of contents/container to ... 		UNRTDG Class: 5.2
16 Corrosive to metals Not classified - - - - UNRTDG Class: 5.2

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		SPECIES: Rat ENDPOINT: LD50 VALUE: 1540 mg/kg REFERENCE SOURCE: DFGOT
1 Acute toxicity （Dermal） Category 4 Warning H312: Harmful in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		It was set as Category 4 based on rabbit LD50 value: 1410mg/kg (DFGOT).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 1 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on LC50 value in 1 hour exposure on mice: 0.524mg/L (4-hour equivalent: 0.262mg/L) (DFGOT), it could be judged as the steam with almost no mist from vapor pressure. And it was classified by the ppm concentration standard. The converted value was classified as 84ppm from conversion coefficient of 1ppm = 3.11mg/m3, and it was classified as Category 1. This substance is caustic.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 1A-1C Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		From the description that severe irritation was acknowledged in the rabbit skin after open apply in 500mg (RTECS (Access on Aug 2005)), and that eschar which attains to necrosis and depths by 3-hour apply on the rabbit skin was acknowledged (DFGOT vol.7 (1996)), it judged that there were intensive skin irritations and skin corrosivenesses. So it was set as category 1A-1C.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		There is the description that blindness was acknowledged accompanying the severe inflammation accompanied by corneal clouding by the test which applied five drops of suspension 1% using the rabbit (DFGOT vol.7 (1996)). And the description that severe eye irritations was acknowledged by the test which applied 1mg of peracetic equivalent to the eye of the rabbit (RTECS (Access on Aug 2005)). And skin corrosiveness. So it was set as Category 1.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Not classified - - - - In the skin sensitization study by the Draize's method using the guinea pig of IUCLID (2000), with description DFGOT vol.7 (1996) that two sorts of tablets were negative, it is targeted at the patient who has shown the symptoms of eczema in human who used drug product including the product for skin disinfection, since the positive example was not admitted by the examination which examined skin sensitization, the description that there will not be the potential of significant causing sensitivity (PAA probably does not have significant allergic potential.), the potential which shows skin sensitization to humans was judged to estimate that it is very low, and carried out.
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Although there was a result (DFGOT) positive by the chromosome aberration test using the mammals bone marrow cells using a somatic which is an in vivo mutagenicity test, there was no result positive by the in vivo genotoxicity test using a germ cells. So it is classified into Category 2.
6 Carcinogenicity Classification not possible - - - - Classification not possible due to lack of data
7 Reproductive toxicity Classification not possible - - - - Classification not possible due to lack of data
8 Specific target organ toxicity - Single exposure Category 1 (respiratory system) Danger H370: Causes damage to organs (respiratory system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		From description that it is a corrosive substances, and pulmonary edema was observed within the range of guidance value in Category 1 in inhalation exposure test of the rat in DFGOT, it was judged that respiratory system is target organ, and considered as Category 1.
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory system, liver) Danger H372: Cause damage to organs through prolonged or repeated exposure (respiratory system, liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on description that the pulmonary inflammation and bronchopneumonia were observed in inhalation exposure to the mouse, cow, and pig (DFGOT vol.7 (1996)), and description that the hepatocellular necrosis was observed in dermal exposure to the guinea pigs (DFGOT vol.7 (1996)), respiratory tracts and liver were judged as target organs. Since these effects were observed in exposure with the guidance value range of Category 1, it was classified into Category 1.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 48-hour EC50=3.3mg/L of Crustacea (Daphnia magna) (IUCLID, 2000).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since rapidly degrading (it hydrolyzed and acetic acid and hydrogen peraxide are generated), and supposed less bio-accumulative (log Kow=-1.07(PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information