Chemical Name:Emamectin benzoate
CAS:155569-91-8
ID: | 1141 |
Classifier: | Inter-ministerial Committee on GHS |
Year Classified: | FY2006 |
Reference Manual: | GHS Classification Manual (10 Feb, 2006) |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Explosives | Not classified | - | - | - | - | Not classified because of the oxygen balance calculated at -221.2, lower than -200 of the criteria, though containing N-O bonds as chemical groups associated with explosive properties present. |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | - | Solid (GHS definition) |
3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (GHS definition) |
5 | Gases under pressure | Not applicable | - | - | - | - | Solid (GHS definition) |
6 | Flammable liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
7 | Flammable solids | Classification not possible | - | - | - | - | No data available |
8 | Self-reactive substances and mixtures | Classification not possible | - | - | - | - | Classification not possible due to lack of data, though the substance contains unsaturated C-C bonds as chemical groups with explosive or self-reactive properties present |
9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
10 | Pyrophoric solids | Classification not possible | - | - | - | - | No data available |
11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | No data available |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
14 | Oxidizing solids | Not applicable | - | - | - | - | Organic compounds containing oxygen (but not chlorine and fluorine) and the oxygen is chemically bonded only to carbon and hydrogen (but not to other elements). |
15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no -0-0- structure |
16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to solid substances are not available. |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
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1 | Acute toxicity (Oral) | Category 3 | Danger | H301: Toxic if swallowed |
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment (see ... on this label). P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ... |
Of the rat LD50 values obtained from the 2 oral toxicity tests, based on the lower value: LD50 = 63mg/kg (Agricultural Chemical Registration Data), we classified the substance as Category 3. | |
1 | Acute toxicity (Dermal) | Category 4 | Warning | H312: Harmful in contact with skin |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P280: Wear protective gloves/protective clothing/eye protection/face protection. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P322: Specific treatment (see ... on this label). P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ... |
It was set as Category 4 based on rat LD50 = 2000mg/kg of the dermal administration test (Agricultural Chemical Registration Data). | |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | - | Solid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible | - | - | - | - | No data available |
1 | Acute toxicity (Inhalation: Dusts and mists) | Category 4 | Warning | H332: Harmful if inhaled |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. |
It was set as category 4 based on rat LC50 = 1.93mg/L (Agricultural Chemical Registration Data) of an inhalation exposure test. | |
2 | Skin corrosion/irritation | Not classified | - | - | - | - | In the primary skin irritation test using a rabbit, it carried out the outside of Category based on the statement that an irritant effect was not admitted (Agricultural Chemical Registration Data). |
3 | Serious eye damage/eye irritation | Category 2A | Warning | H319: Causes serious eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. |
There is the description that in the eye primary irritation study using rabbit, corneal opacity, iris congestion, and redness, dropsy and the discharges of the conjunctiva were observed. And the score was 21.75, but it disappeared 13 days after (Agricultural Chemical Registration Data). Therefore, it was classified into Category 2A. | |
4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
4 | Skin sensitization | Not classified | - | - | - | - | Based on the statement (Agricultural Chemical Registration Data) that skin sensitization was not accepted in the skin sensitization study using a guinea pig, it carried out the outside of Category. |
5 | Germ cell mutagenicity | Not classified | - | - | - | - | There is no data of human administration cost epidemiology, an administration cost mutagenicity test, and productive cell in vivo mutagenicity test. And the statement (Agricultural Chemical Registration Data) with negativity by the somatic cell in vivo mutagenicity test (in vivo chromosomal aberration test using mouse bone marrow cells). So it carried out the outside of Category. |
6 | Carcinogenicity | Not classified | - | - | - | - | Since in carcinogenicity test in rat and mouse treatment-related increased tumor was not observed (Agricultural Chemical Registration Data), it was out of the Category. |
7 | Reproductive toxicity | Category 2 | Warning | H361: Suspected of damaging fertility or the unborn child |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
In the two-generation reproduction examination and teratogenicity test using a rat, by medication of the dosage as which general toxicity is regarded in parent animals, It was referred to as Category 2 based on the statement that decline in the pregnancy rate and a fertility of parent animals was seen, and the tremore, hindlimb disorder, and the inhibition of increase weight in a child animals, and the inhibition of increase weight, and skeletal deformity were seen in fetus (Agricultural Chemical Registration Data). | |
8 | Specific target organ toxicity - Single exposure | Category 1 (systemic toxicity, nervous system) | Danger | H370: Causes damage to organs (systemic toxicity, nervous system) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment (see ... on this label). P405: Store locked up. P501: Dispose of contents/container to ... |
As effects on laboratory animals, in a rat, at the dose within the range of guidance value in Category 1 (32-91.4mg/kg), the symptoms such as tremor, the decrease in locomotor activity, ptosis, bradypnea, lateral positions, contamination of hair with urine, and the bloody secretion of a nose and eyes were observed, and in a mouse acute oral administration test, at the dose within the range of guidance value in Category 1 (70-192mg/kg), the symptoms, such as tremor, ataxia, blepharoptosia, hypokinesis, bradypnea, and a lateral recumbent position, were observed (Agricultural Chemical Registration Data ). It was considered as Category 1 (systemic, nervous systems) based on the above. | |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (nervous system) | Danger | H372: Cause damage to organs through prolonged or repeated exposure (nervous system) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
It was classified into Category 1 (nerve systems) based on the description that in the subacute toxicity study using a rat with the dose of 0.8-2.5 mg/kg weight(within the range of guidance value in Category 1), the decreased weight gain, tremor, the vacuolation of a neuron, the degeneration of a spinal cord and the sciatic nerve, atrophy of skeletal muscle and weakening of grip strength were observed (Agricultural Chemical Registration Data). | |
10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 1 | Warning | H400: Very toxic to aquatic life |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
It was classified into Category 1 from 48-hour EC50=1microg/L of Crustacea (Daphnia magna) (Agricultural Chemical Registration Data, 2003). | |
11 | Hazardous to the aquatic environment (Long-term) | Category 1 | Warning | H410: Very toxic to aquatic life with long lasting effects |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Classified into Category 1, since acute toxicity was Category 1, supposedly bioaccumulative (log Kow=5.77 (Agricultural Chemical Registration Data, 2004)), and rapid degradability is unknown. |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website (in Japanese Only) |
Model SDS by MHLW |
MHLW Website (in Japanese Only) |