GHS Classification Result

Chemical Name：mecarbam
CAS：2595-54-2

Result：
ID: 1134
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Classification not possible - - - - No data available
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Uses are agricultural chemicals, and even if it contacts the normal temperature air, it does not ignite spontaneously.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Stable to water (the water solubility is obtained)
13 Oxidizing liquids Classification not possible - - - - No data available
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 2 Danger H300: Fatal if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Of the LD50 values 31-33mg/kg in male rats and 23-53mg/kg in female rats in Priority 1 (JMPR524(1980)), we adopted the higher toxicity value (LD50 = 23mg/kg) and classified the substance as Category 2.
1 Acute toxicity （Dermal） Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was set as Category 3 based on rabbit LD50 = 229mg/kg (JMPR524 (1980)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was classified as Category 2 based on LC50 = 0.9mg/L. This value obtained by converting LC50 value (0.7mg/L) (indicated in JMPR524 (1980)) for 4 hours. In addition, since the saturated concentration of this product by calculation is 1713ppm (equivalent: 2.31* 10^7mg/L), it was presumed that the inhalation experiment was conducted in the state of steam.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Classification not possible - - - - No data available
3 Serious eye damage/eye irritation Classification not possible - - - - No data available
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Not classified - - - - Since it was negative in the mouse bone marrow micronucleus tests (JMPR634 (1983)), it carried out the outside of Category according to the guideline.
6 Carcinogenicity Not classified - - - - In Priority 1, since there is a report that the this product does not show carcinogenic to rat (JMPR524 (1980)), it was out of the Category. In addition, there is no carcinogenicity tests data in mouse.
7 Reproductive toxicity Classification not possible - - - - In the information on Priority 1, using rat, although reproductive and developmental toxicity are not acknowledged in the dose (2mg/kg) in which the general toxicity in parental animals do not appear (affected to reproductive potential in 50mg/kg (near LD50 value)), performing not a suitable dose setup. So it is thought that data is insufficient for a classification and it cannot classify .
8 Specific target organ toxicity - Single exposure Category 2 (nervous system) Warning H371: May cause damage to organs (nervous system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since there was description which affects the human nervous systems (late neurotoxicity, polyneuropathy) (HSDB (2003)) in Priority 2, it was considered as Category 2 (nervous systems).
9 Specific target organ toxicity - Repeated exposure Not classified - - - - Since in the animal experiments (a maximum of two years), the tremor (feeding administration) or irritation of the respiratory tracts (inhalation administration) was observed only with high doses, and effect was not observed within the range of guidance value, it was considered as the outside of Category.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - Insufficient data available.
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - Classification not possible due to lack of data


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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