GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Disodium chromate decahydrate
CAS：13517-17-4
Result：
| ID: | 1168 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Not classified | - | - | - | - | Since it is a nonflammable anhydride combined with crystal water (ICSC (J), 2001), it was considered to be nonflammable and classified asout of Category. |
| 7 | Flammable solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. |
| 9 | Pyrophoric liquids | Not classified | - | - | - | - | Since it is nonflammable (ICSC (J), 2001) anhydride combined with water of crystallization and it is considered nonflammable, it was carried out the outside of Category. |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Not classified | - | - | - | - | It is what the nonflammable (ICSC (J) 2001) anhydride was combined with crystal water, and was considered nonflammable. Therefore, it was carried out the outside of category. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified | - | - | - | - | Stable to water (the water solubility is obtained) |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 14 | Oxidizing solids | Classification not possible | - | - | - | - | ICSC (J) (2001) and HSDB (2005) describe that the anhydride is a "strong oxidizer," this product is also considered to have a strong oxidativity. But we cannot classify it because of insufficient data. |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Inorganic compound |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 3 |
|
Danger | H301: Toxic if swallowed |
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ... |
The LD50 values for sodium chromate anhydride (CAS: 7775-11-3) are 87mg/kg in male and 40mg/kg in female (both EU-RAR (2005)). Because the molecular weight of the decahydrate (approx. 342) is about twice as much as that of the anhydride (approx. 162), the LD50 values were converted to approx. 175mg/kg for male and approx. 80mg/kg for female, and the substance was classified as Category 3. |
| 1 | Acute toxicity （Dermal） | Category 5 | - | Warning | H313: May be harmful in contact with skin | P312: Call a POISON CENTER or doctor/physician if you feel unwell. | It is rabbit LD50 = 1330mg/kg (EU-RAR (2005)) to a sodium chromate anhydrides (CAS:7775-11-3). In 10 hydrate, a molecular weights (about 342) was about twice the anhydride (about 162). And it was set as Category 5 based on concersion rabbit LD50 = about 2800mg/kg. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | It is a liquid in the definition of GHS. In addition, although this product is an existing deliquescent yellow crystals, the melting points is belw 19.9degC (it can be dissolved in water of crystallization). |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Category 2 |
|
Danger | H330: Fatal if inhaled |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P284: Wear respiratory protection. P310: Immediately call a POISON CENTER or doctor/physician. P320: Specific treatment is urgent （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
Rat LC50 = 0.104mg/L/4h to the sodium chromate anhydrides (CAS:7775-11-3) carried out in the state of mist (EU-RAR (2005)). Since a molecular weights of 10 hydrate (about 342) was as about twice as the anhydride (about 162). So it was converted to LC50 = about 0.2mg/L/4h, and it was set as Category 2. |
| 2 | Skin corrosion/irritation | Category 1A-1C |
|
Danger | H314: Causes severe skin burns and eye damage |
P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ... |
In anhydrides of this product (in Sodium chromate (CAS:7775-11-3), there is description that the deep ulcers which shows corrosive and severe irritation to human skin is started (ICSC(2005);SITTIG (4th, 2002)). Furthermore, in the European risk phrases, it was classified with caustic (C;R34) (EU-Annex I (Access on June 2006)), it was set as Category 1A-1C. In addition, further categorizing from this data is difficult. |
| 3 | Serious eye damage/eye irritation | Category 1 |
|
Danger | H318: Causes serious eye damage |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. |
Due to the descriptions that anhydrides of this product (Sodium chromate (CAS:7775-11-3)) shows causticity to the human eye, and it produces serious depths burn and the visual impairment (ICSC(2005);SITTIG (4th, 2002)), it was classified into Category 1. |
| 4 | Respiratory sensitization | Category 1 |
|
Danger | H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled |
P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P285: In case of inadequate ventilation wear respiratory protection. P501: Dispose of contents/container to ... |
