GHS Classification Result

Chemical Name：fosthiazate
CAS：98886-44-3

Result：
ID: 1139
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Classification not possible - - - - No data available
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Classification not possible - - - - Classification not possible due to lack of data, though the substance contains N-O bonds as chemical groups with explosive or self-reactive properties present
9 Pyrophoric liquids Classification not possible - - - - No data available
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Based on the water solubility measurement was performed (Agricultural Chemical Registration Data), it is judged that it is stable in the water.
13 Oxidizing liquids Classification not possible - - - - No data available
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the rat oral LD50: 57mg/kg (Agricultural Chemical Registration Data), the substance was classified as Category 3.
1 Acute toxicity （Dermal） Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was set as Category 3 based on rat dermal LD50 = 861mg/kg (Agricultural Chemical Registration Data).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Category 3 Danger H331: Toxic if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P311: Call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was set as category 3 based on 4-hour exposure LC50 = 0.558mg/L (Agricultural Chemical Registration Data) of rat inhalation (mist).
2 Skin corrosion/irritation Not classified - - - - Based on the statement (Agricultural Chemical Registration Data) by very slight erythema only having been seen in the rabbit, it carried out the outside of Category.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		Although conjunctival vascular hyperaemia, chemosis of conjunctiva, and discharges in eye were observed in the rabbit (Agricultural Chemical Registration Data), it recovered after seven days. Therefore, it was classified into Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Based on the statement (Agricultural Chemical Registration Data) that skin sensitization was seen in the guinea pig, it was referred to as Category 1.
5 Germ cell mutagenicity Not classified - - - - There is no result of human administration cost epidemiology, an administration cost mutagenicity test, and a productive cell in vivo mutagenicity test. And the statement (Agricultural Chemical Registration Data) with negativity by the somatic cell in vivo mutagenicity test (micronucleus test which uses mouse bone marrow). So it carried out the outside of Category.
6 Carcinogenicity Not classified - - - - Based on the description that carcinogenicity was not observed in the mouse and the rat (Agricultural Chemical Registration Data), it was out the Category.
7 Reproductive toxicity Category 1 Danger H360: May damage fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In the two-generation reduction study, the statement that the survival rate of F1 baby and reduction of weight were seen with the dose (30ppm) that toxicity was not observed for parental animals, and in the teratogenicity test of a rabbit, although a fetas did not have teratogenicity, the frequency of appearance of the slight fall of fetus weight and small fetas increased slightly by the dose which does not have toxicity in parental animals (Agricultural Chemical Registration Data). So it was set as Category 1.)
8 Specific target organ toxicity - Single exposure Category 1 (systemic toxicity, nervous system) Danger H370: Causes damage to organs (systemic toxicity, nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was considered as Category 1 (generalized, nervous system) based on the description that lethargy, diminished spontaneous activity, proneness, prone position, kyphosis position, muscle tremor, irregular breathing, piloerection, ataxia, grooming-disappeared, colored eye secretions, colored contamination in nasal meatus part, tabefaction, salivation, breathing rate slowed, limb palsy, contamination within the oral cavity, bleed nose, eye haemorrhage, and dacryorrhea were observed with oral administration, dermal administration, and inhalation in a mouse and a rat at the dose within the range of guidance value in Category 1 (41-128mg/kg, 312-786mg/kg, 0.532-0.9mg/L).
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system, adrenal gland) Danger H372: Cause damage to organs through prolonged or repeated exposure (nervous system, adrenal gland) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		There are the description that in a rat, with the dose (30.9 mg/kg) within the range of guidance value in Category 2, hyper cholinesterase inhibition and a neurological disorders were occured, and the description that in a dog, with the dose (5.4 mg/kg/day) within the range of guidance value in Category 1, pathological change of adrenal glant, inhibition of erythrocyte and brain cholinesterase and decrease of erythrocyte numbers were observed (Agricultural Chemical Registration Data). It was classified into Category 1 (a nervous systems, the adrenal glant) based on these informations.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - It carried out the outside of Category from ErC50>100mg/L of algae (Green algae) (Agricultural Chemical Registration Data, 2004) .
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since not water-insoluble (aqueous solubility = 9850mg/L(PHYSPROP Database, 2005)) and acute toxicity is low.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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