GHS Classification Result

Chemical Name:thiacloprid
CAS:111988-49-9

Result:
ID: 1187
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available
11 Self-heating substances and mixtures Classification not possible - - - - The test suitable for the solid state material with a melting point of 140 degC or less has not been established. (136 degC of melting points)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing chlorine (but not oxygen and fluorine) and the chlorine is chemically bonded only to carbon (but not to other elements).
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available (Melting point: 136degC)

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
We compared the LD50s in male rats (836mg/kg) and female rats (444mg/kg) (Agricultural Chemical Registration Data) in the oral administration test. Based on the lower of these two values, the substance was classified as Category 4.
1 Acute toxicity (Dermal) Not classified - - - - It was set as the outside of Category based on rat LD50 >2000mg/kg (Agricultural Chemical Registration Data) for both male and female in the dermal administration test.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
It was set as category 4 based on that the female rat LC50 of the inhalation exposure examination is about 1.223mg/L (Agricultural Chemical Registration Data).
2 Skin corrosion/irritation Not classified - - - - It carried out the outside of Category based on the description that there is no stimulativeness in the skin irritation test using rabbits (Agricultural Chemical Registration Data).
3 Serious eye damage/eye irritation Not classified - - - - Due to the description that it has no irritation in the eye irritation tests using rabbit (Agricultural Chemical Registration Data), it was set as the outsaide of Category.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Not classified - - - - In the Maximization method using a guinea pig, it carried out the outside of Category based on the statement (Agricultural Chemical Registration Data) with negativity.
5 Germ cell mutagenicity Not classified - - - - There is no result of human multi generation epidemiology, multi generation mutagenicity test, and germ cell in vivo mutagenicity test, and there is the description that it is negative in the somatic cell in vivo mutagenicity test (small core test using mouse bone marrow) (Agricultural Chemical Registration Data). So it is classified as the out of the Category.
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Thyroid follicle cell adenoma and uterine adenocarcinomas are observed in rat by high-dose group (more than 500ppm), and the generation frequency of luteoma increases in the mouse. These are considered to be the pathological changes resulting from liver drug metabolism enzyme induction (Agricultural Chemical Registration Data). Based on these descripitons, it was classified into Category 2.
7 Reproductive toxicity Not classified - - - - In studies using rats and rabbits, although there was a publication (Agricultural Chemical Registration Data) that the inhibition of weight gains and ossification delayed were seen in the fetas animals in the dose which indicates general toxicity to a parental animals, the other toxicity was not indicated. So it was set as the outside of Category.
8 Specific target organ toxicity - Single exposure Category 1 (nervous system) Danger H370: Causes damage to organs (nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
It was considered as Category 1 (nerve systems) based on the descrption (Agricultural Chemical Registration Data ) that piloerection, fall of an active and reactant, tremor, imperfect reflective and breathing abnormality were observed in rats at the dose of 300mg/kg within the range of guidance value in Category 1 .
9 Specific target organ toxicity - Repeated exposure Category 2 (liver) Warning H373: May cause damage to organs through prolonged or repeated exposure (liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Because of the description of confirming effects on liver in rats (changes of tissue in livers, an increase in liver weight, increasing concentration of cholesterol and protein, and increased enzymes), with the dosage (28.6mg/kg and 36.5mg/kg) within the limits of guidance value in Category 2 (Agricultural Chemical Registration Data), it was classifried into Category 2 (liver).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
It was classified into Category 3 from ErC50=90.7mg/L of algae (Green algae (Agricultural Chemical Registration Data, 2004).
11 Hazardous to the aquatic environment (Long-term) Category 3 - - H412: Harmful to aquatic life with long lasting effects P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
Classified into Category 3, since acute toxicity was Category 3 and rapid degradability and bioaccumulation potential are unknown.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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