GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：levamisole hydrochloride
CAS：16595-80-5
Result：
| ID: | 1289 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Solid (GHS definition) |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 7 | Flammable solids | Not classified | - | - | - | - | The all substance data for Poisonous and Violent Substances Control Law MSDS (Chemical Daily, 2001) states about the disposal of free body of this product (Levamisole, CAS No.6649-23-6) as "incinarate with inflammable solvent in an incinerator with afterburner and scrubber". It was considered to be flame retardant and was classified as out of Category. |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 10 | Pyrophoric solids | Not classified | - | - | - | - | The uses are for anthelmintic agents for animals and agricultural chemicals (pine tree-drying inhibitors), and even if it contacts the normal temperature air, it does not ignite spontaneously. |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | No data available |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 14 | Oxidizing solids | Classification not possible | - | - | - | - | No data available |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no -0-0- structure |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 3 |
|
Danger | H301: Toxic if swallowed |
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the oral LD50 = 180mg/kg in rats (RTECS(1997)), the substance was classified as Category 3. [Note] This substance is the chloride salt of (S)-2,3,5,6-Tetrahydro-6-phenylimidazo [2,1-b] thiazole (ID1288, CAS: 6649-23-6). Also refer to ID 1288 for the health hazards. |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | No data available |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | No data available |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | No data. In addition, (S)-2,3,5,6-tetra hydro- 6-phenylimidazo [2,1-b] thiazole (ID 1288, CAS: 6649-23-6) is considered as the out of the Category because of the result of the negativity of mouse dominant fatality test and mouse test (JECFA697 (1990)). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | No data available |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | In studies using rats or rabbits, although lowered rates of implantation and survival rate have been observed (Catalog of teratogenic agents (2004), RTECS (1997)), it cannot be classified due to insufficient data. In addition, (S)-2,3,5,6-tetra hydro-6-phenylimidazo[2,1-b]thiazole (ID 1288, CAS: 6649-23-6) is comprehensively set as "out of category" although there are some effect on generation in several studies. |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - | - | Insufficient data available. |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (blood) |
|
Danger | H372: Cause damage to organs through prolonged or repeated exposure (blood) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Since the effect on blood is observed in the rat or the dog in repeated administration of this product (RTECS (1997)), and that is observed on the human of (S)-2,3,5,6-tetrahydro-6-phenylimidazo[2,1-b]thiazole(ID1288, CAS: 6649-23-6) among the document of Priority 2, it was classified into Category 1 (blood). |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | Insufficient data available. |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |