GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Ethyl chloroacetate
CAS：105-39-5
Result：
| ID: | 1182 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Category 3 |
|
Warning | H226: Flammable liquid and vapour |
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P233: Keep container tightly closed. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ... |
Flash point: 53degC(C.C.) (ICSC(J), 2001). UNRTDG No. 1181, Class: 6.1(3); PG II. |
| 7 | Flammable solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. |
| 9 | Pyrophoric liquids | Not classified | - | - | - | - | UNRTDG is classified into 6.1 (3) and II according to the U.N. number (1181) peculiar to a substance. Since 4.2 was not attached, it considered as the outside of Category. |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Organic compounds containing oxygen and chlorine (but not fluorine) and these elements are chemically bonded only to carbon (but not to other elements). |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no -0-0- structure |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | UNRTDG is classified into 6.1 (3) and II according to the UNRTDG No. (1181). Although 8 is not attached, since the data which negates corrosion behavior is not found, it cannot be classified. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 3 |
|
Danger | H301: Toxic if swallowed |
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the calculated LD50 = 96.8mg/kg based on the rat oral LD50 values: 50, 180, 180 and 235mg/kg (PATTY (5th, 2001), RTECS (1999), IUCLID (2000)), the substance was classified as Category 3. |
| 1 | Acute toxicity （Dermal） | Category 2 |
|
Danger | H310: Fatal in contact with skin |
P302+P350: IF ON SKIN: Gently wash with plenty of soap and water. P262: Do not get in eyes, on skin, or on clothing. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P322: Specific treatment （see ... on this label）. P361: Remove/Take off immediately all contaminated clothing. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ... |
The lower rabbit LD50 = 230mg/kg. (Based on rabbit LD50 = 230mg/kg and 335mg/kg (both are IUCLID (2000))). Rat LD50 = 161mg/kg (RTECS (1999), IUCLID (2000)). It was set as Category 2 from high toxic rat LD50 = 161mg/kg. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available |
| 2 | Skin corrosion/irritation | Category 2 |
|
Warning | H315: Causes skin irritation |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P362: Take off contaminated clothing and wash before reuse. |
Since the experimental result of a rabbit (the irritation of moderately, IUCLID (2000)), and that "skin is stimulated to humans (ICSC (J) (2001)", and "the skin was seriously stimulated by contact to humans" (SITTIG (4th, 2002), HSFS (1999)), it was set as category 2. |
| 3 | Serious eye damage/eye irritation | Category 2A |
|
Warning | H319: Causes serious eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. |
Due to the descriptions of the result of the experiment to the rabit (Severe (RTECS (1999)) , severe irritation (IUCLID (2000)), "irritation to human eye severely (ICSC (J) (2001))", "irritation to the eye seriously" (HSDB (2003), SITTIG (4th, 2002), IUCLID (2000)), it was classified into Category 2A. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
| 4 | Skin sensitization | Category 1 |
|
Warning | H317: May cause an allergic skin reaction |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ... |
Among the document of Priority 2, since there is description that a positivity is shown in Maximization Test using a guinea pig (IUCLID(2000)), and the description (ICSC(J)(2001)) to humans "sensitization of the skin may be carried out by repetition or long-term contact", according to the technical indicator, it was considered as Category 1. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | There is only a Ames test negative database (IUCLID (2000)) of in vitro, it cannot be classified according to technical guidelines flow. |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | The negative result was obtained by dermal or subcutaneous administration in the experiment in mouse (IUCLID (2000)). But only female was used, and data is insufficient. Therefore, it cannot be classified. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | No data available |
| 8 | Specific target organ toxicity - Single exposure | Category 2 (respiratory system) |
|
Warning | H371: May cause damage to organs (respiratory system) |
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P405: Store locked up. P501: Dispose of contents/container to ... |
It was considered as Category 2 (respiratory systems) based on the description that it stimulates the human respiratory tract (ICSC (J) (2001), SITTIG (4th, 2002), and causes pulmonary edemas to humans (HSDB (2003), SITTIG (4th, 2002)) in Prioirty 2. |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | Although the description in Priority 2 that there is a possibility of causing damage to lungs (SITTIG (4th, 2002)), it was presupposed that it could not be classified for lack of data. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 2 | - | - | H401: Toxic to aquatic life |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
It was classified into Category 2 from 96-hour LC50=1.48mg/L of fishes (Zebrafish) (IUCLID, 2000) . |
| 11 | Hazardous to the aquatic environment （Long-term） | Not classified | - | - | - | - | Since rapidly degrading (BOD: 75% (IUCLID, 2000)), and less bio-accumulative (log Kow=0.94 (PHYSPROP Database, 2005)). |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |