GHS Classification Result

Chemical Name:N-[4-(p-Tolyloxy)benzyl]-1-methyl-3-ethyl-4-chloro-1H-pyrazole-5-carboxamide
CAS:129558-76-5

Result:
ID: 1180
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - Not classified because of the oxygen balance calculated at -210.5, lower than -200 of the criteria, though containing nitrogen atoms adjacent to each other as chemical groups associated with explosive properties present.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available
8 Self-reactive substances and mixtures Classification not possible - - - - Classification not possible due to lack of data, though the substance contains nitrogen atoms adjacent to each other as chemical groups with explosive or self-reactive properties present
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available
11 Self-heating substances and mixtures Classification not possible - - - - The test suitable for the solid with a melting point of 140 degC or less has not been established. (87.8 - 88.2 degC melting points)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing oxygen and chlorine (but not fluorine) and the oxygen and chlorine are chemically bonded only to carbon.
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available (Melting point: 87.8 to 88.2degC)

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
In the 3 tests with rats, we compared the LD50 values for male and female and selected the lower value of these groups. Then based on the calculated LD50 = 77.2mg/kg (Agricultural Chemical Registration Data), the substance was classified as Category 3.
1 Acute toxicity (Dermal) Not classified - - - - It was set as the outside of Category based on the description (Agricultural Chemical Registration Data) that death is not observed in administration at 2000mg/kg (male) and 3000mg/kg (female) in rats.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
The value of the lower one was adopted among LC50 values of a male and females. And it was set as category 4 based on LC50 = 1.50mg/L (Agricultural Chemical Registration Data).
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. It was set as category 3 based on the statement (Agricultural Chemical Registration Data) that erythema was seen until 48 hours after setting to the rabbit, but it is very slight, and it was disappeared 72 hours afterward.
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
Although the irritant effect was obserbed in the iris after one hour, it disappeared after 24 hours. And although redness and edema were observed in the conjunctiva, it disappeared after 14 days. Based on these results (Agricultural Chemical Registration Data), it was classified into Category 2A.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Not classified - - - - Based on the statement (Agricultural Chemical Registration Data) with negativity by the Maximization method of a guinea pig, it carried out the outside of Category.
5 Germ cell mutagenicity Not classified - - - - There is no multi generation epidemiology, multi generations mutagenicity tests, data from germ cell mutagenicity test, and there is the description that it is negative in the somatic cell in vivo mutagenicity test (in vivo small core test using the red blood cells of mouse) (Agricultural Chemical Registration Data). So it is classified as the out of the Category.
6 Carcinogenicity Not classified - - - - By the carcinogenicity test in rat and mouse, based on the description that carcinogenicity was not observed (Agricultural Chemical Registration Data), it was out of the Category.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
In the reproduction toxicity study using a rat, abnormal labor (hard labor, delay delivery), extention of the gestational age, and decline in a a delivery rate and birthrate were found for the parental animals by the dose of general toxicity, and the influence of growth on a child animal, reduction of the number of delivery survival children, decrease of perinatal and the four-day probability of survival and delay of a righting reflective formation day were acknowledged. Although teratogenicity was not seen by the dose which indicates general toxicity to parental animals by the teratogenicity study using a rat, low values of fetal body weight and metacarpal bone ossification delayed were seen (Agricultural Chemical Registration Data). It was set as Category 2 based on the above information.
8 Specific target organ toxicity - Single exposure Category 1 (systemic toxicity) Danger H370: Causes damage to organs (systemic toxicity) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
It was considered as Category 1(systemic) based on the description (Agricultural Chemical Registration Data )that abdominal position, side-lying position, round back position, the fall of spontaneous movement, walk malfunction, irregular breath or dyspnea, diarrhea, and contamination of an abdomen part, loss of activity and hypothermia were observed in the rat and the mouse at dose within the range of guidance value in Category 1 (dosage near LD50 value).
9 Specific target organ toxicity - Repeated exposure Category 1 (liver, pancreas, genitalia), Category 2 (heart) Danger
Warning
H372: Cause damage to organs through prolonged or repeated exposure (liver, pancreas, genitalia)
H373: May cause damage to organs through prolonged or repeated exposure (heart)
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
In rats with administration (4.78mg/kg or 9.33mg/kg) within the guidance value limits of Category 1, there is a mention of effects such as decrease leucocyte numbers, elevation of glucose, suppressed of total protein and albumin; elevation of gamma GT and urea nitrogens; suppressed of triglycerides; hepatocellular hypertrophy; hypertrophy of pancreas acinar cells; hypersecretion of harderian glands; increase of mesenteric lymph nodes mast cells; nypertrophy of submandibular acinar cells; miniaturization of seminal vesicles and prostate glands; miniaturization of ovaries, uterus, and vaginae; atrophy of ovaries and uteri; low values of ovarian weight. Moreover, in mice with administration (15.9mg/kg or 46.2mg/kg) within the guidance value limits of Category 2, there is a mention of decrease weight gain, decreased food consumption, elevation of GOT, increase of heart relative weight, and increase of liver relative weight (Agricultural Chemical Registration Data). Based on the above information, it was classified into Category 1 (liver, pancreas, genitalia) and Category 2 (heart).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Not classified - - - - Since it was suggested from 72-hour ErC50>0.76 mg/L of algae (Green algae) (Agricultural Chemical Registration Data) that relevant toxicity is not indicated in the water solubility (0.087mg/L (an Agricultural Chemicals abstracts, 2004)) of this substance, it considered as the outside of Category.
11 Hazardous to the aquatic environment (Long-term) Category 4 - - H413: May cause long lasting harmful effects to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
Classified into Category 4, since rapid degradability is unknown, bioaccumulative (log Kow=5.61 (Agrichemical Abstracts, 2004)), though water-insolubule and no acute toxicity is reported within the saturated aqueous solution.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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