GHS Classification Result

Chemical Name:1,4-Benzenediamine, 2-methyl-
CAS:95-70-5

Result:
ID: 1324
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - It is used as a synthetic raw material for dyes, etc. It was thought that it did not ignite spontaneously even if it contacts the air of normal temperature, and it was defined as "out of Category".
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to solid (melting point <= 140degC) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing no oxygen, fluorine and chlorine.
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
Category 3 based on SPECIES: Rat; ENDPOINT: LD50; VALUE: 102 mg/kg; REFERENCE SOURCE: RTECS(2002)
1 Acute toxicity (Dermal) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. It was set as category 3 since the "Mild (it is slight)" irritation was seen (EHC74 (1987), RTECS (2002)) when administered to the skin of rabbits.
3 Serious eye damage/eye irritation Category 2A-2B Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
It was set as Category 2A-2B from the statement considered to stimulate an eye strongly (PATTY (5th, 2001)). In addition, detailed categorization is difficult.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
In the experiment using a guinea pig, there is description that there was skin sensitization by this product (EHC74(1987), HSDB(2002)), it was referred to as Category 1. In addition, it is classified into "Sh" (the danger of skin sensitization, MAK/BAT (2005)) in German MAK Liszt.
5 Germ cell mutagenicity Not classified - - - - According to the technical guidelines, it is considered as the outside of Category because there is a negative result by the dominant fatality test (EHC74 (1987), HSDB (2002)) and in vivo micronucleus test (EHC74 (1987)) using a rat. In addition, in the Ames test, it is considered as the positive (EHC74 (1987), PATTY (5th, 2001), RTECS (2002), HSDB (2002)).
6 Carcinogenicity Not classified - - - - Since it was classificationed into "3 (it cannot classify about the carcinogenic to humans)" in IARC, it carried out the outside of Category.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
While effects such as face and head deformity, exencephaly, facial cleft were observed at the dose with no toxic effects on parent animals when this substance was administered to female mice subcutaneously or interperitoneally (EHC74 (1987)), and Catalog of Teratogenic Agents (11th, 2004). And negative results have been reported in the tests including oral administration using rats, mice and rabbit (EHC74 (1987), and Catalog of Teratogenic Agents (11th, 2004)). Since it was judged to have the effect on generation as one of the properties of this substance, it was set as Category 2. In addition, no data is found on reproductive potential.
8 Specific target organ toxicity - Single exposure Category 1 (liver, blood system) Danger H370: Causes damage to organs (liver, blood system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
Since in the document of Priority 1, there was description that exposure of this product causes liver toxicity and hemolytic anemia (PATTY (5th, 2001)), it was considered as Category 1 (liver, blood systems).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - No data available
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - No data available
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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