Chemical Name：O-4-Bromo-2,5-dichlorophenyl O-methyl phenylphosphorothioate
CAS：21609-90-5

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 2		Danger	H300: Fatal if swallowed	P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the rat LD50 = 31.1mg/kg obtained by statistically processing 8 data in JMPR (WHO Pesticide Residues Series 5, 1975) in the Priority 1 document, the substance was classified as Category 2.
1	Acute toxicity （Dermal）	Category 3		Danger	H311: Toxic in contact with skin	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P280: Wear protective gloves/protective clothing/eye protection/face protection. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P322: Specific treatment （see ... on this label）. P361: Remove/Take off immediately all contaminated clothing. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ...	It was set as Category 3 according to rat LD50 = 800mg/kg (JMPR (WHO Pesticide Residues Series 5, 1975) of Priority 1 document).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Solid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Not applicable	-	-	-	-	The vapor pressure of this product is very low (it is 0.0000031Pa at 20degC), and it was considered to be difficult to carry out vapor exposure, it was out of a classification.
1	Acute toxicity （Inhalation: Dusts and mists）	Category 3		Danger	H331: Toxic if inhaled	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P311: Call a POISON CENTER or doctor/physician. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	It was set as Category 3 based on 0.9mg/kg/4H which is the lower value among the rat LC50 = 0.9 and 1.65mg/kg/4H of JMPR (WHO Pesticide Residues Series 5, 1975) in Priority 1 document.
2	Skin corrosion/irritation	Not classified	-	-	-	-	In the test of the rabbit of JMPR (WHO Pesticide Residues Series 5, 1975), since it did not indicate skin stimulative to be also drug substances and a tablet, it considered as the outside of Category.
3	Serious eye damage/eye irritation	Category 2B	-	Warning	H320: Causes eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling.	In the test of the rabbit, the eye irritations condition had disappeared in 72 hours after-exposure PDS (WHO/FAO, 1979). So it was set as Category 2B.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Classification not possible	-	-	-	-	No data available
5	Germ cell mutagenicity	Not classified	-	-	-	-	In the dominant fatality test of the mouse of JMPR (WHO Pesticide Residues Series 5, 1975), it was negative, and it is classified as the out of the Category.
6	Carcinogenicity	Not classified	-	-	-	-	In the long-term feed-mix administration test of mice by JMPR (WHO Pesticide Residues Series 5, 1975), and of rats by PDS (WHO/FAO, 1979), the carcinogenic resulting from the this product was not acknowledged. Therefore, it was carried out the outside of category.
7	Reproductive toxicity	Category 1B		Danger	H360: May damage fertility or the unborn child	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	In three-generation studies in rats of JMPR (WHO Pesticide Residues Series 5, 1975) of Priority 1 document, the survival rate of baby animals was significantly decreased at the dose (60ppm) which any specific toxicity was not observed in parent animals. So it was set as Category 1B.
8	Specific target organ toxicity - Single exposure	Category 2 (nervous system)		Warning	H371: May cause damage to organs (nervous system)	P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P405: Store locked up. P501: Dispose of contents/container to ...	Since there is description that in HSDB (2003) and SITTIG (4th, 2002) of Priority 2 document, this product which is the organophosphorus insecticide has an inhibition of cholinesterase, and it affects the human nervous system, and it was considered as Category 2 (nervous systems).
9	Specific target organ toxicity - Repeated exposure	Classification not possible	-	-	-	-	Although erythrocyte (or brain) cholinesterase inhibition was observed in rat repeated oral administration test with different dosing periods (for 90 days and for two years)(JMPR (WHO Pesticide Residues Series 5, 1975) and PDS (WHO/FAO, 1979) in Priority 1 document), since distinct toxic symptom resulting from the this product was not observed, and target organ was not specified either, it could not be classified.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from 96-hour LC50=0.0019mg/L of Crustacea (Pink shrimp) (ECETOC TR 91, and 2003).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Classified into Category 1, since acute toxicity is Category 1, supposed not rapidly degrading (BIOWIN), and bioaccumulative (log Kow=6.31 (PHYSPROP Database, 2005)).