About the anhydride of this substance (Sodium chromate (CAS: 7775-11-3)), in addition to repetition or long-term inhalation exposure to human may cause asthma (ICSC(2005)), it is classified into "R42 (inhalation may cause sensitization)" according to the EU risk phrases. Moreover, chromium and chromium compound were classified into "the 2nd group (material considered that there is probably sensitizing to human)" in Japan Association of Industrial Health, and chromium was classified into the material with respiratory sensitization in Japanese Society of Occupational Allergy Special Committee, this product thought that it had respiratory sensitization and was set to Category 1. |
| 4 | Skin sensitization | Category 1 |
|
Warning | H317: May cause an allergic skin reaction |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ... |
About the anhydride of this substance (Sodium chromate (CAS: 7775-11-3)), in addition to there is a description of showing sensitivity to a human skin (ICSC(2005), and SITTIG(4th, 2002)), it is classified into "R42 (inhalation may cause sensitization)" according to the EU risk phrases. Moreover, since hexavalent chromium compound was classified into "Sh (risk of skin sensitization)"in DFG, chromium and chromium compound were classified into "the 1st group (material which has sensitizing clearly to human)" in Japan industrials society, this product was considered to have skin sensitization, and was set to Category 1. |
| 5 | Germ cell mutagenicity | Category 2 |
|
Warning | H341: Suspected of causing genetic defects |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Although it is only a positive in an in vitro mutagenicity test (Ames, chromosome aberration) as data of the this product (a sodium chromate anhydrides (CAS:7775-11-3) is included) (IARC 49, 1990), about the flood solubility hexavalent chromium compound, there is the mutagenicity knowledge in in vivo was indicated (NTP RoC (11th, 2005), IARC49 (1990), EU-RAR (2005)). So and it is classified into Category 2. Refer to potassium dichromate (ID 262, Chemical Abstracts Service:7778-50-9). |
| 6 | Carcinogenicity | Category 1A |
|
Danger | H350: May cause cancer |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
As hexavalent chromium compounds, since it was was classified K (Chromium hexavalent (VI) compounds) in NTP (2005), group 1 (Chromium(VI)) in IARC (1990), and A (as Chromium(VI), Inhalation route) in EPA (1986), respectively, it was classified into Category 1A. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | Since there is no detailed data and also the data is insufficient for this product, it cannot classify. In addition, refer to potassium dichromate (ID 262, CAS: 7778-50-9) about the reproductive toxicity of hexavalent chromium compounds. |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (respiratory system, kidney, liver) |
|
Danger | H370: Causes damage to organs (respiratory system, kidney, liver) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
In the inhalation test (guess at mist) to the rat written in the document of Priority 1, the necrosis of pulmonary edemas, inflammation, and a bronchial epithelium are observed at 0.028mg/L /24h of sodium chromate anhydrides (CAS:7775-11-3) (EU-RAR (2005)). This dose is equivalent to 0.17 mg/L /4h, and when converting into the amount of 10 hydrate (about 0.34 mg/L /4h), it is included in the guidance value of Category 1. Moreover, since there are descriptions that a soluble hexavalent chromium compound affects liver, the kidney, and respiratory organs in ACGIH-TLV (2005). Furthermore, in the inside of the document in Priority 2, "caustic is in a human airway, the caustic by oral ingestion are showed, kidney and liver are affected, and a tissue is injured" (ICSC (2005)), it was considered as Category 1 (the respiratory system, kidney, liver). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (respiratory system, kidney, liver) |
|
Danger | H372: Cause damage to organs through prolonged or repeated exposure (respiratory system, kidney, liver) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Because of the document of Priority 1 that effects on liver, kidney and respiratory tracts occured by water soluble hexavalent chromium compounds (ACGIH-TLV (2005)), and of the description "human respiratory tracts are affected, nasal septal perforations are occured, and kidneys are damaged" in the document of Priority 2 (ICSC (2005), SITTIG (4th, 2002)), it was classified into Category 1 (respiratory system, kidney, liver). |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | No data available |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | No data available. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |