GHS Classification Result

Chemical Name:cartap hydrochloride
CAS:15263-52-2

Result:
ID: 1229
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Non-pyrophoric when in contact with air at a room temperature and used as agricultural chemicals.
11 Self-heating substances and mixtures Classification not possible - - - - No data available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - No data available
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Although HSDB (2003) has the description "iron, copper and zinc are corroded", test methods suitable for solid materials are not established.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Based on the LD50 = 325mg/kg in rats from Agricultural Chemical Registration Data (1994), the substance was classified as Category 4.
1 Acute toxicity (Dermal) Category 5 - Warning H313: May be harmful in contact with skin P312: Call a POISON CENTER or doctor/physician if you feel unwell. Rat LD50> 2000mg/kg (Agricultural Chemical Registration Data (1994)). But death was observed at 1000mg/kg, it was set as Category 5.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Not applicable - - - - The vapor pressure of this product is very low (it is 0.000025Pa at 25degC), and it was considered to be difficult to carry out vapor exposure. So it was out of a classification.
1 Acute toxicity (Inhalation: Dusts and mists) Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
It was set as Category 4 based on rat LC50 = 3.5mg/L/4H (Agricultural Chemical Registration Data (non-submitted)).
2 Skin corrosion/irritation Category 1A-1C Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
All of the result of the examination (an original object and five examinations by a tablet) of the rabbit of Agricultural Chemical Registration Data (1994) were corresponsive to the outside of category. But technical products of this product is valued pH2 or less, and it was set to category 1A-1C. In addition, further categorizing is difficult.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
As for the result of the examination of the rabbit (original object and six examinations by pharmaceutical) of Agricultural Chemical Registration Data (1994), most were equivalent to out of Category (only one examination of pharmaceutical is equivalent to Category 2B), the original object of this product is pH2 or less. So it was set to Category 1.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Not classified - - - - In the test (technical products and formulations) of the guinea pigs of Agricultural Chemical Registration Data (1994), since skin sensitization was not accepted, it carried out the outside of Category.
5 Germ cell mutagenicity Not classified - - - - In Agricultural Chemical Registration Data (1994), there is the negative result of the dominant fatality test of the mouse, in vivo chromosome aberration test of a mouse and rat, and a bacterial reverse mutation test. So it is classified as the out of the Category.
6 Carcinogenicity Not classified - - - - Since the long-term feed-mix administrations carcinogenicity tests of rats and mice in Agricultural Chemical Registration Data (1994) did not acknowledge carcinogenicity resulting from the this product, it was carried out the outside of Category.
7 Reproductive toxicity Not classified - - - - In the two-generation study of a rat (a reproductive study and a teratogenicity study) and the teratogenicity study of a mouse, rat, hamster, and rabbit (Agricultural Chemical Registration Data (1994)), since the mischief resulting from this product was not acknowledged, it was set as the outside of Category.
8 Specific target organ toxicity - Single exposure Category 1 (nervous system) Danger H370: Causes damage to organs (nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
Neurological symptoms, such as a spasm and tremor, were seen in acute oral toxicity tests 3 examination in both rat and mice of Agricultural Chemical Registration Data (1994). Although the existence of the neurologic symptoms in the minimum dosage group to which death animals were not observed in any of three examinations is unknown, neurologic symptoms are discovered at dosage lower than LD50 value. Since all the dose were within the range of the guidance value of Category 1, it was considered as Category 1 (nervous system ).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In the subacute oral toxicity examination (three months) , and the chronic oral toxicity study (80 to 104 weeks) to a rat and a mouse, remarkable toxicity was not observed (Agricultural Chemical Registration Data (1994)) , so it cannot be classified because it cannot specify the target organs.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 48-hour EC50=0.065mg/L of Crustacea (Daphnia magna) (Agricultural Chemical Registration Data, 2001).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 1, since acute toxicity was Category 1, supposed not rapidly degrading (BIOWIN), though supposed less bioaccumulative (log Kow=-0.95(PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


To GHS Information