GHS Classification Result

Chemical Name:1,3,5-trinitrobenzene
CAS:99-35-4

Result:
ID: 1380
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Division 1.1 Danger H201: Explosive; mass explosion hazard P370+P380: In case of fire: Evacuate area.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P230: Keep wetted with ...
P240: Ground/bond container and receiving equipment.
P250: Do not subject to grinding/shock/.../friction.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P372: Explosion risk in case of fire.
P374: Fight fire with normal precautions from a reasonable distance.
P401: Store ...
P501: Dispose of contents/container to ...
UNRTDG Class: 1.1D
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - UNRTDG Class: 1.1D
8 Self-reactive substances and mixtures Not applicable - - - - Classified in explosives
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - UNRTDG Class: 1.1D
11 Self-heating substances and mixtures Not classified - - - - UNRTDG Class: 1.1D
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not classified - - - - UNRTDG Class: 1.1D
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Not classified - - - - UNRTDG Class: 1.1D

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
Of the LD50 values of 450mg/kg and 275mg/kg in rats (IRIS, 1997), we adopted the lower value to classify the substance as Category 3.
1 Acute toxicity (Dermal) Not classified - - - - It was set as the outside of Category from the description that death was not observed by dermal exposure of 2000mg/kg to rabbits (IRIS (1997)).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Not classified - - - - From description that irritation was not admitted by the skin irritation test using the rabbit of IRIS (1997), it carried out the outside of Category.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
It was set as Category 1 from description that the irreversible injury was admitted by the eye irritation tests using the rabbit (IRIS (1997)).
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
It was referred to as Category 1 from description in which slight skin sensitization was admitted (sensitization rates: 85%) by the skin sensitization study by the Buehler method using the guinea pigs of IRIS (1997).
5 Germ cell mutagenicity Classification not possible - - - - Classification not possible due to lack of data
6 Carcinogenicity Classification not possible - - - - Classification not possible due to lack of data
7 Reproductive toxicity Classification not possible - - - - Although the testicular degeneration is seen in the administration test in lactation period starting from pregnant or before mating using rats (IRIS(1997)), any spesific toxicity has not been observed on reproductive potential and generation of offspring. Since there was no description which clearly denies the hazard in other sources of Priority 1, it was presupposed to be unclassifiable due to insufficient data.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - Although there was description that ataxia and catalepsy were observed in IRIS (1997) in the single-dose oral study in rats, it was unknown whether these influences were temporary, and since there was no other data as same as this, it cannot be classified due to insufficient data.
9 Specific target organ toxicity - Repeated exposure Category 2 (blood, testis) Warning H373: May cause damage to organs through prolonged or repeated exposure (blood, testis) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Based on descriptions that the effect on testes and blood was observed within range of guidance value in Category 2 in the rat oral study , and that the effect on testes was observed with the dose exceeding range of guidance value in Category 2 a little in the mouse oral study (IRIS (1997)), blood and testes were considered to be target organ, and it classified into Category 2.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 96-hour LC50=380microg/L of fishes (American catfish) (AQUIRE, 2003) .
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 1, since acute toxicity was Category 1, supposed not rapidly degrading (BIOWIN), though supposed less bioaccumulative (log Kow=1.18(PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model SDS by MHLW

MHLW Website (in Japanese Only)


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