GHS Classification Result

Chemical Name：Fluvalinate
CAS：69409-94-5

Result：
ID: 1219
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		There is a description of flash point being 90 degC (as tau-Fluvalinate of CAS No.102851-06-9) in PM (13th, 2003), and it was classified as Category 4.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Uses are agricultural chemicals, and even if it contacts the normal temperature air, it does not ignite spontaneously.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen, fluorine and chlorine and these elements are chemically bonded only to carbon (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Classification not possible due to lack of data though "Non-corrosive to slightly corrosive, depending upon the metal" (HSDB, 2003)

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the oral LD50 = 261mg/kg in rats (RTECS(2003), HSDB(2003)), the substance was classified as Category 3.
1 Acute toxicity （Dermal） Not classified - - - - It was set as the outside of Category based on rat dermal LD50 >20mg/kg (RTECS (2003)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the inhalation to a rat LC50 (4hr) = 0.439ppm (since the saturated concentration is 0.002mg/L, it is presumed that the inhalation study is performed in mist conditions) (RTECS (2003)), it was set as Category 2.
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. Since there was description that it has "Mild (it is slight)" irritation to a rabbit and that burning sensations is given to human skin by exposures of synthetic pyrethroids compounds (all are HSDB(s) (2003)), it was set as Category 3.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		In STANDARD DRAIZE TEST to a rabbit, from the description that there is "mild" irritation (RTECS(2003)), and the description that "moderate" eye irritation is shown to a rabbit, and pyrethroid compound gives a stimulation to the human eye (HSDB(2003)), it is set as Category 2B.
4 Respiratory sensitization Classification not possible - - - - Since data is insufficient. In addition, although it was not what specified the this product, description that a pyrethroid compounds causes pneumallergie was seen (HSDB (2003)).
4 Skin sensitization Not classified - - - - Since effect was not seen in the guinea pig skin sensitization test (the Buehler method) using the 20% wettable powders of this substance (Pesticide Science Society of Japan (1990)), it carried out the outside of Category.
5 Germ cell mutagenicity Classification not possible - - - - Although there is negative knowledge in in vitro mutagenicity test (Ames test,chromosome aberration test) (Pesticide Science Society of Japan (1990)), there is no in vivo data and it cannot be classified because of insufficient data.
6 Carcinogenicity Not classified - - - - Since the finding which suggests carcinogenicity in the carcinogenicity tests using rats and mouse was not acknowledged, (Pesticide Science Society of Japan (1990)), it carried out the outside of category.
7 Reproductive toxicity Not classified - - - - Since effect was not seen in the two-generation fertility study of a rat and the teratogenicity test of a rat and rabbit (Pesticide Science Society of Japan (1990)), it t was set as the outside of Category.
8 Specific target organ toxicity - Single exposure Category 1 (nervous system) Danger H370: Causes damage to organs (nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since at a single dose (pathway unknown) in the pharmacological tests using rat and a mouse, the influence on a central nervous system (hypothermia, muscle relaxant effect, lack of motor coordination) and the influence on the peripheral nervous system (mild muscle contraction) were observed in the guidance value of Category 1 (Pesticide Science Society of Japan, 1990), it was considered as Category 1 (nervous systems). In addition, synthetic pyrethroid compound is nerve poison which acts on axonal of peripheral and central nervous system by making a sodium channel into site of action (EHC (J) 98 (1990)).
9 Specific target organ toxicity - Repeated exposure Category 1 (skin) Danger H372: Cause damage to organs through prolonged or repeated exposure (skin) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Since the dermatoses were observed in the 13-week subacute toxicity study in a rat with the guidance value of Category 1 (Journal of Pesticide Science of Japan (1990)), it was classified into Category 1 (skin). In addition, although synthetic pyrethroids is a neurotoxin acting on axon of peripheral and central nervous system (EHC(J)98(1990)), the acculate effect on the nerve is not indicated in the repeated exposure test using a rat, a mouse, and a dog (Journal of Pesticide Science of Japan (1990)).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 96-hour LC50=0.018ppb of Crustacea (Mysid shrimp) (AQUIRE, 2003).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1, since acute toxicity is Category 1, supposed not rapidly degrading (BIOWIN), and bioaccumulative (log Kow=6.81 (PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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