Chemical Name：dimethyl N,N'-[thiobis[(methylimino)carbonyloxy]]bis(thioimidoacetate)
CAS：59669-26-0

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 3		Danger	H301: Toxic if swallowed	P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ...	We compared the LD50s in male rats (96.1mg/kg) and female rats (57.4mg/kg) in the oral administration test (Agricultural Chemical Registration Data). Based on the lower of these two values (LD50 =57.4mg/kg), the substance was classified as Category 4.
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	It was set as the outside of Category based on rat LD50 >6310mg/kg of male and famales (Agricultural Chemical Registration Data) in the dermal administration test.
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Solid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Not classified	-	-	-	-	Based on that male and famale rat LC50 is >5.31mg/L in the inhalation exposure test of 4 hours, and any example of death is not acknowledged (Agricultural Chemical Registration Data). So it was set as the outside of Category
2	Skin corrosion/irritation	Not classified	-	-	-	-	In the skin irritation test using a rabbit, it carried out the outside of Category based on the statement that irritation is not admitted (Agricultural Chemical Registration Data).
3	Serious eye damage/eye irritation	Category 2B	-	Warning	H320: Causes eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling.	Although corneal cloudings, conjunctiva dropsy, redness, and secretion were observed by the eye irritation tests using a rabbit, it disappeared after 7 days (Agricultural Chemical Registration Data). So it was set as Category 2B.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Not classified	-	-	-	-	In the skin sensitivity test using a guinea pig, it carried out the outside of Category based on the statement (Agricultural Chemical Registration Data) with negativity.
5	Germ cell mutagenicity	Not classified	-	-	-	-	There is no result of human multi generation epidemiology, multi generation mutagenicity test, and germ cell in vivo mutagenicity test, and there is the description that it is negative in the somatic cell in vivo mutagenicity test (small core test using mouse erythrocytes) (Agricultural Chemical Registration Data). So it is classified as the out of the Category.
6	Carcinogenicity	Not classified	-	-	-	-	It carried out the outside of category based on the statement (Agricultural Chemical Registration Data) that there was no generating of the tumor relevant to dose in carcinogenicity tests of rats and mice.
7	Reproductive toxicity	Category 2		Warning	H361: Suspected of damaging fertility or the unborn child	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the statement (Agricultural Chemical Registration Data) that weight reduction and survival rate decrease were seen in baby animals at a dose which general toxicity was observed in parent animals in the two-generation reproduction study in rats, it was set as Category 2.
8	Specific target organ toxicity - Single exposure	Category 1 (nervous system)		Danger	H370: Causes damage to organs (nervous system)	P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	It was considered as Category 1(nerve systems) based on the description (Agricultural Chemical Registration Data ) that in a rat, at dose (20-228mg/kg) within the range of guidance value in Category 1, tremor, dacryorrhea, salivation, and piloerection were observed.
9	Specific target organ toxicity - Repeated exposure	Category 2 (kidney)		Warning	H373: May cause damage to organs through prolonged or repeated exposure (kidney)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	Based on the description that toxicity except decrease in body weight gain was not observed, and increase in the kidney weight, water intake decreased and oliguria, which were considered to be the renal effects, in administration within the range of guidance value of Category 2 (30 mg/kg) in a rat (Agricultural Chemical Registration Data), it was classified into Category 2 (kidney).
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from 48-hour EC50=0.027ppm of Crustacea (Daphnia magna) (AQUIRE, 2003).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Classified into Category 1, since acute toxicity was Category 1, supposed not rapidly degrading (BIOWIN), though supposed less bioaccumulative (log Kow=1.7 (PHYSPROP Database, 2005)).