GHS Classification Result

Chemical Name:cadmium di(acetate)
CAS:543-90-8

Result:
ID: 1154
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Non-combustible (ICSC (J) (2001))
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Non-combustible (ICSC (J), 2001)
11 Self-heating substances and mixtures Not classified - - - - Not combustible (ICSC(J) (2001))
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Stable to water (Freely soluble in water)
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - No data available
15 Organic peroxides Not applicable - - - - Inorganic compound
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
SPECIES: Rat ENDPOINT: LD50 VALUE: 333mg/kg REFERENCE SOURCE: RTECS(2004)
1 Acute toxicity (Dermal) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Classification not possible - - - - No data available
3 Serious eye damage/eye irritation Category 2A-2B Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
Although irritation is indicated in the description to the humans in HSDB (2003), since there is no test data and subdivision cannot be made, it was classified into Category 2A-2B. [Indication] 2A is recommended based on the safety, when the Category needs to subdivide.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Although the data of in vivo was not found about the this product, there is positive example by in vitro with two indices (the gene mutation test and chromosome aberration test using a mammalian cells) (RTECS (2004), HSDB (2003)). And in addition the inorganic cadmium compound being classified into 3A according to a germ cell mutagenicity category in MAK/BAT (2004) so the influence on the somatic cell in in vivo was guessed at least. And it is classified into Category 2.
6 Carcinogenicity Category 1A-1B Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
The classification (Group 1,Known to be human carcinogens, 1, respectively ) as cadmium compounds in IARC53 (1993), NTP RoC (11th, 2005), and industrial hygene academic society advice (2004) corresponds to Category 1A, and the classification as cadmium compounds in IRIS (1992) and ACGIH-TLV (2004) corresponds to Category 1B. Since the newness etc. of sources of the both Category were almost equivalent. So it was classified into Category 1A-1B. [Indication] 1A is recommended based on the safety, when the Category needs to subdivide.
7 Reproductive toxicity Category 1B Danger H360: May damage fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
In California Proposition 65 (California EPA/OEHHA, 2005), it is registered as cadmium having reproductive toxicity in sire. It was set as Category 1B.
8 Specific target organ toxicity - Single exposure Category 2 (respiratory system, kidney, liver) Warning H371: May cause damage to organs (respiratory system, kidney, liver) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
It was considered as Category 2 (a respiratory systems, kidney, liver) based on the description in SITTIG (4th, 2002), HSFS (2001), and HSDB (2003) in Priority 2 source in humans (pulmonary edemas, difficulty breathings, respiratory irritant by inhalation exposures), and description in HSDB (2003) (obstacle of the kidney and liver by oral exposure)
9 Specific target organ toxicity - Repeated exposure Category 1 (kidney), Category 2 (liver, lung) Danger
Warning
H372: Cause damage to organs through prolonged or repeated exposure (kidney)
H373: May cause damage to organs through prolonged or repeated exposure (liver, lung)
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Since there is a description of an effect on kidneys by repeated exposure of cadmium compounds (ACGIH-TLV (2004) indicated by Priority 1) and there are also descriptions of the renal effect (SITTIG (4th, 2002), HSFS (2001), and ICSC(J) (2001) indicated by Priority 2), it was classified into Category 1 (kidney). Moreover, based on descriptions of effects on liver and lungs (SITTIG (4th, 2002), HSFS (2001), and ICSC(J) (2001), which are indicated by Priority 2), it was classified into Category 2 (liver, lung).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 96-hour LC50=6.2microg/L of fishes (Rainbow trout), and others (AQUIRE, 2003).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 1, since acute toxicity was Category 1, and it is a metallic compound, behavior in water and bioaccumulative potential are unknown.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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