GHS Classification Result

Chemical Name：bis(2-chloro-1-methylethyl) ether
CAS：108-60-1

Result：
ID: 1233
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Since the flash point was 85 degC (Open Cup), it was classified as Category 4 (GHS standards: flash point being more than 60 degC, and 93 degC or less).
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - From 85 degC (o. c.) (ICSC (2003)) of flash points, ignition temperature is judged to be 70 degC or more.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Not classified - - - - Not classified because of UNRTDG Class: 6.1
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen and chlorine (but not fluorine) and these elements are chemically bonded only to carbon (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on the rat LD50s : 503.6mg/kg (male) and 698. 2mg/kg (female) in the acute oral administration toxicity test (Agricultural Chemical Registration Data), we adopted the lower value (LD50 = 503.6mg/kg) to classify the substance as category 4.
1 Acute toxicity （Dermal） Not classified - - - - It was set as the outside of Category based on the description (Agricultural Chemical Registration Data) that LD50 >2000mg/kg and no death was observed in rat acute pdermal dose toxicity studies.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Not classified - - - - Based on 4-hour exposure rat LC50 = 12.8mg/L (Agricultural Chemical Registration Data) in the acute inhalation toxicity study (Agricultural Chemical Registration Data), it was set as the outside of Category.
2 Skin corrosion/irritation Classification not possible - - - - There are no examination results of an agricultural-chemicals field object, and it cannot classify.
3 Serious eye damage/eye irritation Classification not possible - - - - There are no examination results of an pesticide ingredientsa, and it cannot classify.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Not classified - - - - Based on the publication (Agricultural Chemical Registration Data) that the examination of the Maximization method using a guinea pig did not indicate skin sensitization, it considered as the outside of Category.
5 Germ cell mutagenicity Not classified - - - - There is no result of human human multi generation epidemiology, multi generation mutagenicity test, and germ cell in vivo mutagenicity test, and there is the description that it is negative in the somatic cell in vivo mutagenicity test (small core test using mouse) (Agricultural Chemical Registration Data). So it is classified as the out of the Category.
6 Carcinogenicity Not classified - - - - It was carried out the outside of Category based on the statement (Agricultural Chemical Registration Data) that it did not admit the increase in the neoplastic lesion relevant to compound administrations in two carcinogenicity tests of rats, and a carcinogenicity test of mice.
7 Reproductive toxicity Not classified - - - - Based on the publication that the effects on reproductive potential was not acknowledged in the three-generation reproduction study of rats, and the effects on fetuses and embryos was acknowledged in the teratogenicity study of rats and rabbits (Agricultural Chemical Registration Data). So it was set as the outside of Category.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - Insufficient data available.
9 Specific target organ toxicity - Repeated exposure Not classified - - - - Based on the description that only the decreased weight gains and feed intake reduction are observed in rat's four-week repeated oral administration neurotoxicity study with dosage of 100 mg/kg/day within a guidance value maximum of Category 2 (Agricultural Chemical Registration Data), it carried out the outside of Category.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 3 from 48-hour EC50=31.9mg/L of Crustacea (Daphnia magna) (Agricultural Chemical Registration Data, 2004).
11 Hazardous to the aquatic environment （Long-term） Category 3 - - H412: Harmful to aquatic life with long lasting effects P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 3, since acute toxicity was Category 3 and not rapidly degrading (BOD: 0% (existing chemical safety inspections data)), though less bio-accumulative (BCF=12 (existing chemical safety inspections data)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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