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GHS Classification Result

Chemical Name：2-(3-Pyridyl)- piperidine sulfate
CAS：

Result：


ID:	1340
Classifier:	Inter-ministerial Committee on GHS
Year Classified:	FY2006
Reference Manual:	GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	There are no chemical groups associated with explosive properties present in the molecules.
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products
4	Oxidizing gases	Not applicable	-	-	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	-	-	-	-	Liquid (GHS definition)
6	Flammable liquids	Classification not possible	-	-	-	-	No data available
7	Flammable solids	Not applicable	-	-	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	-	-	-	-	There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9	Pyrophoric liquids	Not classified	-	-	-	-	Uses are agricultural chemicals, and even if it contacts the normal temperature air, it does not ignite spontaneously.
10	Pyrophoric solids	Not applicable	-	-	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	-	-	-	-	Test methods applicable to liquid substances are not available
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	-	-	-	-	The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Classification not possible	-	-	-	-	No data available
14	Oxidizing solids	Not applicable	-	-	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	-	-	-	-	Organic compounds containing no -0-0- structure
16	Corrosive to metals	Classification not possible	-	-	-	-	No data available

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 3		Danger	H301: Toxic if swallowed	P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the rat LD50 = 56.3mg/kg in the oral administration test(Dokubutu Gekibutu Toriatukai no Tebiki (Handbook for Handling Poisonous and Deleterious Substances) (Jiji Press Co., 2001)), the substance was classified as Category 3. [Note] We could not obtain the information about the health hazards in the Priority 1 and 2 documents, because this substance does not have a CAS number. So we used the findings on the free body, 2-(3-Pyridyl)piperidine (ID1339, CAS 494-52-0) when necessary.
1	Acute toxicity （Dermal）	Classification not possible	-	-	-	-	There is only a report of rat LD50 value >740mg/kg (guidance of toxic substance highly poisonous substance handling, Jiji Press, 2001) of the dermal administration test, and it cannot be classified.
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	No data available
2	Skin corrosion/irritation	Classification not possible	-	-	-	-	No data available
3	Serious eye damage/eye irritation	Classification not possible	-	-	-	-	No data available
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Classification not possible	-	-	-	-	No data available
5	Germ cell mutagenicity	Classification not possible	-	-	-	-	No data. In addition, in 2 -(3-pyridyl)-piperidine (ID 1339, CAS 494-52-0), there is a report of in vitro mutagenicity test (a chromosome aberration test positives (RTECS, 2006), Ames test negative (HSDB, 2002)). But there is no data of in vivo, it cannot be classified because of insufficient data.
6	Carcinogenicity	Classification not possible	-	-	-	-	No data available
7	Reproductive toxicity	Category 2		Warning	H361: Suspected of damaging fertility or the unborn child	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	Although there is no data on this substance, in 2-(3-pyridyl)-piperidine (ID 1339, CAS: 494-52-0), teratogenicity was seen in the teratogenicity study using pregnant sows (RTECS, 2006; HSDB, 2002), and it was presumed to be caused by pharmacological action on the uterus like that of nicotine (HSDB, 2002). Thus, it iwas set as Category 2. Furthermore, since nicotine (ID 608, CAS: 54-11-5) and nicotine sulfate (ID 1069, CAS: 65-30-5) were set as Category 2, this substance was judged to have the same property and was defined as Category 2.
8	Specific target organ toxicity - Single exposure	Category 2 (nervous system)		Warning	H371: May cause damage to organs (nervous system)	P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P405: Store locked up. P501: Dispose of contents/container to ...	Although there is no data of this product, since it was considered as Cateory 2 (nervous systems) based on the description that in 2-(3-pyridyl)-piperidine (ID 1339, CAS: 494-52-0), it causes hygrostomia, giddiness, distraction, vomiting, and attack in humans (HSDB, 2002), and tremor and attack were observed in the guinea pig (HSDB, 2002; RTECS, 2006), it was judged that the this product also had the same characteristic, and it was considered as Category 2 (nervous systems).
9	Specific target organ toxicity - Repeated exposure	Classification not possible	-	-	-	-	No data available
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Classification not possible	-	-	-	-	No data available
11	Hazardous to the aquatic environment （Long-term）	Classification not possible	-	-	-	-	No data available.

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations