GHS Classification Result

Chemical Name：Quinoline
CAS：91-22-5

Result：
ID: 1158
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - There was information with 59 degC (NFPA, 13th, 2002), 99 degC (Closed Cup) (HSDB, 2003), and 105 degC (ICSC (J), 1993) for flash point (ascending order). If it is 59 degC, it is Category 3; however, according to UNRTDG No. (2656), it is classified as 6.1 and III. Since 3 was not assigned, 99 degC (Closed Cup) (HSDB, 2003) was adopted, and it was considered as out of Category.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - UNRTDG is classified into 6.1 and III according to the U.N. number (2656) peculiar to a substance. Since 4.2 was not attached, it carried out the outside of Category.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing no oxygen, fluorine and chlorine.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - UNRTDG is classified into 6.1 and III according to the UNRTDG No. (2656). Although 8 is not attached, since the data which negates corrosion behavior is not found, it cannot be classified.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Of the LD50 values in rats of 331mg/kg and 460mg/kg (PATTY (5th, 2001), RTECS (2004), HSDB(2003) and IUCLID (2000)), we adopted the lower value to classify the substance as Category 4.
1 Acute toxicity （Dermal） Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was set as Category 3 based on rabbit LD50 = 590mg/kg (converted from 0.54ml/kg) (PATTY (5th, 2001), RTECS (2004), IUCLID (2000)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		It was set as category 2 from the statement that there is irritation of a degree (Moderate) in the middle to skin of rabbits (PATTY (5th, 2001), RTECS (2004)) and the description that human skin are stimulated (ICSC (J) (1993), HSDB (2003)).
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Due to the descriptions that it irritates to the eye of rabbit moderately to severely (PATTY (5th, 2001), IUCLID (2000)), and that it irritates to the human eye (HSDB (2003), ICSC (J), (1993), SITTIG (4th, 2002)), it was classified into Category 2A.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Positive finding is seen in the in vivo small core test using mouse bone marrow cells, in the gene mutation test using mice liver, and the chromosome aberration test using rat hepatic cells (all are IRIS(s) (2001)). So it is classified into Category 2 according to classification guidelines flow.
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since it was categoried into B-2 according to the guideline in 1986 in EPA (IRIS (2001)), it was classified into Category 2.
7 Reproductive toxicity Classification not possible - - - - No data available
8 Specific target organ toxicity - Single exposure Category 2 (respiratory system) Warning H371: May cause damage to organs (respiratory system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since there was description that in Priority 2, a cough, stuffiness, and breathlessness were produced by human exposure of this product and pulmonary edemas and the dyspnea by respiratory muscle paralysis are caused (HSDB (2003), ICSC (J), (1993), SITTIG (4th, 2002)) in high exposure, it was considered as Category 2 (respiratory systems).
9 Specific target organ toxicity - Repeated exposure Category 2 (liver, eye (retina)) Warning H373: May cause damage to organs through prolonged or repeated exposure (liver, eye (retina)) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Because of the reports in Priority 1 and 2 that the effects on rats liver (vascular neoplasm of liver, an increase in liver weight, and bile duct proliferation) at doses classified as Category 2 for guidance values (PATTY (5th, 2001), IUCLID (2000)), and of the description in Priority 2 of the effects on human livers and eyes (retinae) (ICSC(J) (1993), HSDB (2003), SITTIG (4th, 2002)), it was classified into Category 2 (liver, eye (retina)).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 3 from 48-hour EC50=25mg/L of Crustacea (Daphnia magna) (MOE eco-toxicity tests of chemicals, 1995).
11 Hazardous to the aquatic environment （Long-term） Category 3 - - H412: Harmful to aquatic life with long lasting effects P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 3, since acute toxicity was Category 3 and not rapidly degrading (BOD: 0.2% (existing chemical safety inspections data)), though less bio-accumulative (BCF=3.8 (existing chemical safety inspections data)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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