GHS Classification Result

Chemical Name:Stannane, tributylfluoro-
CAS:1983-10-4

Result:
ID: 1277
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - It was a kind of tributyl tins, and since tributyl tins were once used as antifouling agents for hulls or fishing implements, it was considered not to ignite spontaneously even if it contacted the normal temperature air. Thus it was defined as "out of Category".
11 Self-heating substances and mixtures Classification not possible - - - - No data available
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - It was a kind of tributyl tins, and since tributyl tins was once used as a antifouling agent of a hull or fishing implements, it was considered to be stable to water and carried out the outside of category.
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - No data available
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Because the minimum lethal dose in mice is 320mg/kg (RTECS, 2004), the LD50 was estimated to be within the Category 4 range (300-2000mg/kg). So the substance was classified as Category 4.
1 Acute toxicity (Dermal) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
It was set as Category 2 based on rat inhalation LC50 value of 0.4ppm/4H (= 0.00504mg/L) (ACGIH 7th, 2001).
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. From the statement that the this product indicates skin irritation which is mild (minimal) (ATSDR, 2005) and the knowledge that the tributyl tin compound or the organotin compound indicates skin irritation (DFGOT 1, 1991-atty 5th, 2001;ATSDR, 2005), it was set to category 3
3 Serious eye damage/eye irritation Category 2A-2B Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
From knowledge that rabbit eyes severe irritation was indicated with this product, (ATSDR, 2005), in addition, eye irritation was indicated with the organic tin compound (ACGIH 7th, 2001; Patty 5th, 2001; ATSDR, 2005), it was set to Category 2A-2B. In addition, detailed categorization is difficult.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Classification not possible - - - - Although there is negative knowledge in in vitro chromosome aberration test (ATSDR, 2005), there is no in vivo data. So it cannot be classified because of insufficient data
6 Carcinogenicity Classification not possible - - - - About the this product, the negative findings in dermal exposures incomplete tests is acquired (ATSDR, 2005), and the organotin compounds is classified into A4 (it cannot classify into a the human carcinogens) in ACGIH. However, on the other hand, there is also a knowledge that a certain kind of organotin compounds induces cancer to animals (ATSDR, 2005). Therefore, its data is insufficient and it cannot be classified.
7 Reproductive toxicity Classification not possible - - - - Although a possibility that organotin compounds will affect genitalium of animals is suggested in the description (ATSDR, 2005), or tributyltin compounds is classified into Category C in DFG (a substance which does not affect human embryos and fetuses if it is within a MAK/BAT value) (MAK/BAT, 2005). But there is no data of this product, and data is insufficient, it cannot be classified..
8 Specific target organ toxicity - Single exposure Category 1 (central nervous system), Category 3 (respiratory tract irritation) Danger
Warning
H370: Causes damage to organs (central nervous system)
H335: May cause respiratory irritation (respiratory tract irritation)
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
Although there is no data of this product itself, from the influence on the central nervous systems in human as an organic tin compounds (ATSDR, 2005; ACGIH 7th, 2001; Patty 5th, 2001) and the potential of respiratory irritant (ATSDR, 2005; ACGIH 7th, 2001) being indicated, it was considered as Category 1(central nervous systems) and Category 3 (respiratory irritant).
9 Specific target organ toxicity - Repeated exposure Category 1 (immune system) Danger H372: Cause damage to organs through prolonged or repeated exposure (immune system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Although own data of this product could not be found, since the impacts of effects on the human immune system was suggested by as an organic tin compounds (ATSDR, 2005;ACGIH 7th, 2001-atty 5th, 2001), it was classified into Category 1 (immune systems).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - Insufficient data available.
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - Classification not possible due to lack of data


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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