GHS Classification Result

Chemical Name:tributyltin acetate
CAS:56-36-0

Result:
ID: 1274
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - It was a kind of tributyl tins, and since tributyl tins were once used as antifouling agents for hulls or fishing implements, it was considered not to ignite spontaneously even if it contacted the normal temperature air. Thus it was defined as "out of Category".
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to solid (melting point <= 140degC) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - It was a kind of tributyl tins, and since tributyl tins was once used as a antifouling agent of a hull or fishing implements, it was considered to be stable to water and carried out the outside of category.
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - No data available
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
Category 3 based on SPECIES: Rat; ENDPOINT: LD50; VALUE: 50-100 mg/kg (ACGIH 7th, 2001) and 99 mg/kg (Patty, 5th, 2001; RTECS, 2004)
1 Acute toxicity (Dermal) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. From the knowledge that the skin is stimulated and a burn injury is caused (HSFS, 1999), and that tributyltin compounds or organic tin compounds indicate skin irritation (DFGOT 1, 1991-atty 5th, 2001; ATSDR, 2005), it was judged that it had slight skin irritation leastways, and was set as category 3.
3 Serious eye damage/eye irritation Category 2A-2B Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
From knowledge that an eye is stimulated and a burn is caused (HSFS, 1999), and eye irritation is indicated with the organic tin compound (ACGIH 7th, 2001; Patty 5th, 2001; ATSDR, 2005), it is set as Category 2A-2B. In addition, detailed categorization is difficult.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Classification not possible - - - - No data available
6 Carcinogenicity Classification not possible - - - - The organotin compounds is classified into A4 (it cannot classify into a the human carcinogens) in ACGIH. On the other hand, there is also a knowledge that a certain kind of organotin compounds induces cancer to animals (ATSDR, 2005) and data of its this product themselves cannot be found. Therefore, it cannot be classified since the data is insufficient.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Since embryo fetus fatality and the developmental abnormality (the craniofacial and skeletal muscle system) were seen in the teratogenicity study using rat in the dose which indicates maternal toxicity (ATSDR, 2005; RTECS, 2004), it was set as Category 2.
8 Specific target organ toxicity - Single exposure Category 1 (central nervous system), Category 2 (digestive system), Category 3 (respiratory tract irritation) Danger
Warning
H370: Causes damage to organs (central nervous system)
H371: May cause damage to organs (digestive system)
H335: May cause respiratory irritation (respiratory tract irritation)
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
Since in the guidance value of Category 2, gastrointestinal bleedings was observed in the mouse (ATSDR, 2005), and the influence of the central nervous system on human (ATSDR, 2005; ACGIH 7th, 2001; Patty 5th, 2001) and the potential of respiratory irritant (ATSDR, 2005; ACGIH 7th, 2001) as an organic tin compounds are descrived, it was considered as Category 1 (central nervous system), Category 2 (alimentary system), and Category 3 (respiratory irritant).
9 Specific target organ toxicity - Repeated exposure Category 1 (immune system) Danger H372: Cause damage to organs through prolonged or repeated exposure (immune system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Although own data of this product could not be found, since the impacts of effects on the human immune system was suggested by as an organic tin compounds (ATSDR, 2005;ACGIH 7th, 2001-atty 5th, 2001), it was classified into Category 1 (immune systems).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 48-hour LC50=3.3microg TBT/L (tributyltin acetate concentration equivalent: 4.0microg/L) of Crustacea (Daphnia magna) (EHC15, 1980).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 1, since acute toxicity is Category 1,not rapidly degrading (it hydrolyzed, and tributyltin hydroxides was generated, and remained (existing chemical substances safety inspections data)), and bioaccumulative (BCF=9210 of tributyltin hydroxides (existing chemical substances safety inspections data)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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