GHS Classification Result

Chemical Name:endothal
CAS:145-73-3

Result:
ID: 1147
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Non-combustible (PM, 13th, 2003; HSDB, 2002)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Non-combustible (PM, 13th, 2003; HSDB, 2002)
11 Self-heating substances and mixtures Not classified - - - - Non-combustible (PM, 13th, 2003; HSDB, 2002)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) is not included (in the case of free objects, instead of 2 sodium salt, etc.).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing oxygen bonded to only carbon and hydrogen (not disodium salt but free body))
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available. Non-corrosive to metals (HSDB, 2002)

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
Because the oral LD50 in rats was 248mg/kg (Agricultural Chemical Registration Data (1994)), the substance was classified as Category 3. [Note] All the test data regarding health hazards were obtained from tests using the disodium salt preparation of this substance. For the GHS classification, we classified the substance as a disodium salt preparation.
1 Acute toxicity (Dermal) Classification not possible - - - - Rat dermal LD50 was >2000mg/kg (Agricultural Chemical Registration Data (1994)). But data are insufficient for classification, and it cannot be classified.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
Since it was rat inhalation LC50 (mist, 4 hours) = 1.85mg/L (Agricultural Chemical Registration Data (1994)), it was set as Category 4.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P362: Take off contaminated clothing and wash before reuse.
Since severe irritation was indicated to skin of rabbits as a result of the skin irritation study using a rabbit (Agricultural Chemical Registration Data (1994)), it was set as Category 2.
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
In the irritation study using rabit (correspond to GLP), the results of Draize scores after 24, 48, 72 hours of test articles dripping study are equivalent to Category 2A, and also all irritative changes disappeared until 14 days (Agricultural Chemical Registration Data) (1992)).Therefore, it was classified into Category 2A.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Not classified - - - - In the skin sensitivity test (the Maximization method, the Buehler method (all are GLP correspondences)) using a guinea pig, since the negative result was shown (all are Agricultural Chemical Registration Data (1994)), it carried out the outside of Category.
5 Germ cell mutagenicity Classification not possible - - - - There is only the negative data in the in vitro reverse mutation test using salmonella and E..coli (Agricultural Chemical Registration Data (1994)), and no data of in vivo mutagenicity test. So it cannot be classified because of insufficient data.
6 Carcinogenicity Not classified - - - - In the carcinogenicity tests using rat and mouse, since generating of treatment-related increased tumor by this product was not observed (Agricultural Chemical Registration Data (1994)), it was outer the Category.
7 Reproductive toxicity Classification not possible - - - - In the teratogenicity study using a rat, although effect was not admitted (Agricultural Chemical Registration Data (1994)), since the assessments to reproductive potential is not made, it cannot be classified due to insufficient data.
8 Specific target organ toxicity - Single exposure Category 1 (nervous system) Danger H370: Causes damage to organs (nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
Since in the acute toxicity tests where the amount which is equivalent to Category 1 in a guidance value is orally administered to the rat and the mouse, the symptoms such as lethargy, decreased activity, abdominal position, muscle fasciculation, and in pharmacological tests in the mouse, decrease in locomotor activity trend were observed (Agricultural Chemical Registration Data (1994)), it was considered as Category 1 (nerve systems).
9 Specific target organ toxicity - Repeated exposure Category 2 (liver, stomach, testis) Warning H373: May cause damage to organs through prolonged or repeated exposure (liver, stomach, testis) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Because of observed changes in the tissues of liver, stomach, and testes by repeated administration to dogs, and of observed hyperkeratotic thickening of the stratum spinosum of gastric by repeated administration to rats (both in Agricultural Chemical Registration Data (1994)), and of that these doses were equivalent to a guidance value in Category 2, it classified into Category 2 (liver, stomach, testis).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Not classified - - - - It carried out the outside of Category from 48-hour EC50>100 mg/L of Crustacea (Daphnia magna) (Agricultural Chemical Registration Data, 2004).
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Since not water-insoluble (water solubility=100000mg/L(PHYSPROP Database, 2005)) and acute toxicity is low.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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