GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：dichloroacetic acid
CAS：79-43-6
Result：
| ID: | 1231 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Not classified | - | - | - | - | Non-combustible (ICSC(J), 2000). |
| 7 | Flammable solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. |
| 9 | Pyrophoric liquids | Not classified | - | - | - | - | Not combustible (ICSC (J), 2000) |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Not classified | - | - | - | - | Not combustible (ICSC(J) (2000)) |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Organic compounds containing oxygen and chlorine (but not fluorine) and these elements are chemically bonded only to carbon and hydrogen (but not to other elements). |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no -0-0- structure |
| 16 | Corrosive to metals | Category 1 |
|
Warning | H290: May be corrosive to metals |
P234: Keep only in original container. P390: Absorb spillage to prevent material-damage. P406: Store in corrosive resistant/... container with a resistant inner liner. |
UNRTDG is classified into 8 and II according to the UNRTDG No. (1764). Since ICSC (J) (2000) had the description "it is strong acid and many metals is corroded", it was thought that there was corrosion behavior and it was set as Category 1. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 5 | - | Warning | H303: May be harmful if swallowed | P312: Call a POISON CENTER or doctor/physician if you feel unwell. | Based the rat oral LD50 value : 2820-4480mg/kg (ACGIH (7th, 2005)), it was classified as Category 5. |
| 1 | Acute toxicity （Dermal） | Category 3 |
|
Danger | H311: Toxic in contact with skin |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P280: Wear protective gloves/protective clothing/eye protection/face protection. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P322: Specific treatment （see ... on this label）. P361: Remove/Take off immediately all contaminated clothing. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ... |
Considering rabbit dermal LD50 = 510mg/kg (ACGIH (7th, 2005), RTECS (2004)), it was set as Category 3. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available |
| 2 | Skin corrosion/irritation | Category 1A-1C |
|
Danger | H314: Causes severe skin burns and eye damage |
P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ... |
Since "Severe (severe) "reaction was seen in Standard Draize Test to a rabbit (ACGIH(7th, 2005); RTECS (2004)), and there was description which indicates caustic to human's skin (ICSC (J) (2000)) and produces the severe stimulativeness and the severe burn (SITTIG(4th, 2002); HSFS (1999)), it was set as category 1A-1C. In addition, further categorizing from this data is difficult. |
| 3 | Serious eye damage/eye irritation | Category 1 |
|
Danger | H318: Causes serious eye damage |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. |
There is the description that severe irritation is indicated for the eye of rabbit (ACGIH (7th, 2005)), caustic is indicated to the human eye (ICSC(J)(2000), and SITTIG(4th, 2002)), an irreversible obstacle is produced in the human eye (SITTIG(4th, 2005), and HSFS(1999)). Moreover, it was classified into Category 1 to the skin. So it was set to Category 1. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available |
| 5 | Germ cell mutagenicity | Category 2 |
|
Warning | H341: Suspected of causing genetic defects |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
There is the positive result at the in vivo small core test using a mouse erythrocytes of peripheral blood (IARC84(2004);IRIS (2003)), and gene mutation test of the liver using a transgenic mice (IARC84 (2004)). So it is classified into Category 2. In addition, although there is the inconsistent report that it is positive/ negative in the in in vitro mutagenicity test (an Ames test, a chromosome aberration test) and in in vivo small core test, this material is considered to has the genotoxicity in in vitro(IARC84 (2004)). |
| 6 | Carcinogenicity | Category 2 |
|
Warning | H351: Suspected of causing cancer |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
This product is classified inot "Group 2B (carcinogenic may be indicated to humans)" by IARC (IARC84 (2004)), and "A3 (although it is the substance with which carcinogenic was ascertained to the animal, the relevancy to human is categoried into unknown"(ACGIH (7th, 2005)). Therefore, it was set to category 2 according to the technical indicator. |
| 7 | Reproductive toxicity | Category 2 |
|
Warning | H361: Suspected of damaging fertility or the unborn child |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
The malformations of the heart is seen in the fetus by oral administration to pregnant rats in the dose which indicates maternal toxicity, and moreover, the malformation of a sperm, testicular atrophy, etc. are seen administration to male rats. (All are ACGIH (7th, 2005), IARC84 (2004), HSDB (2003), Catalog of teratogenic agents (2004)). And it was considered as the testicular disorders (ACGIH (7th, 2005)), it was set as Category 2. |
| 8 | Specific target organ toxicity - Single exposure | Category 2 (Inhalation: lung) |
|
Warning | H371: May cause damage to organs (Inhalation: lung) |
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P405: Store locked up. P501: Dispose of contents/container to ... |
Since there was description that inhalation of vapor indicates caustic to the human respiratory tract, and pulmonary edemas may be caused (ICSC (J) (2000), SITTIG (4th, 2002), HSFS (1999)) in the document of Priority 2 , it was considered as Category 2 (inhalation: lungs). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (nervous system), Category 2 (liver, kidney, testis) |
|
Danger Warning |
H372: Cause damage to organs through prolonged or repeated exposure (nervous system) H373: May cause damage to organs through prolonged or repeated exposure (liver, kidney, testis) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Since there is description that influence was observed in the nervous system (stillness action, and peripheral neuropathy) as a result of dose to the humans of this product (IARC84(2004), and IRIS(2003), the document of Priority 1) and that enlarged liver/hepatomegaly, etc., renal syndrome, testicular atrophy etc. were observed in the administration to a mouse and a rat with the given dose classified into Category 2 according to a guidance value (ACGIH(7th, 2005), IARC84(2004), IRIS(2003), and HSDB(2003)), it was classified into Category 1 (nervous systems) and Category 2 (liver, the kidney, testes). |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Not classified | - | - | - | - | It carried out the outside of Category from 24-hour EC50=106mg/L of Crustacea (Daphnia magna) (AQUIRE, 2003). |
| 11 | Hazardous to the aquatic environment （Long-term） | Not classified | - | - | - | - | Since not water-insoluble (water solubility=1000000mg/L(PHYSPROP Database, 2005)) and acute toxicity is low. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |