Chemical Name：p-Dimethylaminobenzenediazo sodium sulfonate; Fenaminosulf
CAS：140-56-7

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 3		Danger	H301: Toxic if swallowed	P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the LD50 value of 60mg/kg (HSDB, 2003; RTECS, 2003) in the oral administration test using female rats and rats, the substance was classified as Category 3.
1	Acute toxicity （Dermal）	Classification not possible	-	-	-	-	There is only a report of rat LD50 value >100mg/kg (HSDB, 2003) of the dermal administration test, and it cannot be classified.
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Solid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	No data available
2	Skin corrosion/irritation	Classification not possible	-	-	-	-	No data available
3	Serious eye damage/eye irritation	Classification not possible	-	-	-	-	No data available
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Classification not possible	-	-	-	-	No data available
5	Germ cell mutagenicity	Classification not possible	-	-	-	-	There is no in vivo data. And in in vitro mutagenicity test, there is an Ames positive (RTECS, 2003; NTP DB, 2006), MLA positives (NTP DB, 2006), a CHL cell chromosome aberration positive (HSDB, 2003; RTECS, 2003), CHO cell chromosome aberration negative (NTP DB, 2006). And although the response of Ames is strong, other positive reactions are not strong. Moreover, in the CHO chromosome aberration test of NTP was negative, it was not judged as 2 because of insufficient knowledge. And it cannot be classified according to a guideline.
6	Carcinogenicity	Not classified	-	-	-	-	Since it was classificationed into Group 3 (substance which cannot be classificationed into human carcinogenicity) in IARC (Supple.7, 1987), it carried out the outside of Category. In addition, carcinogenic was also negative in the two-year feed-mix administration tests for rats and mice of NTP TR101 (1978).
7	Reproductive toxicity	Classification not possible	-	-	-	-	Although fetal death and musculoskeletal effects in teratogenicity studies using female rats were reported (RTECS, 2003) it was judged to be unclassifiable due to insufficient data.
8	Specific target organ toxicity - Single exposure	Category 1 (kidney)		Danger	H370: Causes damage to organs (kidney)	P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	Since in acute oral administration in rat, renal tubular damage (HSDB, 2003) was observed at the dose of guidance levels in Category 1, it was considered as Category 1 (renal).
9	Specific target organ toxicity - Repeated exposure	Category 2 (kidney)		Warning	H373: May cause damage to organs through prolonged or repeated exposure (kidney)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	Since nephropathy is observed in feeding administration for 12 months in rat at 0.10% (= an equivalent for 1000 ppm and 50 mg/kg/day) (HSDB, 2003) and it is equivalent to the guidance value of Category 2, it was classified into Category 2 (kidney).
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 2	-	-	H401: Toxic to aquatic life	P273: Avoid release to the environment. P501: Dispose of contents/container to ...	It was classified into Category 2 from 96-hour LC50=3.7mg/L of Crustacea (Amphipod), and others (HSDB, 2004).
11	Hazardous to the aquatic environment （Long-term）	Category 2		-	H411: Toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Classified into Category 2, since acute toxicity was Category 2, and supposed not rapidly degrading (BIOWIN), though lsupposed ess bio-accumulative (log Kow=-1.66(PHYSPROP Database, 2005)).