Chemical Name：alpha-cyano-3-phenoxybenzyl 2,2-dimethyl-3-(1,2,2,2-tetrabromoethyl)cyclopropanecarboxylate
CAS：66841-25-6

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 3		Danger	H301: Toxic if swallowed	P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ...	We compared the LD50s in male rats (70.6mg/kg) and female rats (88.1mg/kg) in the oral administration test (Agricultural Chemical Registration Data). Based on the lower of these two values, the substance was classified as Category 3.
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	Based on rat LD50 >5000mg/kg of male and famale (Agricultural Chemical Registration Data) in the dermal administration test, it was set as the outside of Category.
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Solid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	Male and female rat LC50 was >0.286mg/L in the inhalation exposure test (Agricultural Chemical Registration Data). And LC50 value was not calculated, it cannot be classified.
2	Skin corrosion/irritation	Category 3	-	Warning	H316: Causes mild skin irritation	P332+P313: If skin irritation occurs: Get medical advice/attention.	It was set as Category 3 based the publication (Agricultural Chemical Registration Data) of the skin irritation test using a rabbit, in which slight erythema of 5/6 animal were seen after 24 hours after, very slight erythema of 3/6 animal were seen after 72 hours, and all of them were disappeared six days after.
3	Serious eye damage/eye irritation	Category 2A		Warning	H319: Causes serious eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection.	By the eye irritation tests using a rabbit, conjunctival edemas and redness were seen in 2/6 animal, and blue haze was seen in 5/6 animal after 24 hours. And conjunctival edemas was seen in 1/6 animal, conjunctival redness was seen in 2/6 animals, and blue haze was seen in 4/6 animal after 48 hours (severity of the condition is reduced, respectively). And it disappeared altogether after 11 days (Agricultural Chemical Registration Data). Based on the this statement, it was set as Category 2A.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Not classified	-	-	-	-	In the skin sensitivity test using a guinea pig, it carried out the outside of Category based on the statement (Agricultural Chemical Registration Data) with negativity.
5	Germ cell mutagenicity	Not classified	-	-	-	-	There is no result of human multi generation epidemiology, multi generation mutagenicity test, and germ cell in vivo mutagenicity test, and there is the description that it is negative in the somatic cell in vivo mutagenicity test (small core test using mouse bone marrow cells) (Agricultural Chemical Registration Data). So it is classified as the out of the Category.
6	Carcinogenicity	Not classified	-	-	-	-	It carried out the outside of category based on the statement (Agricultural Chemical Registration Data) that the increase in tumorigenic frequency relevant to dose is not admitted in any of studies using rats and mouse.
7	Reproductive toxicity	Not classified	-	-	-	-	In the two-generation reproduction examination of rat, two teratogenicity tests of rat, and the teratogenicity test of rabbit, based on the publication (Agricultural Chemical Registration Data) that the effects to reproduction and teratogenicity was not acknowledged and mischief were not acknowledged without the inhibitation of weight gains were seen in fetal animals given in the dose in which general toxicity was acknowledged in parent animals. So it is considered as the outside of Category.
8	Specific target organ toxicity - Single exposure	Category 1 (nervous system)		Danger	H370: Causes damage to organs (nervous system)	P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	It was considered as Category 1 (nerve systems) based on the descrption (Agricultural Chemical Registration Data ) that the symptoms such as face washing action, a spasm, ananastasia, and proneness conditions at the dose (more than 50mg/kg) within the range of guidance value in Category 1 were observed.
9	Specific target organ toxicity - Repeated exposure	Category 2 (systemic toxicity)		Warning	H373: May cause damage to organs through prolonged or repeated exposure (systemic toxicity)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	In two 13-week subacute oral toxicity examinations to a rat, It is classified into Category 2 (systemic) based on description that symptoms as decreased food consumption, loss weight of various organs, change of a blood biochemical value, decreased activity level and respiratory distress were observed in guidance value within the limits (16-18 mg/kg) of Category 2 (Agricultural Chemical Registration Data) .
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from 48-hour EC50=0.091microg/L of Crustacea (Daphnia magna) (Agricultural Chemical Registration Data, 2005).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Classified into Category 1, since acute toxicity was Category 1, not rapidly degrading (BIOWIN), though supposed less bioaccumulative (BCF=314(Agricultural Chemical Registration Data, 1985))).