GHS Classification Result

Chemical Name：N,N-Dimethyl-1,2,3-trithian-5-amine
CAS：31895-21-3

Result：
ID: 1245
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available
11 Self-heating substances and mixtures Classification not possible - - - - The test suitable for the solid of 140 degC or less of melting points is not established. (131.6 plus or minus 0.5 degC (Agricultural Chemical Registration Data) of melting points)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine) and the oxygen is chemically bonded only to carbon and hydrogen (but not to other elements).
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available. (Melting point: 131.6 plus or minus 0.5degC (Agricultural Chemicals Registration Data)

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In the 2 tests with rats, we compared the LD50 values for male and female. And adopted the lower value of these groups. Then, based on the value LD50 = 195mg/kg (Agricultural Chemical Registration Data) which was the lower value of the data from the two tests, the substance was classified as Category 3.
1 Acute toxicity （Dermal） Not classified - - - - Based on rat LD50 >5000mg/kg (Agricultural Chemical Registration Data) in male and female, it was set as the outside of Category.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		It was set as Category 4 based on rat LC50 = 1.02mg/L which is the lower value of LC50 = 1.02mg/L (male) and LC50 = 1.20mg/L (female) (Agricultural Chemical Registration Data).
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. It was set as Category 3 based on the statement (Agricultural Chemical Registration Data) that mild skin irritations was seen in the rabbit.
3 Serious eye damage/eye irritation Not classified - - - - In the rabbit, it set as the outside of Category based on the statement (Agricultural Chemical Registration Data) that eye irritation was not seen.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Not classified - - - - In the Maximization method using a guinea pig, it carried out the outside of Category based on the statement (Agricultural Chemical Registration Data) with negativity.
5 Germ cell mutagenicity Not classified - - - - There is no result of human multi generation epidemiology, multi generation mutagenicity test, and germ cell in vivo mutagenicity test, and there is the description that it is negative in the somatic cell in vivo mutagenicity test (small core test using mouse bone marrow cells) (Agricultural Chemical Registration Data). So it is classified as the out of the Category.
6 Carcinogenicity Not classified - - - - It carried out the outside of category based on the statement (Agricultural Chemical Registration Data) that generating of the tumor relevant to the dose was not seen in the carcinogenicity tests of rats and mice.
7 Reproductive toxicity Not classified - - - - Based on the statement (Agricultural Chemical Registration Data) that the mischief to the reproductive function or reproduction ability of parental animals relevant to dose and the mischief on child animals' generating and teratogenicity were not seen in the three-generation reproductive examination using rat and the reproductive toxicity studies using rat and rabbit (Agricultural Chemical Registration Data). So it was set as the outside of Category.
8 Specific target organ toxicity - Single exposure Category 1 (nervous system) Danger H370: Causes damage to organs (nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since there is description (Agricultural Chemical Registration Data) that it is LD50=195mg/kg and emotions insecurity, tremor, the ataxia, spasm, and opisthotonos at the dosage near LD50=195mg/kg in a rat, were seen, it was thought that it was expressed within the range of the guidance value in Category 1 (below 300mg/kg), and was considered as Category 1 (nervous systems).
9 Specific target organ toxicity - Repeated exposure Category 2 (nervous system) Warning H373: May cause damage to organs through prolonged or repeated exposure (nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on description that the decrease weight gains, feed intake reduction and water intake decreased were observed in a rat with the given dose (33.9 mg/kg) of guidance value within the limits of Category 2, and the hind-limb spasm, ataxy, feed intake reduction, and weight decrease etc. were observed in a dog with dosage (10.8-11.3 mg/kg) of guidance value within the limits of Category 2 (Agricultural Chemical Registration Data), it was classified into Category 2 (nerve systems).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 48-hour EC50=21.8microg/L of Crustacea (Daphnia magna) (Agricultural Chemical Registration Data, 2004).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1, since acute toxicity was Category 1, supposed not rapidly degrading (BIOWIN), though supposed less bioaccumulative (log Kow<4 (existing chemical safety inspections data)), .


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations

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